Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides

Enrico Orsi; Jules Beekwilder; Dewi Gelder; Adèle Houwelingen; Gerrit Eggink; Servé W.M. Kengen; Ruud A. Weusthuis

doi:10.1111/1751-7915.13562

Loading next page...

References (78)

C. Kendig, T.T. Eckdahl (2017)
Reengineering metaphysics: modularity, parthood, and evolvability in metabolic engineering
, 9
F.M. Schempp, L. Drummond, M. Buchhaupt, J. Schrader (2017)
Microbial cell factories for the production of terpenoid flavor and fragrance compounds
, 66
( Vranová, E. , Coman, D. , and Gruissem, W. (2013) Network analysis of the MVA and MEP pathways for isoprenoid synthesis. Annu Rev Plant Biol 64: 665–700.23451776)
Vranová, E. , Coman, D. , and Gruissem, W. (2013) Network analysis of the MVA and MEP pathways for isoprenoid synthesis. Annu Rev Plant Biol 64: 665–700.23451776
Vranová, E. , Coman, D. , and Gruissem, W. (2013) Network analysis of the MVA and MEP pathways for isoprenoid synthesis. Annu Rev Plant Biol 64: 665–700.23451776, Vranová, E. , Coman, D. , and Gruissem, W. (2013) Network analysis of the MVA and MEP pathways for isoprenoid synthesis. Annu Rev Plant Biol 64: 665–700.23451776
J. Beekwilder, I.M. Meer, A. Simic, J. Uitdewilligen, J. Arkel, R.C.H. Vos (2008)
Metabolism of carotenoids and apocarotenoids during ripening of raspberry fruit
, 34
( Niu, F.X. , Lu, Q. , Bu, Y.F. , and Liu, J.Z. (2017) Metabolic engineering for the microbial production of isoprenoids: carotenoids and isoprenoid‐based biofuels. Synth Syst Biotechnol 2: 167–175.29318197)
Niu, F.X. , Lu, Q. , Bu, Y.F. , and Liu, J.Z. (2017) Metabolic engineering for the microbial production of isoprenoids: carotenoids and isoprenoid‐based biofuels. Synth Syst Biotechnol 2: 167–175.29318197
Niu, F.X. , Lu, Q. , Bu, Y.F. , and Liu, J.Z. (2017) Metabolic engineering for the microbial production of isoprenoids: carotenoids and isoprenoid‐based biofuels. Synth Syst Biotechnol 2: 167–175.29318197, Niu, F.X. , Lu, Q. , Bu, Y.F. , and Liu, J.Z. (2017) Metabolic engineering for the microbial production of isoprenoids: carotenoids and isoprenoid‐based biofuels. Synth Syst Biotechnol 2: 167–175.29318197
A. Flamholz, E. Noor, A. Bar‐Even, R. Milo (2012)
EQuilibrator – The biochemical thermodynamics calculator
, 40
( Schempp, F.M. , Drummond, L. , Buchhaupt, M. , and Schrader, J. (2017) Microbial cell factories for the production of terpenoid flavor and fragrance compounds. J Agric Food Chem 66: 2247–2258.28418659)
Schempp, F.M. , Drummond, L. , Buchhaupt, M. , and Schrader, J. (2017) Microbial cell factories for the production of terpenoid flavor and fragrance compounds. J Agric Food Chem 66: 2247–2258.28418659
Schempp, F.M. , Drummond, L. , Buchhaupt, M. , and Schrader, J. (2017) Microbial cell factories for the production of terpenoid flavor and fragrance compounds. J Agric Food Chem 66: 2247–2258.28418659, Schempp, F.M. , Drummond, L. , Buchhaupt, M. , and Schrader, J. (2017) Microbial cell factories for the production of terpenoid flavor and fragrance compounds. J Agric Food Chem 66: 2247–2258.28418659
P.K. Ajikumar, W.H. Xiao, K.E.J. Tyo, Y. Wang, F. Simeon, E. Leonard (2010)
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli
, 330
W. Bonacci, P.K. Teng, B. Afonso, H. Niederholtmeyer, P. Grob, P.A. Silver, D.F. Savage (2012)
Modularity of a carbon‐fixing protein organelle
, 109
( Peralta‐Yahya, P.P. , Zhang, F. , Cardayre, D.S.B. , and Keasling, J.D. (2012) Microbial engineering for the production of advanced biofuels. Nature 488: 320–328.22895337)
Peralta‐Yahya, P.P. , Zhang, F. , Cardayre, D.S.B. , and Keasling, J.D. (2012) Microbial engineering for the production of advanced biofuels. Nature 488: 320–328.22895337
Peralta‐Yahya, P.P. , Zhang, F. , Cardayre, D.S.B. , and Keasling, J.D. (2012) Microbial engineering for the production of advanced biofuels. Nature 488: 320–328.22895337, Peralta‐Yahya, P.P. , Zhang, F. , Cardayre, D.S.B. , and Keasling, J.D. (2012) Microbial engineering for the production of advanced biofuels. Nature 488: 320–328.22895337
