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Increased rates of adverse perinatal outcomes in women with gestational diabetes and depression

Increased rates of adverse perinatal outcomes in women with gestational diabetes and depression Abstract Objective We sought to examine the impact of depression on adverse perinatal outcomes in women with Gestational Diabetes Mellitus (GDM). Methods We performed a retrospective cohort study comparing the rates of perinatal complications among singleton, nonanomalous births to women with GDM and the diagnosis of depression compared to GDM women without depression between 2007 and 2011 in California. Perinatal outcomes were analyzed using chi-square and multivariable logistic regression to compare frequencies of characteristics and outcomes and to determine the strength of association of depression and adverse perinatal outcomes among women with GDM. Statistical comparisons with a p-value of less than .05 and 95% CI that did not cross the null were considered statistically significant. Results Among the cohort of 170,572 women with GDM, 2090 (1.22%) were diagnosed with antenatal depression. Women with GDM and depression had significantly higher rates of preeclampsia (adjusted Odds Ratio [aOR] 1.28, 95% CI 1.11–1.49) and gestational hypertension (aOR 1.23, 95% CI 1.05–1.44). Women with GDM and depression also had higher rates of preterm delivery at <37, and <34 weeks gestational age (aOR 1.33, 95% CI 1.18–1.50 and 1.36, 95% CI 1.15–1.61, respectively). Conclusion Women with GDM and a diagnosis of depression have higher rates of adverse perinatal outcomes than women with GDM alone. Identifying and managing depression among women with GDM has the potential to improve the care and health of this high-risk population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Maternal-Fetal & Neonatal Medicine Taylor & Francis

Increased rates of adverse perinatal outcomes in women with gestational diabetes and depression

Increased rates of adverse perinatal outcomes in women with gestational diabetes and depression

The Journal of Maternal-Fetal & Neonatal Medicine , Volume 34 (23): 5 – Dec 2, 2021

Abstract

Abstract Objective We sought to examine the impact of depression on adverse perinatal outcomes in women with Gestational Diabetes Mellitus (GDM). Methods We performed a retrospective cohort study comparing the rates of perinatal complications among singleton, nonanomalous births to women with GDM and the diagnosis of depression compared to GDM women without depression between 2007 and 2011 in California. Perinatal outcomes were analyzed using chi-square and multivariable logistic regression to compare frequencies of characteristics and outcomes and to determine the strength of association of depression and adverse perinatal outcomes among women with GDM. Statistical comparisons with a p-value of less than .05 and 95% CI that did not cross the null were considered statistically significant. Results Among the cohort of 170,572 women with GDM, 2090 (1.22%) were diagnosed with antenatal depression. Women with GDM and depression had significantly higher rates of preeclampsia (adjusted Odds Ratio [aOR] 1.28, 95% CI 1.11–1.49) and gestational hypertension (aOR 1.23, 95% CI 1.05–1.44). Women with GDM and depression also had higher rates of preterm delivery at <37, and <34 weeks gestational age (aOR 1.33, 95% CI 1.18–1.50 and 1.36, 95% CI 1.15–1.61, respectively). Conclusion Women with GDM and a diagnosis of depression have higher rates of adverse perinatal outcomes than women with GDM alone. Identifying and managing depression among women with GDM has the potential to improve the care and health of this high-risk population.

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References (47)

Publisher
Taylor & Francis
Copyright
© 2019 Informa UK Limited, trading as Taylor & Francis Group
ISSN
1476-4954
eISSN
1476-7058
DOI
10.1080/14767058.2019.1701647
Publisher site
See Article on Publisher Site

Abstract

Abstract Objective We sought to examine the impact of depression on adverse perinatal outcomes in women with Gestational Diabetes Mellitus (GDM). Methods We performed a retrospective cohort study comparing the rates of perinatal complications among singleton, nonanomalous births to women with GDM and the diagnosis of depression compared to GDM women without depression between 2007 and 2011 in California. Perinatal outcomes were analyzed using chi-square and multivariable logistic regression to compare frequencies of characteristics and outcomes and to determine the strength of association of depression and adverse perinatal outcomes among women with GDM. Statistical comparisons with a p-value of less than .05 and 95% CI that did not cross the null were considered statistically significant. Results Among the cohort of 170,572 women with GDM, 2090 (1.22%) were diagnosed with antenatal depression. Women with GDM and depression had significantly higher rates of preeclampsia (adjusted Odds Ratio [aOR] 1.28, 95% CI 1.11–1.49) and gestational hypertension (aOR 1.23, 95% CI 1.05–1.44). Women with GDM and depression also had higher rates of preterm delivery at <37, and <34 weeks gestational age (aOR 1.33, 95% CI 1.18–1.50 and 1.36, 95% CI 1.15–1.61, respectively). Conclusion Women with GDM and a diagnosis of depression have higher rates of adverse perinatal outcomes than women with GDM alone. Identifying and managing depression among women with GDM has the potential to improve the care and health of this high-risk population.

Journal

The Journal of Maternal-Fetal & Neonatal MedicineTaylor & Francis

Published: Dec 2, 2021

Keywords: Gestational diabetes; antenatal depression; adverse perinatal outcomes; preeclampsia; preterm birth

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