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Thrombin generation and thromboelastometry in monitoring the in-vitro reversal of warfarin: a comparison between 3-factor and 4-factor prothrombin complex concentrates

Thrombin generation and thromboelastometry in monitoring the in-vitro reversal of warfarin: a... Downloaded from http://journals.lww.com/bloodcoagulation by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/01/2020 Original article 127 Thrombin generation and thromboelastometry in monitoring the in-vitro reversal of warfarin: a comparison between 3-factor and 4-factor prothrombin complex concentrates Luca Spiezia, Valeria Rossetto, Elena Campello, Cristiana Bulato, Claudia M. Radu and Paolo Simioni preliminary phase were confirmed in the validation phase. The efficacy of three-factor prothrombin complex 3-PCC appears to be as effective as 4-PCC in reversing oral concentrates (PCCs) in the reversal of vitamin K antagonists is still a matter of debate. We compared the ‘in-vitro’ effect of anticoagulant treatment based on thrombin generation and three PCCs (one three-factor and two four-factor) on EXTEM data, but not INR data, at least in the range of INR considered in our study. Further studies are needed to international normalized ratio (INR), thrombin generation and thromboelastometry of patients at different degrees of address the clinical implications of our results. Blood anticoagulation with vitamin K antagonist. We tested three Coagul Fibrinolysis 31:127–131 Copyright  2020 Wolters Kluwer Health, Inc. All rights reserved. concentrations of PCC (0.5, 1 and 1.5 U/ml) in six patients: three (INR 2.0–2.9) and three (INR 3.0–4.0). In this preliminary phase, we determined the lowest effective dose for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Blood Coagulation & Fibrinolysis Wolters Kluwer Health

Thrombin generation and thromboelastometry in monitoring the in-vitro reversal of warfarin: a comparison between 3-factor and 4-factor prothrombin complex concentrates

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Publisher
Wolters Kluwer Health
ISSN
0957-5235
eISSN
1473-5733
DOI
10.1097/MBC.0000000000000887
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Abstract

Downloaded from http://journals.lww.com/bloodcoagulation by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/01/2020 Original article 127 Thrombin generation and thromboelastometry in monitoring the in-vitro reversal of warfarin: a comparison between 3-factor and 4-factor prothrombin complex concentrates Luca Spiezia, Valeria Rossetto, Elena Campello, Cristiana Bulato, Claudia M. Radu and Paolo Simioni preliminary phase were confirmed in the validation phase. The efficacy of three-factor prothrombin complex 3-PCC appears to be as effective as 4-PCC in reversing oral concentrates (PCCs) in the reversal of vitamin K antagonists is still a matter of debate. We compared the ‘in-vitro’ effect of anticoagulant treatment based on thrombin generation and three PCCs (one three-factor and two four-factor) on EXTEM data, but not INR data, at least in the range of INR considered in our study. Further studies are needed to international normalized ratio (INR), thrombin generation and thromboelastometry of patients at different degrees of address the clinical implications of our results. Blood anticoagulation with vitamin K antagonist. We tested three Coagul Fibrinolysis 31:127–131 Copyright  2020 Wolters Kluwer Health, Inc. All rights reserved. concentrations of PCC (0.5, 1 and 1.5 U/ml) in six patients: three (INR 2.0–2.9) and three (INR 3.0–4.0). In this preliminary phase, we determined the lowest effective dose for

Journal

Blood Coagulation & Fibrinolysis – Wolters Kluwer Health

Published: Mar 1, 2020

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