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B. Chaffee, Jing Cheng (2018)
Cigarette and Smokeless Tobacco Perception Differences of Rural Male Youth.Tobacco regulatory science, 4 4
Brian Rostron, Cindy Chang, Dana Bemmel, Yang Xia, B. Blount (2015)
Nicotine and Toxicant Exposure among U.S. Smokeless Tobacco Users: Results from 1999 to 2012 National Health and Nutrition Examination Survey DataCancer Epidemiology, Biomarkers & Prevention, 24
S. Carmella, Shaomei Han, Anne Fristad, Yiying Yang, S. Hecht (2003)
Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 12 11 Pt 1
L. Kann (1995)
Youth Risk Behavior Surveillance--United States, 1993. CDC Surveillance Summaries.Morbidity and Mortality Weekly Report, 44
Herbert Severson, K. Klein, E. Lichtensein, N. Kaufman, C. Orleans (2005)
Smokeless tobacco use among professional baseball players: survey results, 1998 to 2003Tobacco Control, 14
S. Hecht (1998)
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.Chemical research in toxicology, 11 6
M. Hewitt (1989)
Defining "Rural" Areas: Impact on Health Care Policy and Research. Staff Paper.
(2016)
Can Major League Baseball really rid itself of smokeless tobacco?
P. Jacob, Lisa Yu, M. Duan, Lita Ramos, Olivia Yturralde, N. Benowitz (2011)
Determination of the nicotine metabolites cotinine and trans-3'-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography-tandem mass spectrometry: biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 3-4
Teresa Wang, Andrea Gentzke, Saida Sharapova, K. Cullen, Bridget Ambrose, Ahmed Jamal (2018)
Tobacco Product Use Among Middle and High School Students — United States, 2011–2017Morbidity and Mortality Weekly Report, 67
P. Jacob, C. Havel, Do-Hoon Lee, Lisa Yu, M. Eisner, N. Benowitz (2008)
Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry.Analytical chemistry, 80 21
S. Hecht, S. Carmella, Amanda Edmonds, S. Murphy, I. Stepanov, Xianghua Luo, D. Hatsukami (2008)
Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobaccoTobacco Control, 17
G. Connolly, C. Orleans, A. Blum (1992)
Snuffing tobacco out of sport.American journal of public health, 82 3
S. Hecht, A. Rivenson, J. Braley, Joann DiBello, J. Adams, D. Hoffmann (1986)
Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff.Cancer research, 46 8
B. Chaffee, E. Couch, S. Gansky (2018)
Adolescents' smokeless tobacco susceptibility by perceived professional baseball players' useJournal of Public Health Dentistry, 78
M. Walsh, J. Hilton, V. Ernster, C. Masouredis, D. Grady (1994)
Prevalence, patterns, and correlates of spit tobacco use in a college athlete population.Addictive behaviors, 19 4
Megan Roberts, N. Doogan, C. Stanton, Amanda Quisenberry, Andrea Villanti, D. Gaalema, D. Keith, Allison Kurti, Alexa Lopez, R. Redner, A. Cepeda-Benito, S. Higgins (2017)
Rural Versus Urban Use of Traditional and Emerging Tobacco Products in the United States, 2013-2014American Journal of Public Health, 107
P. Richter, Knachelle Hodge, S. Stanfill, Liqin Zhang, C. Watson (2008)
Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 10 11
I. Stepanov, Joni Jensen, D. Hatsukami, S. Hecht (2006)
Tobacco-specific nitrosamines in new tobacco products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 8 2
Tameka Lawler, S. Stanfill, Liqin Zhang, D. Ashley, C. Watson (2013)
Chemical characterization of domestic oral tobacco products: total nicotine, pH, unprotonated nicotine and tobacco-specific N-nitrosamines.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 57
(2016)
US Food Drug Administration. Tobacco Product Standard for N-Nitrosonornicotine Level in Finished Smokeless Tobacco Products (proposed Rule)
L. Kann, Tim Mcmanus, W. Harris, S. Shanklin, K. Flint, Barbara Queen, R. Lowry, David Chyen, L. Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, N. Brener, K. Ethier (2018)
Youth Risk Behavior Surveillance — United States, 2017MMWR Surveillance Summaries, 67
S. Hecht, S. Carmella, S. Murphy, W. Riley, C. Le, Xianghua Luo, Marc Mooney, D. Hatsukami (2007)
