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- Publisher
- Karger
- Copyright
- © 1958 S. Karger AG, Basel
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- DOI
- 10.1159/000205455
- Publisher site
- See Article on Publisher Site
Abstract
Cross, L . : A cta h a cm at 19: 353—361 (1958) From the Cancer Research Unit, Veterans Administration Hospital, Bronx, New York A tte m p t to R e c o v e r F i l t e r a b l e A g e n t f r o m X-Ray- I n d u c e d L e u k e m ia * By L u d w i k G ross There are many difficulties in the proper interpretation of results of experiments dealing with cell-free transmission of mouse leukemia. One of the difficulties is the fact that leukemia can be induced in mice not only by inoculation of filtrates containing a transmissible oncogenic agent, presumably a virus (3-8, 10, 11), but also by other, apparently not specific means, such as appli cation of certain carcinogenic chemicals, injection of estrogenic hormones, or by total body X-ray irradiation (18, 1, 19, 13, 16). Since, theoretically, at least, it may be possible to assume that carcinogenic chemicals, hormones, or ionizing radiation may induce leukemia in mice indirectly only, by activating latent viruses carried in an inactive form by apparently healthy hosts
Journal
Acta Haematologica – Karger
Published: Jan 1, 2009