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A Continuous Spectrum of Hypercoagulability Exists in Acute Nonlymphoblastic Leukemia

A Continuous Spectrum of Hypercoagulability Exists in Acute Nonlymphoblastic Leukemia A consumption coagulopathy syndrome has frequently been reported in association with some cases of acute nonlymphoblastic leukemia (ANLL) and mainly in acute promyelocytic leukemia (M3). Eighteen cases of ANLL have been studied on admission, before chemotherapy was started. Levels of antithrombin III (AT-III), protein C (PC), protein S (PS), thrombin-antithrombin complex (T-AT-III), tissue plasminogen activator, plasminogen (Pg), alpha-2-antiplasmin (alpha-2-AP), D-dimer (DD) and fibrinogen (Fg) were determined. The results showed normal levels of AT-III and PS, decreased levels of PC, alpha-2-AP, Pg and Fg in some cases, and an elevation of DD and T-AT III complex in almost all patients. There was a continuous evolution of data from Ml cases in which only slight alterations were seen up to M3 cases where all those pathologic data were observed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

A Continuous Spectrum of Hypercoagulability Exists in Acute Nonlymphoblastic Leukemia

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Publisher
Karger
Copyright
© 1992 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000204661
Publisher site
See Article on Publisher Site

Abstract

A consumption coagulopathy syndrome has frequently been reported in association with some cases of acute nonlymphoblastic leukemia (ANLL) and mainly in acute promyelocytic leukemia (M3). Eighteen cases of ANLL have been studied on admission, before chemotherapy was started. Levels of antithrombin III (AT-III), protein C (PC), protein S (PS), thrombin-antithrombin complex (T-AT-III), tissue plasminogen activator, plasminogen (Pg), alpha-2-antiplasmin (alpha-2-AP), D-dimer (DD) and fibrinogen (Fg) were determined. The results showed normal levels of AT-III and PS, decreased levels of PC, alpha-2-AP, Pg and Fg in some cases, and an elevation of DD and T-AT III complex in almost all patients. There was a continuous evolution of data from Ml cases in which only slight alterations were seen up to M3 cases where all those pathologic data were observed.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1992

Keywords: Hypercoagulability; t-PA; Acute nonlymphoblastic leukemia; Disseminated intravascular coagulation; Fibrinolysis

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