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Increased Serum Levels of sFlt-1 and sEng -
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- Publisher
- Karger
- Copyright
- © 2008 S. Karger AG, Basel
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- DOI
- 10.1159/000178143
- Publisher site
- See Article on Publisher Site
Abstract
The anti-angiogenic factors soluble fms-like tyrosine kinase (sFlt)-1 and soluble endoglin (sEng) have been shown to be of importance in angiogenesis by sequestering and inhibiting vascular endothelial growth factor, placenta-like growth factor and transforming growth factor-β<sub>1</sub> signaling. Given the potential role of angiogenesis in the pathophysiology of sickle cell disease (SCD)-related complications, serum levels of sFlt-1 and sEng were determined in SCD patients and controls. Both sFlt-1 (p = 0.002) and sEng (p = 0.004) were elevated in patients during clinically asymptomatic SCD with no further increment during painful crisis. These data suggest that sFlt-1 and sEng may be important in the regulation of angiogenesis in SCD.
Journal
Acta Haematologica – Karger
Published: Jan 1, 2008
Keywords: Vascular endothelial growth factor; Angiogenesis; Endoglin; fms-like tyrosine kinase; Placenta-like growth factor; sEng; sFlt-1; Sickle cell disease