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Expression of CD157 and CD38 Antigens on Human Myeloid Leukaemia Cells: A Similar Pattern of Modulation with Differentiating Inducers

Expression of CD157 and CD38 Antigens on Human Myeloid Leukaemia Cells: A Similar Pattern of... IntroductionHuman CD38 is a 46-kD transmembrane glycoprotein that mediates multifunction activities, including signal transduction and cyclic ADP-ribose synthesis. It has been suggested that CD38 has an adhesion role, demonstrating that this molecule mediates weak cell binding to endothelium, probably through direct interaction with a ligand (CD31) located on the surface of endothelial cells. CD38 is physiologically down-regulated during myeloid cell differentiation, in that a significant proportion of normal precursor bone marrow cells (CD34+) express CD38 antigen, whereas it is only produced in small amount by normal mature polymorphonuclear cells [1]. Induction experiments indicate that all-trans retinoic acid (ATRA) is a potent and highly specific inducer of this antigen in myeloid cells. ATRA is notably able to upregulate CD38 antigen on human marrow CD34+ progenitor cells [2], but also on blast cells from the acute myeloblastic leukaemia (AML) cell line HL-60 [3], as well as on freshly isolated acute promyelocytic and AML cells when exposed to ATRA in vitro [4]and in vivo after oral treatment with ATRA [3].The gene super-family encoding CD38 also encodes several related cyclases. These include a second human gene, CD157 (BST-1), showing remarkable conservation of the exon structure as well as the structure of the encoded http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Expression of CD157 and CD38 Antigens on Human Myeloid Leukaemia Cells: A Similar Pattern of Modulation with Differentiating Inducers

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References (11)

Publisher
Karger
Copyright
© 2001 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000046575
Publisher site
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Abstract

IntroductionHuman CD38 is a 46-kD transmembrane glycoprotein that mediates multifunction activities, including signal transduction and cyclic ADP-ribose synthesis. It has been suggested that CD38 has an adhesion role, demonstrating that this molecule mediates weak cell binding to endothelium, probably through direct interaction with a ligand (CD31) located on the surface of endothelial cells. CD38 is physiologically down-regulated during myeloid cell differentiation, in that a significant proportion of normal precursor bone marrow cells (CD34+) express CD38 antigen, whereas it is only produced in small amount by normal mature polymorphonuclear cells [1]. Induction experiments indicate that all-trans retinoic acid (ATRA) is a potent and highly specific inducer of this antigen in myeloid cells. ATRA is notably able to upregulate CD38 antigen on human marrow CD34+ progenitor cells [2], but also on blast cells from the acute myeloblastic leukaemia (AML) cell line HL-60 [3], as well as on freshly isolated acute promyelocytic and AML cells when exposed to ATRA in vitro [4]and in vivo after oral treatment with ATRA [3].The gene super-family encoding CD38 also encodes several related cyclases. These include a second human gene, CD157 (BST-1), showing remarkable conservation of the exon structure as well as the structure of the encoded

Journal

Acta Haematologica – Karger

Published: Aug 1, 2001

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