(2016)
2016) Engineering a functional
J.C. Liao, L. Mi, S. Pontrelli, S. Luo (2016)
Fuelling the future: microbial engineering for the production of sustainable biofuels
, 14
( Zurbriggen, A. , Kirst, H. , and Melis, A. (2012) Isoprene production via the mevalonic acid pathway in Escherichia coli (Bacteria). Bioenergy Res 5: 814–828.)
Zurbriggen, A. , Kirst, H. , and Melis, A. (2012) Isoprene production via the mevalonic acid pathway in Escherichia coli (Bacteria). Bioenergy Res 5: 814–828.
Zurbriggen, A. , Kirst, H. , and Melis, A. (2012) Isoprene production via the mevalonic acid pathway in Escherichia coli (Bacteria). Bioenergy Res 5: 814–828., Zurbriggen, A. , Kirst, H. , and Melis, A. (2012) Isoprene production via the mevalonic acid pathway in Escherichia coli (Bacteria). Bioenergy Res 5: 814–828.
W. Lu, L. Ye, X. Lv, W. Xie, J. Gu, Z. Chen (2015)
Identification and elimination of metabolic bottlenecks in the quinone modification pathway for enhanced coenzyme Q 10 production in Rhodobacter sphaeroides
, 29
A. Zurbriggen, H. Kirst, A. Melis (2012)
Isoprene production via the mevalonic acid pathway in Escherichia coli (Bacteria)
, 5
( Grünler, J. , Ericsson, J. , and Dallner, G. (1994) Branch‐point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim Biophys Acta (BBA)/Lipids Lipid Metab 1212: 259–277.)
Grünler, J. , Ericsson, J. , and Dallner, G. (1994) Branch‐point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim Biophys Acta (BBA)/Lipids Lipid Metab 1212: 259–277.
Grünler, J. , Ericsson, J. , and Dallner, G. (1994) Branch‐point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim Biophys Acta (BBA)/Lipids Lipid Metab 1212: 259–277., Grünler, J. , Ericsson, J. , and Dallner, G. (1994) Branch‐point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim Biophys Acta (BBA)/Lipids Lipid Metab 1212: 259–277.
J. Beekwilder, A. Houwelingen, K. Cankar, A.D.J. Dijk, R.M. Jong, G. Stoopen (2014)
Valencene synthase from the heartwood of Nootka cypress (Callitropsis nootkatensis) for biotechnological production of valencene
, 12
( Benner, S.A. , and Sismour, A.M. (2005) Synthetic biology. Nat Rev Genet 6: 533–543.15995697)
Benner, S.A. , and Sismour, A.M. (2005) Synthetic biology. Nat Rev Genet 6: 533–543.15995697
Benner, S.A. , and Sismour, A.M. (2005) Synthetic biology. Nat Rev Genet 6: 533–543.15995697, Benner, S.A. , and Sismour, A.M. (2005) Synthetic biology. Nat Rev Genet 6: 533–543.15995697
( Lin, Z. , Cui, X. , Zhao, C. , Yang, S. , and Imhoff, J.F. (2014) Pigments accumulation via light and oxygen in Rhodobacter capsulatus strain XJ‐1 isolated from saline soil. J Basic Microbiol 54: 828–834.23686461)
Lin, Z. , Cui, X. , Zhao, C. , Yang, S. , and Imhoff, J.F. (2014) Pigments accumulation via light and oxygen in Rhodobacter capsulatus strain XJ‐1 isolated from saline soil. J Basic Microbiol 54: 828–834.23686461
Lin, Z. , Cui, X. , Zhao, C. , Yang, S. , and Imhoff, J.F. (2014) Pigments accumulation via light and oxygen in Rhodobacter capsulatus strain XJ‐1 isolated from saline soil. J Basic Microbiol 54: 828–834.23686461, Lin, Z. , Cui, X. , Zhao, C. , Yang, S. , and Imhoff, J.F. (2014) Pigments accumulation via light and oxygen in Rhodobacter capsulatus strain XJ‐1 isolated from saline soil. J Basic Microbiol 54: 828–834.23686461
( Chatzivasileiou, A.O. , Ward, V. , Edgar, S.M. , and Stephanopoulos, G. (2019) Two‐step pathway for isoprenoid synthesis. Proc Natl Acad Sci USA 116: 506–511.30584096)
Chatzivasileiou, A.O. , Ward, V. , Edgar, S.M. , and Stephanopoulos, G. (2019) Two‐step pathway for isoprenoid synthesis. Proc Natl Acad Sci USA 116: 506–511.30584096
Chatzivasileiou, A.O. , Ward, V. , Edgar, S.M. , and Stephanopoulos, G. (2019) Two‐step pathway for isoprenoid synthesis. Proc Natl Acad Sci USA 116: 506–511.30584096, Chatzivasileiou, A.O. , Ward, V. , Edgar, S.M. , and Stephanopoulos, G. (2019) Two‐step pathway for isoprenoid synthesis. Proc Natl Acad Sci USA 116: 506–511.30584096
