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Nathan
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Journal of clinical epidemiology, 65 10
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Ghaemmaghami,
V.
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(2015)
[Drug interactions].
Journal of the Dental School, National University of Iran, 9 1
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•• Important study showing the discrepancy between healthcare professional and patient perception of disease and treatment
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B.
Cusack
(2004)
Pharmacokinetics in older persons.
The American journal of geriatric pharmacotherapy, 2 4
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•• A key document on the awareness and urgency of druig product design related issues and the perspectives of future regulation
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(2016)
Applying human factors and usability engineering to optimize medical device design
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D.
Vetrano,
A.
Calderón-Larrañaga,
A.
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G.
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L.
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L.
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(2017)
An International Perspective on Chronic Multimorbidity: Approaching the Elephant in the Room
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73
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Chih-Wan
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Scientific Reports, 7
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Geriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept
Journal of the American Geriatrics Society, 55
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I.
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J.
Fastbom,
I.
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C.
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Drug—Drug Interactions in the Elderly
Annals of Pharmacotherapy, 36
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• Provide evidence for common trajectories in the multimorbid patient population
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Good practice guide on risk minimisation and prevention of medication errors EMA/606103/2014. Acessed on
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C.
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E.
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Fatimah
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Polypharmacy Among Adults Aged 65 Years and Older in the United States: 1988-2010.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70 8
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R.
Carey,
P.
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(2018)
Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline
Annals of Internal Medicine, 168
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G.
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(2007)
Using a multi-criteria decision making approach to evaluate mobile phone alternatives
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(2006)
Problems with Medication Use in the Elderly: An Australian Perspective
Journal of Pharmacy Practice and Research, 36
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(2012)
Cummulative complexity: a functional, patient-centeredmodel of patient complexity can improve research and practice
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M.
Clerencia-Sierra,
A.
Calderón-Larrañaga,
N.
Martínez-Velilla,
Itziar
Vergara-Mitxeltorena,
Pablo
Aldaz-Herce,
B.
Poblador-Plou,
M.
Machón-Sobrado,
Nerea
Egüés-Olazabal,
Gabor
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A.
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(2015)
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PLoS ONE, 10
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K.
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M.
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A.
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T.
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Clausen
(2004)
Living with advanced heart failure: a prospective, community based study of patients and their carers
European Journal of Heart Failure, 6
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•• Provides clear evidence for the growing challenge of polypharmacy in older people
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B.
Dellhag,
Anders
Bjelle
(1999)
A five-year followup of hand function and activities of daily living in rheumatoid arthritis patients.
Arthritis care and research : the official journal of the Arthritis Health Professions Association, 12 1
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Applying human factors and usability engineering to optimize medical device design. Draft Guidance for industry and Food and Drug Administration Staff. Acessed on
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P.
Reddy,
P.
Martínez-Martín,
Richard
Brown,
K.
Chaudhuri,
Jean-Pierre
Lin,
R.
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I.
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Perceptions of symptoms and expectations of advanced therapy for Parkinson’s disease: preliminary report of a Patient-Reported Outcome tool for Advanced Parkinson’s disease (PRO-APD)
Health and Quality of Life Outcomes, 12
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M.
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N.
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G.
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J.
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D.
Deeg
(2007)
What does quality of life mean to older frail and non-frail
community-dwelling adults in the Netherlands?
Quality of Life Research, 16
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P.
Carayon
(2006)
Handbook of human factors and ergonomics in health care and patient safety
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S.
Stegemann,
J.
Baeyens,
R.
Becker,
M.
Maio,
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F.
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M.
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Design of pharmaceutical products to meet future patient needs requires modification of current development paradigms and business models
Zeitschrift für Gerontologie und Geriatrie, 47
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L.
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L.
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J.
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J.
Williamson,
G.
Anderson
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Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.
The journals of gerontology. Series A, Biological sciences and medical sciences, 59 3
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K.
Notenboom,
E.
Beers,
D.
Riet-Nales,
T.
