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Myelodysplastic Syndrome Presenting with Generalized Cutaneous Granulocytic Sarcomas

Myelodysplastic Syndrome Presenting with Generalized Cutaneous Granulocytic Sarcomas A patient with myelodysplastic syndrome (refractory anemia with excess of blasts in transformation, RAEB-T) presented with generalized granulocytic sarcomas involving the skin. The diagnosis was confirmed by skin and bone marrow biopsies. Partial myeloperoxidase deficiency was noted in the circulating polymorphonuclear leukocytes and the more differentiated tumor cells in the granulocytic sarcoma. This observation suggests that such leukocytes may be derived from the abnormal ‘leukemic’ clone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Myelodysplastic Syndrome Presenting with Generalized Cutaneous Granulocytic Sarcomas

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Publisher
Karger
Copyright
© 1990 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000205175
Publisher site
See Article on Publisher Site

Abstract

A patient with myelodysplastic syndrome (refractory anemia with excess of blasts in transformation, RAEB-T) presented with generalized granulocytic sarcomas involving the skin. The diagnosis was confirmed by skin and bone marrow biopsies. Partial myeloperoxidase deficiency was noted in the circulating polymorphonuclear leukocytes and the more differentiated tumor cells in the granulocytic sarcoma. This observation suggests that such leukocytes may be derived from the abnormal ‘leukemic’ clone.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1990

Keywords: Myeloperoxidase deficiency; Granulocytic sarcoma; Myelodysplastic syndrome

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