Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Garrido, Carlota Gutiérrez, E. Riveiro‐Falkenbach, P. Ortiz, J. Rodríguez-Peralto (2015)
BRAF Inhibitor-Induced Antitumoral Granulomatous Dermatitis Eruption in Advanced Melanoma.The American Journal of dermatopathology, 37 10
D. Valeyre, A. Prasse, H. Nunes, Y. Uzunhan, Pierre-Yves Brillet, J. Müller‐Quernheim (2014)
SarcoidosisThe Lancet, 383
J. Wilmott, L. Haydu, A. Menzies, T. Lum, J. Hyman, J. Thompson, P. Hersey, R. Kefford, R. Scolyer, G. Long (2014)
Dynamics of Chemokine, Cytokine, and Growth Factor Serum Levels in BRAF-Mutant Melanoma Patients during BRAF Inhibitor TreatmentThe Journal of Immunology, 192
A. Adam, L. Thomas, N. Bories, D. Zaharia, B. Balme, N. Freymond, S. Dalle (2013)
Sarcoidosis associated with vemurafenibBritish Journal of Dermatology, 169
J. Green, David Norris, Joshua Wisell (2013)
Novel cutaneous effects of combination chemotherapy with BRAF and MEK inhibitors: a report of two casesBritish Journal of Dermatology, 169
B. Beutler, Philip Cohen, C. Lee (2015)
Sarcoidosis in Melanoma Patients: Case Report and Literature ReviewCancers, 7
Y. Jansen, P. Janssens, A. Hoorens, M. Schreuer, T. Seremet, S. Wilgenhof, B. Neyns (2015)
Granulomatous nephritis and dermatitis in a patient with BRAF V600E mutant metastatic melanoma treated with dabrafenib and trametinib.Melanoma research, 25 6
Nisha Ramani, J. Curry, J. Kapil, R. Rapini, M. Tetzlaff, V. Prieto, C. Torres‐Cabala (2015)
Panniculitis With Necrotizing Granulomata in a Patient on BRAF Inhibitor (Dabrafenib) Therapy for Metastatic Melanoma.The American Journal of dermatopathology, 37 8
F. Dimitriou, A. Frauchiger, M. Urosevic-Maiwald, Mirjam Naegeli, S. Goldinger, M. Barysch, D. Franzen, J. Kamarachev, R. Braun, R. Dummer, J. Mangana (2018)
Sarcoid-like reactions in patients receiving modern melanoma treatmentMelanoma Research, 28
G. Giet, E. Lebas, A. Rorive, J. Arrese, A. Nikkels (2019)
Granulomatous Reactions from Tattoos Following BRAF Inhibitor TherapyCase Reports in Dermatology, 11
J. Winkler, K. Buder-Bakhaya, E. Ellert, E. Herpel, U. Martens, A. Enk, J. Hassel (2018)
Acute heart failure as a result of granulomatous myocarditis: case report on a patient with metastatic melanoma treated with dabrafenib and trametinibJournal of the European Academy of Dermatology and Venereology, 32
C. Lheure, N. Kramkimel, N. Franck, S. Laurent-Roussel, A. Carlotti, Astrid Quéant, F. Goldwasser, M. Avril, N. Dupin (2015)
Sarcoidosis in Patients Treated with Vemurafenib for Metastatic Melanoma: A Paradoxical Autoimmune ActivationDermatology, 231
L. Leal, E. Agut-Busquet, J. Romaní, M. Sabat, M. Yébenes, A. Sáez, J. Luelmo (2016)
Cutaneous granulomatous panniculitis and sarcoidal granulomatous papular eruption in a patient with metastatic melanoma treated with a BRAF inhibitorThe Journal of Dermatology, 43
G. Tchernev, C. Tana, C. Schiavone, J. Cardoso, J. Ananiev, U. Wollina (2014)
Sarcoidosis vs. Sarcoid-like reactions: The Two Sides of the same Coin?Wiener Medizinische Wochenschrift, 164
L. Zimmer, E. Livingstone, U. Hillen, Stephanie Dömkes, A. Becker, D. Schadendorf (2012)
Panniculitis with arthralgia in patients with melanoma treated with selective BRAF inhibitors and its management.Archives of dermatology, 148 3
June Park, E. Hawryluk, S. Tahan, K. Flaherty, Caroline Kim (2014)
Cutaneous granulomatous eruption and successful response to potent topical steroids in patients undergoing targeted BRAF inhibitor treatment for metastatic melanoma.JAMA dermatology, 150 3
T. Rueda-Rueda, J. Sánchez-Vicente, A. Moruno-Rodríguez, F. Molina-Sócola, A. Martínez-Borrego, F. López-Herrero (2018)
Uveitis and serous retinal detachment secondary to systemic dabrafenib and trametinib.Archivos de la Sociedad Espanola de Oftalmologia, 93 9
Erin Spengler, D. Kleiner, R. Fontana (2017)
Vemurafenib‐induced granulomatous hepatitisHepatology, 65
Combined BRAF and MEK inhibition is one of the first-line treatment strategies for patients with advanced BRAF-mutant melanoma. Sarcoid-like reactions (SLRs) have occasionally been described with melanoma systemic treatments such as immunotherapy or the BRAF inhibitor vemurafenib, but very few cases have been reported with dabrafenib and trametinib. Our aim was to better characterize SLR induced by this combination. We conducted a monocentric retrospective observational study among patients treated with dabrafenib and trametinib for BRAF-mutant advanced melanoma from January 2015 to March 2019. Patients presenting with histologically proven SLR were included. We also searched Medline database for all reported cases of SLR induced by targeted therapy. Of 63 patients on dabrafenib/trametinib combination, seven were diagnosed with a SLR. They all had specific cutaneous involvement, and one also displayed mediastinal and salivary glands involvement. None required systemic corticosteroids or dabrafenib/trametinib discontinuation. Three of them (43%) reached melanoma complete remission and are still on targeted therapy; and four patients progressed and died. A literature review yielded 22 additional cases of SLR induced by targeted therapy: the main affected organ was the skin, 11 patients (50%) had systemic involvement, five patients (23%) required systemic corticosteroids to reach partial or complete remission of SLR, 12 (55%) reached partial or complete response of melanoma while six (27%) progressed. BRAF and MEK inhibitors are potential triggers of SLR, although pathological mechanisms remain unclear. The mainstay of treatment is systemic or topical corticotherapy; targeted therapy discontinuation is usually not necessary.
Melanoma Research – Wolters Kluwer Health
Published: Jun 1, 2020
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.