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An Abnormal Substance Present in the Erythroblasts of Thalassaemia Major. Cytochemical Investigations

An Abnormal Substance Present in the Erythroblasts of Thalassaemia Major. Cytochemical... Astaldi, G., E. G. Rondanelli, E. Bernardelli, E. Strosselli: Acta h a em at. 12, 145— 153, 1954. D epartm ent of Internal Medicine University of Pavia, Italy (Director: Prof. P. Introzzi) An A b n o rm a l S u b stan ce P r e s e n t in th e E ry th ro b la s ts o f T h a la ssa e m ia M ajor C ytochem ical In v e stig atio n s By G. ASTALDI, E. G. RONDANELLI, E. BERNARDELLI, E. STROSSELLI (W ith plates I and II) During investigations on the Hotchkiss reaction of bone marrow cells we examined marrow smears from children with Thalassaemia major. We were surprised to find that in this disease a certain number of erythroblasts invariably gave a positive reaction (3) although ery­ throblasts are generally reported to react negatively to the periodic acid-Schiff (P .A . S.) test. In fact, even though the literature on this subject is plentiful (2, 14, 17, 20, 21, 42, 47, 5 1), no one has con­ firmed Wachstein’s (49) observation that under physiologic conditions there is a slight positive P. A. S. reaction http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

An Abnormal Substance Present in the Erythroblasts of Thalassaemia Major. Cytochemical Investigations

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Publisher
Karger
Copyright
© 1954 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000204611
Publisher site
See Article on Publisher Site

Abstract

Astaldi, G., E. G. Rondanelli, E. Bernardelli, E. Strosselli: Acta h a em at. 12, 145— 153, 1954. D epartm ent of Internal Medicine University of Pavia, Italy (Director: Prof. P. Introzzi) An A b n o rm a l S u b stan ce P r e s e n t in th e E ry th ro b la s ts o f T h a la ssa e m ia M ajor C ytochem ical In v e stig atio n s By G. ASTALDI, E. G. RONDANELLI, E. BERNARDELLI, E. STROSSELLI (W ith plates I and II) During investigations on the Hotchkiss reaction of bone marrow cells we examined marrow smears from children with Thalassaemia major. We were surprised to find that in this disease a certain number of erythroblasts invariably gave a positive reaction (3) although ery­ throblasts are generally reported to react negatively to the periodic acid-Schiff (P .A . S.) test. In fact, even though the literature on this subject is plentiful (2, 14, 17, 20, 21, 42, 47, 5 1), no one has con­ firmed Wachstein’s (49) observation that under physiologic conditions there is a slight positive P. A. S. reaction

Journal

Acta HaematologicaKarger

Published: Jan 1, 2009

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