Egberts,
H.
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P.
Jansen,
M.
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Practical Problems with Medication Use that Older People Experience: A Qualitative Study
Journal of the American Geriatrics Society, 62
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L.
Verbrugge,
Dustin
Brown,
A.
Zajacova
(2017)
Disability Rises Gradually for a Cohort of Older Americans.
The journals of gerontology. Series B, Psychological sciences and social sciences, 72 1
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A.
Stuck,
Jutta
Walthert,
T.
Nikolaus,
C.
Büla,
Christoph
Hohmann,
J.
Beck
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Risk factors for functional status decline in community-living elderly people: a systematic literature review.
Social science & medicine, 48 4
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M.
Schenone,
V.
Dancík,
B.
Wagner,
P.
Clemons
(2013)
Target identification and mechanism of action in chemical biology and drug discovery.
Nature chemical biology, 9 4
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Q8 Pharmaceutical Development Revision 1. Acessed on
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(2018)
Reflection paper on physical frailty: instruments for baseline characterization of older populations in clinical trials
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C.
Auffray,
D.
Charron,
L.
Hood
(2010)
Predictive, preventive, personalized and participatory medicine: back to the future
Genome Medicine, 2
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(2016)
Guidance for Industry
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Siobhan
Dumbreck,
Angela
Flynn,
Moray
Nairn,
Martin
Wilson,
S.
Treweek,
S.
Mercer,
P.
Alderson,
Alex
Thompson,
K.
Payne,
B.
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Drug-disease and drug-drug interactions: systematic examination of recommendations in 12 UK national clinical guidelines
The BMJ, 350
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I.
Kronish,
M.
Woodward,
Z.
Sergie,
G.
Ogedegbe,
L.
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D.
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Meta-Analysis: Impact of Drug Class on Adherence to Antihypertensives
Circulation, 123
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J.
Klahn
(2010)
Principles of universal design
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R.
Kassam,
J.
Collins,
J.
Berkowitz
(2010)
Comparison of Patients' Expectations and Experiences at Traditional Pharmacies and Pharmacies Offering Enhanced Advanced Pharmacy Practice Experiences
American Journal of Pharmaceutical Education, 74
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S.
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An industrial perspective on the design and development of medicines for older patients.
International journal of pharmaceutics, 512 2
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Z.
Marcum,
M.
Pugh,
Megan
Amuan,
Sherrie
Aspinall,
S.
Handler,
C.
Ruby,
J.
Hanlon
(2012)
Prevalence of Potentially Preventable Unplanned Hospitalizations Caused by Therapeutic Failures and Adverse Drug Withdrawal Events Among Older Veterans
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S.
Stegemann
(2016)
The Expectation to Treatment Model: A Framework for Adherence and Effectiveness
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K.
Giacomini,
S.
Yee,
T.
Mushiroda,
R.
Weinshilboum,
M.
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M.
Kubo
(2016)
Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine
Nature Reviews Drug Discovery, 16
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E.
Dolgin
(2014)
Massive schizophrenia genomics study offers new drug directions
Nature Reviews Drug Discovery, 13
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D.
Gelb,
E.
Oliver,
S.
Gilman
(1999)
Diagnostic criteria for Parkinson disease.
Archives of neurology, 56 1
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(1999)
A 5 year followup on hand function and activities of daily living in rheumatoid arthritis patients
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B.
Poblador-Plou,
M.
Akker,
R.
Vos,
A.
Calderón-Larrañaga,
J.
Metsemakers,
A.
Prados-Torres
(2014)
Similar Multimorbidity Patterns in Primary Care Patients from Two European Regions: Results of a Factor Analysis
PLoS ONE, 9
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K.
Turnheim
(2005)
Pharmacokinetic dosage guidelines for elderly subjects
Expert Opinion on Drug Metabolism & Toxicology, 1
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Very good summary of the practical issues and problems with administrating and managing medications in the real world
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C.
Jackson,
Mark
Jones,
L.
