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Epithelial-Myoepithelial Carcinoma With High Grade Transformation

Epithelial-Myoepithelial Carcinoma With High Grade Transformation Downloaded from http://journals.lww.com/ajsp by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/11/2020 ORIGINAL ARTICLE Epithelial-Myoepithelial Carcinoma With High Grade Transformation Paromita Roy, MD,*w Martin J. Bullock, MD,z Bayardo Perez-Ordon˜ez, MD,*w Irving Dardick, MD,*w and Ilan Weinreb, MD*w pithelial-myoepithelial carcinoma (EMC) is a rare Abstract: Epithelial-myoepithelial carcinoma (EMC) is a rare Esalivary gland malignancy of presumed intercalated salivary gland tumor of presumed intercalated duct origin with a duct origin comprising 1% of all salivary gland tumors. low risk of metastasis and mortality. Factors shown to affect The name, first used by Donath et al in 1972, denotes a behavior include positive margins, vascular invasion, necrosis, biphasic tubular neoplasm of clear myoepithelial cells and myoepithelial anaplasia. The latter category and dediffer- surrounding small lumina lined by ductal epithelial cells. entiated EMCs have been separated on the basis of presumed Classically, this is a low-grade malignancy, mainly myoepithelial versus ductal origin, respectively. Three additional occurring in the parotid gland, but it may also occur at cases of typical EMC with transition to high-grade carcinoma any minor salivary or seromucous gland site, including 8,19 are presented. Two of the tumors were stained with CAM5.2, the upper and lower respiratory tract. The architecture 34bE12, cytokeratin 14, p63, S100, calponin, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Surgical Pathology Wolters Kluwer Health

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Publisher
Wolters Kluwer Health
ISSN
0147-5185
eISSN
1532-0979
DOI
10.1097/PAS.0b013e3181e366d2
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/ajsp by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/11/2020 ORIGINAL ARTICLE Epithelial-Myoepithelial Carcinoma With High Grade Transformation Paromita Roy, MD,*w Martin J. Bullock, MD,z Bayardo Perez-Ordon˜ez, MD,*w Irving Dardick, MD,*w and Ilan Weinreb, MD*w pithelial-myoepithelial carcinoma (EMC) is a rare Abstract: Epithelial-myoepithelial carcinoma (EMC) is a rare Esalivary gland malignancy of presumed intercalated salivary gland tumor of presumed intercalated duct origin with a duct origin comprising 1% of all salivary gland tumors. low risk of metastasis and mortality. Factors shown to affect The name, first used by Donath et al in 1972, denotes a behavior include positive margins, vascular invasion, necrosis, biphasic tubular neoplasm of clear myoepithelial cells and myoepithelial anaplasia. The latter category and dediffer- surrounding small lumina lined by ductal epithelial cells. entiated EMCs have been separated on the basis of presumed Classically, this is a low-grade malignancy, mainly myoepithelial versus ductal origin, respectively. Three additional occurring in the parotid gland, but it may also occur at cases of typical EMC with transition to high-grade carcinoma any minor salivary or seromucous gland site, including 8,19 are presented. Two of the tumors were stained with CAM5.2, the upper and lower respiratory tract. The architecture 34bE12, cytokeratin 14, p63, S100, calponin,

Journal

American Journal of Surgical PathologyWolters Kluwer Health

Published: Sep 1, 2010

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