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Polycythemia with Features of Cushing’s Syndrome Produced by Luteomas

Polycythemia with Features of Cushing’s Syndrome Produced by Luteomas From the Veterans Administration Hospital, Dallas, Texas; the Biology Division of Oak Ridge National Laboratory, Oak Ridge, Tennessee; and the Department of Experimental Medicine, Southwestern Medical School of the University of Texas, Dallas. P o ly cy th em ia w ith F e a tu re s o f C u sh in g’s S y n d ro m e P ro d u c e d hy L u teom as* By RAYMOND G. G O T TSCH A LK ** and JACOB FU R T H The availability of experimental neoplasms discharging mascu­ linizing or feminizing hormones in large quantities gave an opportunity to study the effects of these hormones on red-cell and plasma volumes and on hemopoiesis. The estrogen-secreting (feminizing) human tumors arc cither of the granulosa or of the theca-cell type. The masculinizing human tumors are known as luteomas, adrenal rest tumors, or arrhenoblasto- mas. In the work here described ovarian neoplasms of these two types induced in mice have been studied in parallel experiments. Transplanted granulosa-cell tumors in mice produce a severe con­ gestion of some abdominal viscera (1) and hypervolemia (2, 3 ). Mice bearing such tumors show signs of estrogen http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Polycythemia with Features of Cushing’s Syndrome Produced by Luteomas

Acta Haematologica , Volume 5 (2): 24 – Jan 1, 2009

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Publisher
Karger
Copyright
© 1951 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000203816
Publisher site
See Article on Publisher Site

Abstract

From the Veterans Administration Hospital, Dallas, Texas; the Biology Division of Oak Ridge National Laboratory, Oak Ridge, Tennessee; and the Department of Experimental Medicine, Southwestern Medical School of the University of Texas, Dallas. P o ly cy th em ia w ith F e a tu re s o f C u sh in g’s S y n d ro m e P ro d u c e d hy L u teom as* By RAYMOND G. G O T TSCH A LK ** and JACOB FU R T H The availability of experimental neoplasms discharging mascu­ linizing or feminizing hormones in large quantities gave an opportunity to study the effects of these hormones on red-cell and plasma volumes and on hemopoiesis. The estrogen-secreting (feminizing) human tumors arc cither of the granulosa or of the theca-cell type. The masculinizing human tumors are known as luteomas, adrenal rest tumors, or arrhenoblasto- mas. In the work here described ovarian neoplasms of these two types induced in mice have been studied in parallel experiments. Transplanted granulosa-cell tumors in mice produce a severe con­ gestion of some abdominal viscera (1) and hypervolemia (2, 3 ). Mice bearing such tumors show signs of estrogen

Journal

Acta HaematologicaKarger

Published: Jan 1, 2009

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