( Lu, W. , Ye, L. , Lv, X. , Xie, W. , Gu, J. , Chen, Z. , et al (2015) Identification and elimination of metabolic bottlenecks in the quinone modification pathway for enhanced coenzyme Q 10 production in Rhodobacter sphaeroides . Metab Eng 29: 208–216.25817210)
Lu, W. , Ye, L. , Lv, X. , Xie, W. , Gu, J. , Chen, Z. , et al (2015) Identification and elimination of metabolic bottlenecks in the quinone modification pathway for enhanced coenzyme Q 10 production in Rhodobacter sphaeroides . Metab Eng 29: 208–216.25817210
Lu, W. , Ye, L. , Lv, X. , Xie, W. , Gu, J. , Chen, Z. , et al (2015) Identification and elimination of metabolic bottlenecks in the quinone modification pathway for enhanced coenzyme Q 10 production in Rhodobacter sphaeroides . Metab Eng 29: 208–216.25817210, Lu, W. , Ye, L. , Lv, X. , Xie, W. , Gu, J. , Chen, Z. , et al (2015) Identification and elimination of metabolic bottlenecks in the quinone modification pathway for enhanced coenzyme Q 10 production in Rhodobacter sphaeroides . Metab Eng 29: 208–216.25817210
( Mougiakos, I. , Orsi, E. , Ghiffari, M.R. , De Maria, A. , Post, W. , Adiego‐Perez, B. , et al (2019) Efficient Cas9‐based genome editing of Rhodobacter sphaeroides for metabolic engineering. Microb Cell Fact 18: 1–13.30609921)
Mougiakos, I. , Orsi, E. , Ghiffari, M.R. , De Maria, A. , Post, W. , Adiego‐Perez, B. , et al (2019) Efficient Cas9‐based genome editing of Rhodobacter sphaeroides for metabolic engineering. Microb Cell Fact 18: 1–13.30609921
Mougiakos, I. , Orsi, E. , Ghiffari, M.R. , De Maria, A. , Post, W. , Adiego‐Perez, B. , et al (2019) Efficient Cas9‐based genome editing of Rhodobacter sphaeroides for metabolic engineering. Microb Cell Fact 18: 1–13.30609921, Mougiakos, I. , Orsi, E. , Ghiffari, M.R. , De Maria, A. , Post, W. , Adiego‐Perez, B. , et al (2019) Efficient Cas9‐based genome editing of Rhodobacter sphaeroides for metabolic engineering. Microb Cell Fact 18: 1–13.30609921
A.O. Chatzivasileiou, V. Ward, S.M. Edgar, G. Stephanopoulos (2019)
Two‐step pathway for isoprenoid synthesis
, 116
F.K. Bentley, A. Zurbriggen, A. Melis (2014)
Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene
, 7
(2012)
A RubisCO-like protein links a 2020 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology
( Liao, J.C. , Mi, L. , Pontrelli, S. , and Luo, S. (2016) Fuelling the future: microbial engineering for the production of sustainable biofuels. Nat Rev Microbiol 14: 288–304.27026253)
Liao, J.C. , Mi, L. , Pontrelli, S. , and Luo, S. (2016) Fuelling the future: microbial engineering for the production of sustainable biofuels. Nat Rev Microbiol 14: 288–304.27026253
Liao, J.C. , Mi, L. , Pontrelli, S. , and Luo, S. (2016) Fuelling the future: microbial engineering for the production of sustainable biofuels. Nat Rev Microbiol 14: 288–304.27026253, Liao, J.C. , Mi, L. , Pontrelli, S. , and Luo, S. (2016) Fuelling the future: microbial engineering for the production of sustainable biofuels. Nat Rev Microbiol 14: 288–304.27026253
( Carlsen, S. , Ajikumar, P.K. , Formenti, L.R. , Zhou, K. , Phon, T.H. , Nielsen, M.L. , et al (2013) Heterologous expression and characterization of bacterial 2‐C‐methyl‐d‐erythritol‐4‐phosphate pathway in Saccharomyces cerevisiae . Appl Microbiol Biotechnol 97: 5753–5769.23636690)
Carlsen, S. , Ajikumar, P.K. , Formenti, L.R. , Zhou, K. , Phon, T.H. , Nielsen, M.L. , et al (2013) Heterologous expression and characterization of bacterial 2‐C‐methyl‐d‐erythritol‐4‐phosphate pathway in Saccharomyces cerevisiae . Appl Microbiol Biotechnol 97: 5753–5769.23636690
Carlsen, S. , Ajikumar, P.K. , Formenti, L.R. , Zhou, K. , Phon, T.H. , Nielsen, M.L. , et al (2013) Heterologous expression and characterization of bacterial 2‐C‐methyl‐d‐erythritol‐4‐phosphate pathway in Saccharomyces cerevisiae . Appl Microbiol Biotechnol 97: 5753–5769.23636690, Carlsen, S. , Ajikumar, P.K. , Formenti, L.R. , Zhou, K. , Phon, T.H. , Nielsen, M.L. , et al (2013) Heterologous expression and characterization of bacterial 2‐C‐methyl‐d‐erythritol‐4‐phosphate pathway in Saccharomyces cerevisiae . Appl Microbiol Biotechnol 97: 5753–5769.23636690