Similar Exposure to a Tobacco-Specific Carcinogen in Smokeless Tobacco Users and Cigarette SmokersCancer Epidemiology Biomarkers & Prevention, 16
Dorothy Hatsukami, I. Stepanov, Herb Severson, Joni Jensen, Bruce Lindgren, Kimberly Horn, Samir Khariwala, Julia Martin, S. Carmella, Sharon Murphy, Stephen Hecht (2014)
Evidence Supporting Product Standards for Carcinogens in Smokeless Tobacco ProductsCancer Prevention Research, 8
M. Goniewicz, C. Havel, M. Peng, P. Jacob, D. Dempsey, Lisa Yu, W. Zielińska-Danch, Bartosz Koszowski, J. Czogała, A. Sobczak, N. Benowitz (2009)
Elimination Kinetics of the Tobacco-Specific Biomarker and Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-ButanolCancer Epidemiology, Biomarkers & Prevention, 18
I. Agaku, C. Vardavas, G. Connolly (2013)
Proposed cutoff for identifying adult smokeless tobacco users with urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol: an aggregated analysis of NHANES 2007-2010 data.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 15 11
Andrea Gentzke, MeLisa Creamer, K. Cullen, Bridget Ambrose, G. Willis, Ahmed Jamal, Brian King (2019)
Vital Signs: Tobacco Product Use Among Middle and High School Students — United States, 2011–2018Morbidity and Mortality Weekly Report, 68
Dr Hyland, Bridget Ambrose, K. Conway, Nicolette Borek, Elizabeth Lambert, Charles Carusi, Kristie Taylor, Scott Crosse, Geoffrey Fong, Michael Cummings, D. Abrams, J. Pierce, J. Sargent, K. Messer, M. Bansal-Travers, R. Niaura, D. Vallone, David Hammond, Nahla Hilmi, Jonathan Kwan, Andrea Piesse, G. Kalton, S. Lohr, Nick Pharris-Ciurej, Victoria Castleman, Victoria Green, Greta Tessman, Annette Kaufman, Charles Lawrence, D. Bemmel, H. Kimmel, Ben Blount, Ling Yang, Barbara Brien, C. Tworek, Derek Alberding, Lynn Hull, Yu-Ching Cheng, D. Maklan, C. Backinger, W. Compton (2016)
Design and methods of the Population Assessment of Tobacco and Health (PATH) StudyTobacco Control, 26
K. Kasza, Bridget Ambrose, K. Conway, Nicolette Borek, Kristie Taylor, M. Goniewicz, K. Cummings, E. Sharma, Jennifer Pearson, Victoria Green, Annette Kaufman, M. Bansal-Travers, M. Travers, Jonathan Kwan, C. Tworek, Yu-Ching Cheng, Ling Yang, Nikolas Pharris-Ciurej, Dana Bemmel, C. Backinger, W. Compton, A. Hyland (2017)
Tobacco‐Product Use by Adults and Youths in the United States in 2013 and 2014The New England Journal of Medicine, 376
M. Walsh, J. Ellison, J. Hilton, M. Chesney, V. Ernster (2000)
Spit (smokeless) tobacco use by high school baseball athletes in CaliforniaTobacco Control, 9
J. Hukkanen, Pleyton Jacob, N. Benowitz (2005)
Metabolism and Disposition Kinetics of NicotinePharmacological Reviews, 57
P. Rhodes (1933)
Administration.British Medical Journal (Clinical research ed.), 286
(2007)
Smokeless tobacco and some tobacco-specific N-nitrosamines.IARC monographs on the evaluation of carcinogenic risks to humans, 89
S. Warnakulasuriya, T. Dietrich, M. Bornstein, E. Peidró, P. Preshaw, C. Walter, J. Wennström, J. Bergström (2010)
Oral health risks of tobacco use and effects of cessation.International dental journal, 60 1
I. Stepanov, L. Biener, Aleksandar Knezevich, A. Nyman, R. Bliss, Joni Jensen, S. Hecht, D. Hatsukami (2012)
Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product Watch.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 14 3
B. Osterdahl, C. Jansson, A. Paccou (2004)
Decreased levels of tobacco-specific N-nitrosamines in moist snuff on the Swedish market.Journal of agricultural and food chemistry, 52 16
R. Mehrotra, A. Yadav, D. Sinha, M. Parascandola, R. John, O. Ayo-Yusuf, N. Nargis, D. Hatsukami, S. Warnakulasuriya, K. Straif, K. Siddiqi, Prakash Gupta (2019)
Smokeless tobacco control in 180 countries across the globe: call to action for full implementation of WHO FCTC measures.The Lancet. Oncology, 20 4
S. Gansky, J. Ellison, C. Kavanagh, Umo Isong, M. Walsh (2009)
Patterns and correlates of spit tobacco use among high school males in rural California.Journal of public health dentistry, 69 2