Tooth,
G.
Mishra,
J.
Byles,
A.
Dobson
(2015)
Multimorbidity patterns are differentially associated with functional ability and decline in a longitudinal cohort of older women.
Age and ageing, 44 5
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Lydia
Manning,
D.
Carr,
B.
Kail
(2016)
Do Higher Levels of Resilience Buffer the Deleterious Impact of Chronic Illness on Disability in Later Life?
The Gerontologist, 56 3
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•• Excellent review of the consequences of complex medication schedules for older and multimorbid patients
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G.
Trifirò,
E.
Spina
(2011)
Age-related changes in pharmacodynamics: focus on drugs acting on central nervous and cardiovascular systems.
Current drug metabolism, 12 7
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• Real world evidence on the clinical patterns of typical older patient populations and subpopulations
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R.
Messina,
R.
Becker,
D.
Riet-Nales,
S.
Stegemann
(2015)
Results from a preliminary review of scientific evidence for appropriateness of preparations, dosage forms and other product design elements for older adult patients.
International journal of pharmaceutics, 478 2
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(2009)
Very critical findings from the Berlin Aging Study (BASE) related to kidney impairments of older patients recruited between
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F.
Carbone,
L.
Holvoet,
A.
Vandenberghe,
Jan
Tack
(2014)
Functional dyspepsia: outcome of focus groups for the development of a questionnaire for symptom assessment in patients suffering from postprandial distress syndrome (PDS)
Neurogastroenterology & Motility, 26
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(2016)
Use of real-world evidence to support regulatory decision-making for medical devices
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N.
Williams
(2008)
The population bomb
Current Biology, 18
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•• Provides a pragmatic approach towards patient centric drug product design during development
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Luke
Probst,
T.
Welch
(2017)
Pediatric Drug Formulations - Unintended Consequences of Legislation.
The New England journal of medicine, 376 8
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B.
Mukete,
K.
Ferdinand
(2016)
Polypharmacy in Older Adults With Hypertension: A Comprehensive Review
The Journal of Clinical Hypertension, 18
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A.
Corsonello,
C.
Pedone,
R.
Incalzi
(2010)
Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions.
Current medicinal chemistry, 17 6
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(2009)
Pharmaceutical Development. Acessed on September 30, 2017.
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S.
Stenholm,
H.
Westerlund,
J.
Head,
M.
Hyde,
I.
Kawachi,
J.
Pentti,
M.
Kivimäki,
J.
Vahtera
(2014)
Comorbidity and Functional Trajectories From Midlife to Old Age: The Health and Retirement Study
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70
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Reflection Paper: formulations of choice for the pediatric population
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S.
Stegemann
(2016)
Developing Drug Products in an Aging Society
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D.
Riet-Nales,
Karin
Jager,
A.
Schobben,
T.
Egberts,
C.
Rademaker
(2011)
The availability and age-appropriateness of medicines authorized for children in The Netherlands.
British journal of clinical pharmacology, 72 3
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Guideline on the pharmaceutical development of medicines for pediatric use. EMA/CHMP/QWP/805880/2012 Rev. 2. Acessed on
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Provides the evidence for universal design as a way
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Margaret
Landis,
Shobha
Bhattachar,
M.
Yazdanian,
J.
Morrison
(2017)
Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing the Design and Selection of Optimal Drug Candidates
AAPS PharmSciTech, 19
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•• Important contribution to the discussion of drug (non)-adherence with antihypertensive drug treatments
-
M.
Verbrugghe,
S.
Verhaeghe,
Karen
Lauwaert,
D.
Beeckman,
D.
Beeckman,
D.
Beeckman,
A.
Hecke
(2013)
Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review.
Cancer treatment reviews, 39 6
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L.
Fried,
K.
Bandeen-Roche,
J.
Kasper,
J.
Guralnik
(1999)
Association of comorbidity with disability in older women: the Women's Health and Aging Study.
Journal of clinical epidemiology, 52 1
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Nélio
Drumond,
D.