E. Orsi, J. Beekwilder, S. Peek, G. Eggink, S.W.M. Kengen, R.A. Weusthuis (2020)
Metabolic flux ratio analysis by parallel biosynthesis in Rhodobacter sphaeroides 13C labeling of isoprenoid
, 57
( Kendig, C. , and Eckdahl, T.T. (2017) Reengineering metaphysics: modularity, parthood, and evolvability in metabolic engineering. Philos Theory, Pract Biol 9: 1–21.)
Kendig, C. , and Eckdahl, T.T. (2017) Reengineering metaphysics: modularity, parthood, and evolvability in metabolic engineering. Philos Theory, Pract Biol 9: 1–21.
Kendig, C. , and Eckdahl, T.T. (2017) Reengineering metaphysics: modularity, parthood, and evolvability in metabolic engineering. Philos Theory, Pract Biol 9: 1–21., Kendig, C. , and Eckdahl, T.T. (2017) Reengineering metaphysics: modularity, parthood, and evolvability in metabolic engineering. Philos Theory, Pract Biol 9: 1–21.
S.T. Withers, J.D. Keasling (2007)
Biosynthesis and engineering of isoprenoid small molecules
, 73
M. Hümbelin, A. Thomas, J. Lin, J. Li, J. Jore, A. Berry (2002)
Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens
, 297
( Hümbelin, M. , Beekwilder, J. , and Kierkels, J. G. T. (2015) Rhodobacter for preparing terpenoids. Patent no. WO2014014339A3.)
Hümbelin, M. , Beekwilder, J. , and Kierkels, J. G. T. (2015) Rhodobacter for preparing terpenoids. Patent no. WO2014014339A3.
Hümbelin, M. , Beekwilder, J. , and Kierkels, J. G. T. (2015) Rhodobacter for preparing terpenoids. Patent no. WO2014014339A3., Hümbelin, M. , Beekwilder, J. , and Kierkels, J. G. T. (2015) Rhodobacter for preparing terpenoids. Patent no. WO2014014339A3.
G. Stephanopoulos (2012)
Synthetic biology and metabolic engineering
, 1
C.C. Liu, M.C. Jewett, J.W. Chin, C.A. Voigt (2018)
Toward an orthogonal central dogma
, 14
( Jiang, W. , Qiao, J.B. , Bentley, G.J. , Liu, D. , and Zhang, F. (2017) Modular pathway engineering for the microbial production of branched‐chain fatty alcohols. Biotechnol Biofuels 10: 1–15.28053662)
Jiang, W. , Qiao, J.B. , Bentley, G.J. , Liu, D. , and Zhang, F. (2017) Modular pathway engineering for the microbial production of branched‐chain fatty alcohols. Biotechnol Biofuels 10: 1–15.28053662
Jiang, W. , Qiao, J.B. , Bentley, G.J. , Liu, D. , and Zhang, F. (2017) Modular pathway engineering for the microbial production of branched‐chain fatty alcohols. Biotechnol Biofuels 10: 1–15.28053662, Jiang, W. , Qiao, J.B. , Bentley, G.J. , Liu, D. , and Zhang, F. (2017) Modular pathway engineering for the microbial production of branched‐chain fatty alcohols. Biotechnol Biofuels 10: 1–15.28053662
( Kirby, J. , Dietzel, K.L. , Wichmann, G. , Chan, R. , Antipov, E. , Moss, N. , et al (2016) Engineering a functional 1‐deoxy‐D‐xylulose 5‐phosphate (DXP) pathway in Saccharomyces cerevisiae . Metab Eng 38: 494–503.27989805)
Kirby, J. , Dietzel, K.L. , Wichmann, G. , Chan, R. , Antipov, E. , Moss, N. , et al (2016) Engineering a functional 1‐deoxy‐D‐xylulose 5‐phosphate (DXP) pathway in Saccharomyces cerevisiae . Metab Eng 38: 494–503.27989805
Kirby, J. , Dietzel, K.L. , Wichmann, G. , Chan, R. , Antipov, E. , Moss, N. , et al (2016) Engineering a functional 1‐deoxy‐D‐xylulose 5‐phosphate (DXP) pathway in Saccharomyces cerevisiae . Metab Eng 38: 494–503.27989805, Kirby, J. , Dietzel, K.L. , Wichmann, G. , Chan, R. , Antipov, E. , Moss, N. , et al (2016) Engineering a functional 1‐deoxy‐D‐xylulose 5‐phosphate (DXP) pathway in Saccharomyces cerevisiae . Metab Eng 38: 494–503.27989805
Z. Lin, X. Cui, C. Zhao, S. Yang, J.F. Imhoff (2014)
Pigments accumulation via light and oxygen in Rhodobacter capsulatus strain XJ‐1 isolated from saline soil
, 54
M. Hümbelin, J. Beekwilder, J. G. T. Kierkels (2015)
Rhodobacter for preparing terpenoids
( Ajikumar, P.K. , Xiao, W.H. , Tyo, K.E.J. , Wang, Y. , Simeon, F. , Leonard, E. , et al (2010) Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli . Science (80‐) 330: 70–74.)
