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Plasma Exchange as a Necessary Prerequisite for the Induction of Remission by Human Immunoglobulin in Auto-Immune Haemolytic Anaemia

Plasma Exchange as a Necessary Prerequisite for the Induction of Remission by Human... High-dosage intravenous human immunoglobulin G (IV IgG) has been used with varying degrees of success to treat a variety of auto-immune disorders which are frequently characterized by a predominantly pathogenic auto-antibody. The present report, in which consistent control and ultimately complete remission of a resistant auto-immune haemolytic anaemia (AIHA) was achieved by carrying out preliminary plasma exchange as a crucial prelude to the administration of high-dose IV IgG provides not only insight into the immuno-regulatory action of the IgG but also raises the interesting possibility that similar benefit might be obtained by such combined procedures in other resistant auto-immune diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Plasma Exchange as a Necessary Prerequisite for the Induction of Remission by Human Immunoglobulin in Auto-Immune Haemolytic Anaemia

Acta Haematologica , Volume 91 (3): 4 – Jan 1, 1994

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Publisher
Karger
Copyright
© 1994 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000204326
Publisher site
See Article on Publisher Site

Abstract

High-dosage intravenous human immunoglobulin G (IV IgG) has been used with varying degrees of success to treat a variety of auto-immune disorders which are frequently characterized by a predominantly pathogenic auto-antibody. The present report, in which consistent control and ultimately complete remission of a resistant auto-immune haemolytic anaemia (AIHA) was achieved by carrying out preliminary plasma exchange as a crucial prelude to the administration of high-dose IV IgG provides not only insight into the immuno-regulatory action of the IgG but also raises the interesting possibility that similar benefit might be obtained by such combined procedures in other resistant auto-immune diseases.

Journal

Acta HaematologicaKarger

Published: Jan 1, 1994

Keywords: Haemolytic anaemia; Immunoglobulin G; Plasma exchange

There are no references for this article.