P. Boffetta, S. Hecht, N. Gray, P. Gupta, K. Straif (2008)
Smokeless tobacco and cancer.The Lancet. Oncology, 9 7
G. Connolly (1995)
The marketing of nicotine addiction by one oral snuff manufacturer, 4
S. Hecht, I. Stepanov, S. Carmella (2016)
Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.Accounts of chemical research, 49 1
D. Hatsukami, J. Ebbert, A. Anderson, H. Lin, C. Le, S. Hecht (2007)
Smokeless tobacco brand switching: a means to reduce toxicant exposure?Drug and alcohol dependence, 87 2-3
K. Diehl, A. Thiel, S. Zipfel, J. Mayer, D. Litaker, S. Schneider (2012)
How Healthy is the Behavior of Young Athletes? A Systematic Literature Review and Meta-Analyses.Journal of sports science & medicine, 11 2
N. Benowitz, N. Nardone, Shonul Jain, D. Dempsey, N. Addo, G. Helen, P. Jacob (2018)
Comparison of Urine 4-(Methylnitrosamino)-1-(3)Pyridyl-1-Butanol and Cotinine for Assessment of Active and Passive Smoke Exposure in Urban AdolescentsCancer Epidemiology, Biomarkers & Prevention, 27
A. Wyss, M. Hashibe, Y. Lee, Shu-Chun Chuang, J. Muscat, Chu Chen, S. Schwartz, E. Smith, Zuo‐Feng Zhang, H. Morgenstern, Q. Wei, Guojun Li, K. Kelsey, M. McClean, D. Winn, S. Schantz, Guo-Pei Yu, M. Gillison, J. Zevallos, P. Boffetta, A. Olshan (2016)
Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium.American journal of epidemiology, 184 10
Abstract Introduction Approximately the same percentage of male high school students in the United States currently uses conventional smokeless tobacco as smokes cigarettes, resulting in toxin exposure. Methods This study assessed tobacco product use (smokeless, combustible, and electronic cigarettes) and nicotine and carcinogen exposures in a sample of 594 male rural high school baseball players - a population traditionally at risk for smokeless tobacco use. Salivary specimens were assayed for cotinine (a biomarker of nicotine exposure) and urine specimens for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, a biomarker of the carcinogen NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) using liquid chromatography-tandem mass spectrometry. Results The prevalence of past 30-day use of any tobacco product was 29%. Past 7-day smokeless tobacco use (prevalence: 13%) was associated with the highest levels of cotinine and NNAL observed in the sample, whether smokeless tobacco was used exclusively (geometric means: cotinine 11.1 ng/ml; NNAL 31.9 pg/mg-creatinine) or in combination with combustible products (geometric means: cotinine 31.6 ng/ml; NNAL 50.0 pg/mg-creatinine). Cotinine and NNAL levels were incrementally higher in each increasing category of smokeless tobacco use frequency. However, observed levels were lower than previously reported for adults, likely reflecting less smokeless use per day among adolescents. Conclusions Based on these biomarker observations, adolescents who use conventional smokeless tobacco products are exposed to substantial levels of nicotine and NNK. Although exposed to lower levels than adult smokeless users, the findings are concerning given the young age of the sample and tendency for smokeless tobacco users to increase use intensity over time. Implications This study demonstrates that adolescents using smokeless tobacco are exposed to levels of nicotine and NNK that increase with use frequency and that exceed exposures among peers using other tobacco products. Youth smokeless tobacco use in the U.S. has not declined along with youth smoking prevalence, giving greater importance to this health concern. To reduce youth (and adult) exposures, needed actions include effective smokeless tobacco use prevention, potentially in combination with reducing the levels of harmful and potentially harmful chemicals in smokeless tobacco products currently popular among adolescents. This content is only available as a PDF. © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Nicotine and Tobacco Research – Oxford University Press
Published: Jan 1, 2004
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