Riet-Nales,
F.
Karapinar‐Çarkit,
S.
Stegemann
(2017)
Patients' appropriateness, acceptability, usability and preferences for pharmaceutical preparations: Results from a literature review on clinical evidence.
International journal of pharmaceutics, 521 1-2
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A.
Prados-Torres,
B.
Poblador-Plou,
A.
Calderón-Larrañaga,
L.
Gimeno-Feliú,
F.
González-Rubio,
Antonio
Poncel-Falcó,
A.
Sicras-Mainar,
J.
Alcalá-Nalvaiz
(2012)
Multimorbidity Patterns in Primary Care: Interactions among Chronic Diseases Using Factor Analysis
PLoS ONE, 7
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Maximilian
König,
M.
Gollasch,
I.
Demuth,
E.
Steinhagen-Thiessen
(2017)
Prevalence of Impaired Kidney Function in the German Elderly: Results from the Berlin Aging Study II (BASE-II)
Gerontology, 63
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M.
Hanson,
C.
Cooper,
A.
Sayer,
R.
Eendebak,
G.
Clough,
J.
Beard
(2016)
Developmental aspects of a life course approach to healthy ageing
The Journal of Physiology, 594
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Matthew
Manary,
William
Boulding,
R.
Staelin,
Seth
Glickman
(2013)
The patient experience and health outcomes.
The New England journal of medicine, 368 3
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J.
Jankovic,
A.
Rajput,
M.
Mcdermott,
D.
Perl
(2000)
The evolution of diagnosis in early Parkinson disease. Parkinson Study Group.
Archives of neurology, 57 3
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M.
Pirmohamed,
Sally
James,
S.
Meakin,
C.
Green,
Andrew
Scott,
Thomas
Walley,
K.
Farrar,
Kevin
Park,
Alasdair
Breckenridge,
J.
Guise,
Marian
McDonagh,
Patricia
Osterweil,
P.
Nygren,
Benjamin
Chan,
M.
Helfand
(2004)
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
BMJ : British Medical Journal, 329
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R.
Shah
(2004)
Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II).
British journal of clinical pharmacology, 58 5
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Guideline on good pharmacovigilance practice (GVP) Module VI: -Management and reporting of adverse reactions to medicinal products (Rev 1)
-
•• Important contribution to the complexity of drug therapy in multimorbid patients
-
• Important study to demonstrate the high degree of medication related issue in older patients and the consequences for patient and society
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•• Important contribution to understand the differences between disability, frailty and co-morbidity
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(2017)
Wearable and miniatirized sensor technologies for personalized and preventive medicine
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M.
Story
(1998)
Maximizing usability: the principles of universal design.
Assistive technology : the official journal of RESNA, 10 1
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David
Lee,
C.
Kawas,
Lisa
Gibbs,
M.
Corrada
(2016)
Prevalence of Frailty and Factors Associated with Frailty in Individuals Aged 90 and Older: The 90+ Study
Journal of the American Geriatrics Society, 64
-
Excellent summary of the urgency for multidisciplinary collaboration to close the knowledge gaps in drug therapy to multimorbid patients
-
(2009)
Q8 Pharmaceutical Development Revision 1. Acessed on September 30, 2017.
-
A.
Mclean,
D.
Couteur
(2004)
Aging Biology and Geriatric Clinical Pharmacology
Pharmacological Reviews, 56
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E.
Gregg,
Arleen
Brown
(2003)
Cognitive and Physical Disabilities and Aging-Related Complications of Diabetes
Clinical Diabetes, 21
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S.
Stegemann,
R.
Ternik,
G.
Onder,
M.
Khan,
D.
Riet-Nales
(2016)
Defining Patient Centric Pharmaceutical Drug Product Design
The AAPS Journal, 18
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S.
Stegemann
(2015)
Drug administration via enteral tubing: an unresolved but increasing challenge
Expert Opinion on Drug Delivery, 12
-
Lawrence
Yu
(2008)
Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control
Pharmaceutical Research, 25
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Universal Design Handbook. 2nd. Chapter 4
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F.