Ajikumar, P.K. , Xiao, W.H. , Tyo, K.E.J. , Wang, Y. , Simeon, F. , Leonard, E. , et al (2010) Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli . Science (80‐) 330: 70–74.
Ajikumar, P.K. , Xiao, W.H. , Tyo, K.E.J. , Wang, Y. , Simeon, F. , Leonard, E. , et al (2010) Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli . Science (80‐) 330: 70–74., Ajikumar, P.K. , Xiao, W.H. , Tyo, K.E.J. , Wang, Y. , Simeon, F. , Leonard, E. , et al (2010) Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli . Science (80‐) 330: 70–74.
J. Lombard, D. Moreira (2011)
Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life
, 28
( Flamholz, A. , Noor, E. , Bar‐Even, A. , and Milo, R. (2012) EQuilibrator – The biochemical thermodynamics calculator. Nucleic Acids Res 40: 770–775.)
Flamholz, A. , Noor, E. , Bar‐Even, A. , and Milo, R. (2012) EQuilibrator – The biochemical thermodynamics calculator. Nucleic Acids Res 40: 770–775.
Flamholz, A. , Noor, E. , Bar‐Even, A. , and Milo, R. (2012) EQuilibrator – The biochemical thermodynamics calculator. Nucleic Acids Res 40: 770–775., Flamholz, A. , Noor, E. , Bar‐Even, A. , and Milo, R. (2012) EQuilibrator – The biochemical thermodynamics calculator. Nucleic Acids Res 40: 770–775.
( Bonacci, W. , Teng, P.K. , Afonso, B. , Niederholtmeyer, H. , Grob, P. , Silver, P.A. , and Savage, D.F. (2012) Modularity of a carbon‐fixing protein organelle. Proc Natl Acad Sci USA 109: 478–483.22184212)
Bonacci, W. , Teng, P.K. , Afonso, B. , Niederholtmeyer, H. , Grob, P. , Silver, P.A. , and Savage, D.F. (2012) Modularity of a carbon‐fixing protein organelle. Proc Natl Acad Sci USA 109: 478–483.22184212
Bonacci, W. , Teng, P.K. , Afonso, B. , Niederholtmeyer, H. , Grob, P. , Silver, P.A. , and Savage, D.F. (2012) Modularity of a carbon‐fixing protein organelle. Proc Natl Acad Sci USA 109: 478–483.22184212, Bonacci, W. , Teng, P.K. , Afonso, B. , Niederholtmeyer, H. , Grob, P. , Silver, P.A. , and Savage, D.F. (2012) Modularity of a carbon‐fixing protein organelle. Proc Natl Acad Sci USA 109: 478–483.22184212
E. Orsi, P.L. Folch, V.T. Monje‐López, B.M. Fernhout, A. Turcato, S.W.M. Kengen (2019)
Characterization of heterotrophic growth and sesquiterpene production by Rhodobacter sphaeroides on a defined medium
, 46
E. Orsi, J. Beekwilder, Siebe Peek, G. Eggink, S. Kengen, R. Weusthuis (2019)
Metabolic flux ratio analysis by parallel 13C labeling of isoprenoid biosynthesis in Rhodobacter sphaeroides.
Metabolic engineering
( Mewalal, R. , Rai, D.K. , Kainer, D. , Chen, F. , Külheim, C. , Peter, G.F. , and Tuskan, G.A. (2016) Plant‐derived terpenes: a feedstock for specialty biofuels. Trends Biotechnol 35: 227–240.27622303)
Mewalal, R. , Rai, D.K. , Kainer, D. , Chen, F. , Külheim, C. , Peter, G.F. , and Tuskan, G.A. (2016) Plant‐derived terpenes: a feedstock for specialty biofuels. Trends Biotechnol 35: 227–240.27622303
Mewalal, R. , Rai, D.K. , Kainer, D. , Chen, F. , Külheim, C. , Peter, G.F. , and Tuskan, G.A. (2016) Plant‐derived terpenes: a feedstock for specialty biofuels. Trends Biotechnol 35: 227–240.27622303, Mewalal, R. , Rai, D.K. , Kainer, D. , Chen, F. , Külheim, C. , Peter, G.F. , and Tuskan, G.A. (2016) Plant‐derived terpenes: a feedstock for specialty biofuels. Trends Biotechnol 35: 227–240.27622303
( Puan, K.J. , Wang, H. , Dairi, T. , Kuzuyama, T. , and Morita, C.T. (2005) fldA is an essential gene required in the 2‐C‐methyl‐D‐erythritol 4‐phosphate pathway for isoprenoid biosynthesis. FEBS Lett 579: 3802–3806.15978585)
Puan, K.J. , Wang, H. , Dairi, T. , Kuzuyama, T. , and Morita, C.T. (2005) fldA is an essential gene required in the 2‐C‐methyl‐D‐erythritol 4‐phosphate pathway for isoprenoid biosynthesis. FEBS Lett 579: 3802–3806.15978585
Puan, K.J. , Wang, H. , Dairi, T. , Kuzuyama, T. , and Morita, C.T. (2005) fldA is an essential gene required in the 2‐C‐methyl‐D‐erythritol 4‐phosphate pathway for isoprenoid biosynthesis. FEBS Lett 579: 3802–3806.15978585, Puan, K.J. , Wang, H. , Dairi, T. , Kuzuyama, T. , and Morita, C.T. (2005) fldA is an essential gene required in the 2‐C‐methyl‐D‐erythritol 4‐phosphate pathway for isoprenoid biosynthesis. FEBS Lett 579: 3802–3806.15978585
