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Plasmapheresis for Thrombotic Thrombocytopenic Purpura following Bone Marrow Transplantation

Plasmapheresis for Thrombotic Thrombocytopenic Purpura following Bone Marrow Transplantation Recognition of thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) following bone marrow transplantation (BMT) has increased in recent years. The use of plasma exchange has greatly improved the outlook of de novo TTP. Fewer data are available on its use in post-BMT TTP but small uncontrolled series showed poor results with low response rates. We present here a case of a young patient who developed manifestations of TTP 10 months after BMT with complete recovery following treatment with plasma exchange for 1 month. This case suggests that plasma exchange could be life saving and should be tried in every patient with post-BMT TTP. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Plasmapheresis for Thrombotic Thrombocytopenic Purpura following Bone Marrow Transplantation

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References (13)

Publisher
Karger
Copyright
© 2001 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000046558
Publisher site
See Article on Publisher Site

Abstract

Recognition of thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) following bone marrow transplantation (BMT) has increased in recent years. The use of plasma exchange has greatly improved the outlook of de novo TTP. Fewer data are available on its use in post-BMT TTP but small uncontrolled series showed poor results with low response rates. We present here a case of a young patient who developed manifestations of TTP 10 months after BMT with complete recovery following treatment with plasma exchange for 1 month. This case suggests that plasma exchange could be life saving and should be tried in every patient with post-BMT TTP.

Journal

Acta HaematologicaKarger

Published: Jul 1, 2001

Keywords: Thrombotic thrombocytopenic purpura; Hemolytic uremic syndrome; Bone marrow transplantation; Plasma exchange

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