Collins,
M.
Hamburg
(2013)
First FDA authorization for next-generation sequencer.
The New England journal of medicine, 369 25
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E.
Mazzotti,
Claudia
Sebastiani,
P.
Marchetti
(2012)
Patient perception of disease control and psychological distress
Cancer Management and Research, 4
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Pharmaceutical Development. Acessed on
-
V.
Klingmann
(2017)
Acceptability of Mini-Tablets in Young Children: Results from Three Prospective Cross-over Studies
AAPS PharmSciTech, 18
-
Sara
Ahmed,
R.
Berzon,
D.
Revicki,
W.
Lenderking,
C.
Moinpour,
E.
Basch,
B.
Reeve,
A.
Wu
(2012)
The Use of Patient-reported Outcomes (PRO) Within Comparative Effectiveness Research: Implications for Clinical Practice and Health Care Policy
Medical Care, 50
-
Guidance for Industry. Safety considerations for product design to minimize medication errors
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key study to understand the relationship between multimorbidity, age and disabilities
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R.
Goldberg,
J.
Mabee,
Linda
Chan,
Sandra
Wong
(1996)
Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population.
The American journal of emergency medicine, 14 5
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P.
Routledge,
M.
O'Mahony,
K.
Woodhouse
(2003)
Adverse drug reactions in elderly patients.
British journal of clinical pharmacology, 57 2
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Good introduction into the patient perspective of disease perception, therapy acceptance and therapy management strategies
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A.
Zink,
J.
Braun,
J.
Listing,
J.
Wollenhaupt
(2000)
Disability and handicap in rheumatoid arthritis and ankylosing spondylitis--results from the German rheumatological database. German Collaborative Arthritis Centers.
The Journal of rheumatology, 27 3
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J.
Varelius
(2005)
Health and autonomy
Medicine, Health Care and Philosophy, 8
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•• Excellent analysis of the clinically relevant difference in treating younger, older and multimorbid patients
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F.
Cerreta,
J.
Ankri,
D.
Bowen,
A.
Cherubini,
A.
Jentoft,
A.
Guđmundsson,
M.
Haberkamp,
P.
Jansen,
N.
Marchionni,
S.
Morgan,
E.
Rönnemaa,
M.
Petrovic,
A.
Pilotto,
M.
Rosa,
H.
Wildiers
(2016)
Baseline Frailty Evaluation in Drug Development.
The Journal of frailty & aging, 5 3
-
Anna
Beckman,
M.
Parker,
M.
Thorslund
(2005)
Can elderly people take their medicine?
Patient education and counseling, 59 2
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Use of real-world evidence to support regulatory decisionmaking for medical devices. Draft Guidance. Acessed on
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A.
Nobili,
A.
Marengoni,
M.
Tettamanti,
F.
Salerno,
L.
Pasina,
C.
Franchi,
A.
Iorio,
M.
Marcucci,
S.
Corrao,
G.
Licata,
P.
Mannucci
(2011)
Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study.
European journal of internal medicine, 22 6
-
Joanne
Meyer,
G.
Ginsburg
(2002)
The path to personalized medicine.
Current opinion in chemical biology, 6 4
-
A.
Tricoli,
N.
Nasiri,
Sayan
De
(2017)
Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine
Advanced Functional Materials, 27
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E.
Chew,
W.
Ambrosius,
M.
Davis,
R.
Danis,
S.
Gangaputra,
C.
Greven,
L.
Hubbard,
Barbara
Esser,
J.
Lovato,
L.
Perdue,
D.
Goff,
W.
Cushman,
H.
Ginsberg,
M.
Elam,
S.
Genuth,
H.
Gerstein,
U.
Schubart,
Lawrence
Fine
(2010)
Effects of medical therapies on retinopathy progression in type 2 diabetes.
The New England journal of medicine, 363 3