T.J. Erb, B.S. Evans, K. Cho, B.P. Warlick, J. Sriram, B.M.K. Wood (2012)
A RubisCO‐like protein links SAM metabolism with isoprenoid biosynthesis
, 8
R. Mewalal, D.K. Rai, D. Kainer, F. Chen, C. Külheim, G.F. Peter, G.A. Tuskan (2016)
Plant‐derived terpenes: a feedstock for specialty biofuels
, 35
( Bentley, F.K. , Zurbriggen, A. , and Melis, A. (2014) Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. Mol Plant 7: 71–86.24157609)
Bentley, F.K. , Zurbriggen, A. , and Melis, A. (2014) Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. Mol Plant 7: 71–86.24157609
Bentley, F.K. , Zurbriggen, A. , and Melis, A. (2014) Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. Mol Plant 7: 71–86.24157609, Bentley, F.K. , Zurbriggen, A. , and Melis, A. (2014) Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. Mol Plant 7: 71–86.24157609
( Partow, S. , Siewers, V. , Daviet, L. , Schalk, M. , and Nielsen, J. (2012) Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae . PLoS One 7: 1–12.)
Partow, S. , Siewers, V. , Daviet, L. , Schalk, M. , and Nielsen, J. (2012) Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae . PLoS One 7: 1–12.
Partow, S. , Siewers, V. , Daviet, L. , Schalk, M. , and Nielsen, J. (2012) Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae . PLoS One 7: 1–12., Partow, S. , Siewers, V. , Daviet, L. , Schalk, M. , and Nielsen, J. (2012) Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae . PLoS One 7: 1–12.
J. Kirby, J.D. Keasling (2009)
Biosynthesis of plant isoprenoids: perspectives for microbial engineering
, 60
( Orsi, E. , Beekwilder, J. , Peek, S. , Eggink, G. , Kengen, S.W.M. , and Weusthuis, R.A. (2020) Metabolic flux ratio analysis by parallel biosynthesis in Rhodobacter sphaeroides 13C labeling of isoprenoid. Metab Eng 57: 228–238.31843486)
Orsi, E. , Beekwilder, J. , Peek, S. , Eggink, G. , Kengen, S.W.M. , and Weusthuis, R.A. (2020) Metabolic flux ratio analysis by parallel biosynthesis in Rhodobacter sphaeroides 13C labeling of isoprenoid. Metab Eng 57: 228–238.31843486
Orsi, E. , Beekwilder, J. , Peek, S. , Eggink, G. , Kengen, S.W.M. , and Weusthuis, R.A. (2020) Metabolic flux ratio analysis by parallel biosynthesis in Rhodobacter sphaeroides 13C labeling of isoprenoid. Metab Eng 57: 228–238.31843486, Orsi, E. , Beekwilder, J. , Peek, S. , Eggink, G. , Kengen, S.W.M. , and Weusthuis, R.A. (2020) Metabolic flux ratio analysis by parallel biosynthesis in Rhodobacter sphaeroides 13C labeling of isoprenoid. Metab Eng 57: 228–238.31843486
W. Jiang, J.B. Qiao, G.J. Bentley, D. Liu, F. Zhang (2017)
Modular pathway engineering for the microbial production of branched‐chain fatty alcohols
, 10
P.K. Ajikumar, K. Tyo, S. Carlsen, O. Mucha, T.H. Phon, G. Stephanopoulos (2008)
Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms
, 5
( Beekwilder, J. , van Houwelingen, A. , Cankar, K. , van Dijk, A.D.J. , de Jong, R.M. , Stoopen, G. , et al (2014) Valencene synthase from the heartwood of Nootka cypress (Callitropsis nootkatensis) for biotechnological production of valencene. Plant Biotechnol J 12: 174–182.24112147)
Beekwilder, J. , van Houwelingen, A. , Cankar, K. , van Dijk, A.D.J. , de Jong, R.M. , Stoopen, G. , et al (2014) Valencene synthase from the heartwood of Nootka cypress (Callitropsis nootkatensis) for biotechnological production of valencene. Plant Biotechnol J 12: 174–182.24112147
Beekwilder, J. , van Houwelingen, A. , Cankar, K. , van Dijk, A.D.J. , de Jong, R.M. , Stoopen, G. , et al (2014) Valencene synthase from the heartwood of Nootka cypress (Callitropsis nootkatensis) for biotechnological production of valencene. Plant Biotechnol J 12: 174–182.24112147, Beekwilder, J. , van Houwelingen, A. , Cankar, K. , van Dijk, A.D.J. , de Jong, R.M. , Stoopen, G. , et al (2014) Valencene synthase from the heartwood of Nootka cypress (Callitropsis nootkatensis) for biotechnological production of valencene. Plant Biotechnol J 12: 174–182.24112147
