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E. Haas, S. Oosting, J. Lefrandt, B. Wolffenbuttel, D. Sleijfer, J. Gietema (2010)
The metabolic syndrome in cancer survivors.The Lancet. Oncology, 11 2
N. Skakkebaek, E. Meyts, K. Main (2001)
Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspectsAPMIS, 109
T. Ishikawa, S. Kamidono, M. Fujisawa (2004)
Fertility after high-dose chemotherapy for testicular cancer.Urology, 63 1
P. Willemse, J. Burggraaf, N. Hamdy, N. Weijl, C. Vossen, L. Wulften, A. Tol, F. Rosendaal, S. Osanto (2013)
Prevalence of the metabolic syndrome and cardiovascular disease risk in chemotherapy-treated testicular germ cell tumour survivorsBritish Journal of Cancer, 109
M. Bandak, N. Jørgensen, A. Juul, J. Lauritsen, Maria Kier, M. Mortensen, G. Daugaard (2017)
Preorchiectomy Leydig Cell Dysfunction in Patients With Testicular CancerClinical Genitourinary Cancer, 15
D. Pectasides, M. Pectasides, D. Farmakis, M. Nikolaou, M. Koumpou, V. Kostopoulou, N. Mylonakis (2004)
Testicular function in patients with testicular cancer treated with bleomycin-etoposide-carboplatin (BEC(90)) combination chemotherapy.European urology, 45 2
P. Petersen, N. Skakkebæk, Kirsten Vistisen, Mikael Rørth, A. Giwercman (1999)
Semen quality and reproductive hormones before orchiectomy in men with testicular cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 17 3
P. Wiechno, T. Demkow, K. Kubiak, M. Sadowska, J. Kamińska (2007)
The quality of life and hormonal disturbances in testicular cancer survivors in Cisplatin era.European urology, 52 5
P. Petersen, A. Andersson, M. Ro̸rth, G. Daugaard, N. Skakkebæk (1999)
Undetectable inhibin B serum levels in men after testicular irradiation.The Journal of clinical endocrinology and metabolism, 84 1
J. Andersen, H. Herning, O. Witczak, T. Haugen (2016)
Anti-Müllerian hormone in seminal plasma and serum: association with sperm count and sperm motility.Human reproduction, 31 8
K. Hemminki, K. Hemminki, Xinjun Li (2004)
Familial risk in testicular cancer as a clue to a heritable and environmental aetiologyBritish Journal of Cancer, 90
M. Singhera, R. Huddart (2013)
Comment on ‘Prevalence of the metabolic syndrome and cardiovascular disease risk in chemotherapy-treated testicular germ cell tumour survivors'British Journal of Cancer, 109
S. Grundy, H. Brewer, J. Cleeman, Sidney Smith, C. Lenfant (2004)
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to DefinitionArteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, 24
S. Hansen, J. Berthelsen, H. Maase (1990)
Long-term fertility and Leydig cell function in patients treated for germ cell cancer with cisplatin, vinblastine, and bleomycin versus surveillance.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 8 10
A. Vermeulen, Lieve Verdonck, Jean Kaufman (1999)
A critical evaluation of simple methods for the estimation of free testosterone in serum.The Journal of clinical endocrinology and metabolism, 84 10
K. Alberti, P. Zimmet, J. Shaw (2005)
The metabolic syndrome—a new worldwide definitionThe Lancet, 366
C. Nord, T. Bjøro, Dag Ellingsen, A. Mykletun, O. Dahl, O. Klepp, R. Bremnes, E. Wist, S. Fosså (2003)
Gonadal hormones in long-term survivors 10 years after treatment for unilateral testicular cancer.European urology, 44 3
A. Swerdlow, B. Stavola, M. Swanwick, N. Maconochie (1997)
Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiologyThe Lancet, 350
Waist Circumference and waist-hip ratio report of a WHO expert consultation
M. Sprauten, M. Brydøy, H. Haugnes, M. Cvancarova, T. Bjøro, J. Bjerner, S. Fosså, J. Oldenburg (2014)
Longitudinal serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels in a population-based sample of long-term testicular cancer survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32 6
S. Grundy, H. Brewer, J. Cleeman, Sidney Smith, C. Lenfant, R. Bonow, R. Eckel, D. Einhorn, S. Haffner, R. Holman, E. Horton, R. Krauss, Daniel Levy, X. Pi-Sunyer, D. Porte, G. Reaven, F. Sacks, N. Stone, P. Wilson (2004)
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to DefinitionCirculation: Journal of the American Heart Association, 109
A. Verdecchia, S. Francisci, H. Brenner, G. Gatta, A. Micheli, L. Mangone, I. Kunkler (2007)
Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data.The Lancet. Oncology, 8 9
Skakkebaek (2001)
Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspectsHum Reprod, 16
R. Rey, C. Lukas-Croisier, C. Lasala, P. Bedecarrás (2003)
AMH/MIS: what we know already about the gene, the protein and its regulationMolecular and Cellular Endocrinology, 211
