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From the Veterans Administration Hospital, Dallas, Texas; the Biology Division of Oak Ridge National Laboratory, Oak Ridge, Tennessee; and the Department of Experimental Medicine, Southwestern Medical School of the University of Texas, Dallas. P o ly cy th em ia w ith F e a tu re s o f C u sh in g’s S y n d ro m e P ro d u c e d hy L u teom as* By RAYMOND G. G O T TSCH A LK ** and JACOB FU R T H The availability of experimental neoplasms discharging mascu linizing or feminizing hormones in large quantities gave an opportunity to study the effects of these hormones on red-cell and plasma volumes and on hemopoiesis. The estrogen-secreting (feminizing) human tumors arc cither of the granulosa or of the theca-cell type. The masculinizing human tumors are known as luteomas, adrenal rest tumors, or arrhenoblasto- mas. In the work here described ovarian neoplasms of these two types induced in mice have been studied in parallel experiments. Transplanted granulosa-cell tumors in mice produce a severe con gestion of some abdominal viscera (1) and hypervolemia (2, 3 ). Mice bearing such tumors show signs of estrogen
Acta Haematologica – Karger
Published: Jan 1, 2009
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