( Lombard, J. , and Moreira, D. (2011) Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life. Mol Biol Evol 28: 87–99.20651049)
Lombard, J. , and Moreira, D. (2011) Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life. Mol Biol Evol 28: 87–99.20651049
Lombard, J. , and Moreira, D. (2011) Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life. Mol Biol Evol 28: 87–99.20651049, Lombard, J. , and Moreira, D. (2011) Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life. Mol Biol Evol 28: 87–99.20651049
( Stephanopoulos, G. (2012) Synthetic biology and metabolic engineering. ACS Synth Biol 1: 514–525.23656228)
Stephanopoulos, G. (2012) Synthetic biology and metabolic engineering. ACS Synth Biol 1: 514–525.23656228
Stephanopoulos, G. (2012) Synthetic biology and metabolic engineering. ACS Synth Biol 1: 514–525.23656228, Stephanopoulos, G. (2012) Synthetic biology and metabolic engineering. ACS Synth Biol 1: 514–525.23656228
( Zhou, K. , Qiao, K. , Edgar, S. , and Stephanopoulos, G. (2015) Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat Biotechnol 33: 377–383.25558867)
Zhou, K. , Qiao, K. , Edgar, S. , and Stephanopoulos, G. (2015) Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat Biotechnol 33: 377–383.25558867
Zhou, K. , Qiao, K. , Edgar, S. , and Stephanopoulos, G. (2015) Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat Biotechnol 33: 377–383.25558867, Zhou, K. , Qiao, K. , Edgar, S. , and Stephanopoulos, G. (2015) Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat Biotechnol 33: 377–383.25558867
S. Carlsen, P.K. Ajikumar, L.R. Formenti, K. Zhou, T.H. Phon, M.L. Nielsen (2013)
Heterologous expression and characterization of bacterial 2‐C‐methyl‐d‐erythritol‐4‐phosphate pathway in Saccharomyces cerevisiae
, 97
I. Mougiakos, E. Orsi, M.R. Ghiffari, A. De Maria, W. Post, B. Adiego‐Perez (2019)
Efficient Cas9‐based genome editing of Rhodobacter sphaeroides for metabolic engineering
, 18
P.P. Peralta‐Yahya, F. Zhang, D.S.B. Cardayre, J.D. Keasling (2012)
Microbial engineering for the production of advanced biofuels
, 488
( Wu, J. , Liu, P. , Fan, Y. , Bao, H. , Du, G. , Zhou, J. , and Chen, J. (2013) Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l‐tyrosine. J Biotechnol 167: 404–411.23916948)
Wu, J. , Liu, P. , Fan, Y. , Bao, H. , Du, G. , Zhou, J. , and Chen, J. (2013) Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l‐tyrosine. J Biotechnol 167: 404–411.23916948
Wu, J. , Liu, P. , Fan, Y. , Bao, H. , Du, G. , Zhou, J. , and Chen, J. (2013) Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l‐tyrosine. J Biotechnol 167: 404–411.23916948, Wu, J. , Liu, P. , Fan, Y. , Bao, H. , Du, G. , Zhou, J. , and Chen, J. (2013) Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l‐tyrosine. J Biotechnol 167: 404–411.23916948
S. Partow, V. Siewers, L. Daviet, M. Schalk, J. Nielsen (2012)
Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae
, 7
( Withers, S.T. , and Keasling, J.D. (2007) Biosynthesis and engineering of isoprenoid small molecules. Appl Microbiol Biotechnol 73: 980–990.17115212)
Withers, S.T. , and Keasling, J.D. (2007) Biosynthesis and engineering of isoprenoid small molecules. Appl Microbiol Biotechnol 73: 980–990.17115212
Withers, S.T. , and Keasling, J.D. (2007) Biosynthesis and engineering of isoprenoid small molecules. Appl Microbiol Biotechnol 73: 980–990.17115212, Withers, S.T. , and Keasling, J.D. (2007) Biosynthesis and engineering of isoprenoid small molecules. Appl Microbiol Biotechnol 73: 980–990.17115212
K. Polizzi (2013)
What is synthetic biology?
Methods in molecular biology, 1073
J. Kirby, M. Nishimoto, R.W.N. Chow, E.E.K. Baidoo, G. Wang, J. Martin (2015)
Enhancing Terpene yield from sugars via novel routes to 1‐deoxy‐D‐xylulose 5‐phosphate
, 81
S.A. Benner, A.M. Sismour (2005)
Synthetic biology
, 6
L. Loiseau, C. Gerez, M. Bekker, S. Ollagnier‐De Choudens, B. Py, Y. Sanakis (2007)