S. Rasmussen, C. Torp‐Pedersen, K. Borch-Johnsen, H. Ibsen (1998)
Normal values for ambulatory blood pressure and differences between casual blood pressure and ambulatory blood pressure: results from a Danish population surveyJournal of Hypertension, 16
H. Haugnes, N. Aass, S. Fosså, Olav Dahl, O. Klepp, E. Wist, J. Svartberg, T. Wilsgaard, R. Bremnes (2006)
Components of the metabolic syndrome in long-term survivors of testicular cancer.Annals of oncology : official journal of the European Society for Medical Oncology, 18 2
D. Haas, R. Altena, H. Boezen, N. Zwart, A. Smit, S. Bakker, A. Roon, A. Postma, B. Wolffenbuttel, H. Hoekstra, F. Leeuwen, D. Sleijfer, J. Gietema (2013)
Early development of the metabolic syndrome after chemotherapy for testicular cancer.Annals of oncology : official journal of the European Society for Medical Oncology, 24 3
Ahmed Al-Qahtani, S. Muttukrishna, M. Appasamy, Jemma Johns, M. Cranfield, Jenny Visser, A. Themmen, Nigel Groome (2005)
Development of a sensitive enzyme immunoassay for anti‐Müllerian hormone and the evaluation of potential clinical applications in males and femalesClinical Endocrinology, 63
P. Petersen, N. Skakkebaek, M. Ro̸rth, A. Giwercman (1999)
Semen quality and reproductive hormones before and after orchiectomy in men with testicular cancer.The Journal of urology, 161 3
Evaluation Expert Panel on Detection (2001)
Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)JAMA, 285
J. Nuver, A. Smit, B. Wolffenbuttel, W. Sluiter, H. Hoekstra, D. Sleijfer, J. Gietema (2006)
The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23 16
T. Jensen, A. Andersson, N. Hjollund, T. Scheike, H. Kolstad, A. Giwercman, T. Henriksen, E. Ernst, J. Bonde, Jørn Olsen, A. McNeilly, N. Groome, N. Skakkebæk (1997)
Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men.The Journal of clinical endocrinology and metabolism, 82 12
Nuver (2005)
The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancerJ Clin Oncol, 23
(2002)
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.Circulation, 106 25
A. Giwercman, H. Maase, J. Berthelsen, M. Ro̸rth, Aksel Bertelsen, N. Skakkebæk (1991)
Localized irradiation of testes with carcinoma in situ: effects on Leydig cell function and eradication of malignant germ cells in 20 patients.The Journal of clinical endocrinology and metabolism, 73 3
M. Bandak, Niels Jørgensen, Anders Juul, I. Vogelius, J. Lauritsen, M. Kier, M. Mortensen, P. Glovinski, G. Daugaard (2016)
Testosterone deficiency in testicular cancer survivors – a systematic review and meta‐analysisAndrology, 4
Testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to healthy controls. However, because of the fetal etiology of testicular cancer, familial unrelated healthy men might not be an optimal control group. The objective of this study was to clarify if testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to their biological brothers. A cross‐sectional study of testicular cancer survivors (ClinicalTrials.gov number, NCT02240966) was conducted between 2014 and 2016. Of 158 testicular cancer survivors included, 24 had a biological brother who accepted to participate in the study. Serum levels of reproductive hormones and prevalence of metabolic syndrome according to International Diabetes Federation Criteria and National Cholesterol Education Program (Adult Treatment Panel III) criteria comprised the main outcome measures of the study. Median age was similar in testicular cancer survivors and their biological brothers [44 years (IQR 39–50) vs. 46 (40–53) years respectively (p = 0.1)]. In testicular cancer survivors, follow‐up since treatment was 12 years (7–19). Serum levels of luteinizing hormone and follicle‐stimulating hormone were elevated (p ≤ 0.001), while total testosterone, free testosterone, inhibin B and anti‐Müllerian hormone were lower (p ≤ 0.001) in testicular cancer survivors than in their biological brothers. The prevalence of metabolic syndrome was similar and apart from HDL‐cholesterol, which was lower in testicular cancer survivors (p = 0.01); there were no differences in the individual components of the metabolic syndrome between testicular cancer survivors and their brothers. In conclusion, gonadal function was impaired in testicular cancer survivors, while we did not detect any difference in the prevalence of metabolic syndrome between testicular cancer survivors and their biological brothers.
Andrology – Wiley
Published: Jul 1, 2017
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