ErpA, an iron‐sulfur (Fe‐S) protein of the A‐type essential for respiratory metabolism in Escherichia coli
, 104
E. Vranová, D. Coman, W. Gruissem (2013)
Network analysis of the MVA and MEP pathways for isoprenoid synthesis
, 64
J. Wu, P. Liu, Y. Fan, H. Bao, G. Du, J. Zhou, J. Chen (2013)
Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l‐tyrosine
, 167
( Erb, T.J. , Evans, B.S. , Cho, K. , Warlick, B.P. , Sriram, J. , Wood, B.M.K. , et al (2012) A RubisCO‐like protein links SAM metabolism with isoprenoid biosynthesis. Nat Chem Biol 8: 926–932.23042035)
Erb, T.J. , Evans, B.S. , Cho, K. , Warlick, B.P. , Sriram, J. , Wood, B.M.K. , et al (2012) A RubisCO‐like protein links SAM metabolism with isoprenoid biosynthesis. Nat Chem Biol 8: 926–932.23042035
Erb, T.J. , Evans, B.S. , Cho, K. , Warlick, B.P. , Sriram, J. , Wood, B.M.K. , et al (2012) A RubisCO‐like protein links SAM metabolism with isoprenoid biosynthesis. Nat Chem Biol 8: 926–932.23042035, Erb, T.J. , Evans, B.S. , Cho, K. , Warlick, B.P. , Sriram, J. , Wood, B.M.K. , et al (2012) A RubisCO‐like protein links SAM metabolism with isoprenoid biosynthesis. Nat Chem Biol 8: 926–932.23042035
J. Grünler, J. Ericsson, G. Dallner (1994)
Branch‐point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins
, 1212
K.J. Puan, H. Wang, T. Dairi, T. Kuzuyama, C.T. Morita (2005)
fldA is an essential gene required in the 2‐C‐methyl‐D‐erythritol 4‐phosphate pathway for isoprenoid biosynthesis
, 579
J. Kirby, K.L. Dietzel, G. Wichmann, R. Chan, E. Antipov, N. Moss (2016)
Engineering a functional 1‐deoxy‐D‐xylulose 5‐phosphate (DXP) pathway in Saccharomyces cerevisiae
, 38
F.X. Niu, Q. Lu, Y.F. Bu, J.Z. Liu (2017)
Metabolic engineering for the microbial production of isoprenoids: carotenoids and isoprenoid‐based biofuels
, 2
( Liu, C.C. , Jewett, M.C. , Chin, J.W. , and Voigt, C.A. (2018) Toward an orthogonal central dogma. Nat Chem Biol 14: 103–106.29337969)
Liu, C.C. , Jewett, M.C. , Chin, J.W. , and Voigt, C.A. (2018) Toward an orthogonal central dogma. Nat Chem Biol 14: 103–106.29337969
Liu, C.C. , Jewett, M.C. , Chin, J.W. , and Voigt, C.A. (2018) Toward an orthogonal central dogma. Nat Chem Biol 14: 103–106.29337969, Liu, C.C. , Jewett, M.C. , Chin, J.W. , and Voigt, C.A. (2018) Toward an orthogonal central dogma. Nat Chem Biol 14: 103–106.29337969
K. Zhou, K. Qiao, S. Edgar, G. Stephanopoulos (2015)
Distributing a metabolic pathway among a microbial consortium enhances production of natural products
, 33
( Loiseau, L. , Gerez, C. , Bekker, M. , Ollagnier‐De Choudens, S. , Py, B. , Sanakis, Y. , et al (2007) ErpA, an iron‐sulfur (Fe‐S) protein of the A‐type essential for respiratory metabolism in Escherichia coli . Proc Natl Acad Sci USA 104: 13626–13631.17698959)
Loiseau, L. , Gerez, C. , Bekker, M. , Ollagnier‐De Choudens, S. , Py, B. , Sanakis, Y. , et al (2007) ErpA, an iron‐sulfur (Fe‐S) protein of the A‐type essential for respiratory metabolism in Escherichia coli . Proc Natl Acad Sci USA 104: 13626–13631.17698959
Loiseau, L. , Gerez, C. , Bekker, M. , Ollagnier‐De Choudens, S. , Py, B. , Sanakis, Y. , et al (2007) ErpA, an iron‐sulfur (Fe‐S) protein of the A‐type essential for respiratory metabolism in Escherichia coli . Proc Natl Acad Sci USA 104: 13626–13631.17698959, Loiseau, L. , Gerez, C. , Bekker, M. , Ollagnier‐De Choudens, S. , Py, B. , Sanakis, Y. , et al (2007) ErpA, an iron‐sulfur (Fe‐S) protein of the A‐type essential for respiratory metabolism in Escherichia coli . Proc Natl Acad Sci USA 104: 13626–13631.17698959

Publisher: Wiley
eISSN: 1751-7915
DOI: 10.1111/1751-7915.13562
Publisher site: See Article on Publisher Site

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides

Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides

Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides

References (78)

Abstract

Journal

Recommended Articles

There are no references for this article.

Our policy towards the use of cookies