A micro-sized model for the in vivo study of nanoparticle toxicity: what has Caenorhabditis elegans taught us?
A micro-sized model for the in vivo study of nanoparticle toxicity: what has Caenorhabditis...
Choi, Jinhee; Tsyusko, Olga V.; Unrine, Jason M.; Chatterjee, Nivedita; Ahn, Jeong-Min; Yang, Xinyu; Thornton, B. Lila; Ryde, Ian T.; Starnes, Daniel; Meyer, Joel N.
2014-06-20 00:00:00
Environmental contextThe ability of the soil nematode Caenorhabditis elegans to withstand a wide range of environmental conditions makes it an idea model for studying the bioavailability and effects of engineered nanomaterials. We critically review what has been learned about the environmental fate of engineered nanoparticles, their effects and their mechanisms of toxicity using this model organism. Future systematic manipulation of nanoparticle properties and environmental variables should elucidate how their interaction influences toxicity and increase the predictive power of nanomaterial toxicity studies.AbstractRecent years have seen a rapid increase in studies of nanoparticle toxicity. These are intended both to reduce the chances of unexpected toxicity to humans or ecosystems, and to inform a predictive framework that would improve the ability to design nanoparticles that are less likely to cause toxicity. Nanotoxicology research has been carried out using a wide range of model systems, including microbes, cells in culture, invertebrates, vertebrates, plants and complex assemblages of species in microcosms and mesocosms. These systems offer different strengths and have also resulted in somewhat different conclusions regarding nanoparticle bioavailability and toxicity. We review the advantages offered by the model organism Caenorhabditis elegans, summarise what has been learned about uptake, distribution and effects of nanoparticles in this organism and compare and contrast these results with those obtained in other organisms, such as daphnids, earthworms, fish and mammalian models.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngEnvironmental ChemistryCSIRO Publishinghttp://www.deepdyve.com/lp/csiro-publishing/a-micro-sized-model-for-the-in-vivo-study-of-nanoparticle-toxicity-yBV2B0xsmb
A micro-sized model for the in vivo study of nanoparticle toxicity: what has Caenorhabditis elegans taught us?
Environmental contextThe ability of the soil nematode Caenorhabditis elegans to withstand a wide range of environmental conditions makes it an idea model for studying the bioavailability and effects of engineered nanomaterials. We critically review what has been learned about the environmental fate of engineered nanoparticles, their effects and their mechanisms of toxicity using this model organism. Future systematic manipulation of nanoparticle properties and environmental variables should elucidate how their interaction influences toxicity and increase the predictive power of nanomaterial toxicity studies.AbstractRecent years have seen a rapid increase in studies of nanoparticle toxicity. These are intended both to reduce the chances of unexpected toxicity to humans or ecosystems, and to inform a predictive framework that would improve the ability to design nanoparticles that are less likely to cause toxicity. Nanotoxicology research has been carried out using a wide range of model systems, including microbes, cells in culture, invertebrates, vertebrates, plants and complex assemblages of species in microcosms and mesocosms. These systems offer different strengths and have also resulted in somewhat different conclusions regarding nanoparticle bioavailability and toxicity. We review the advantages offered by the model organism Caenorhabditis elegans, summarise what has been learned about uptake, distribution and effects of nanoparticles in this organism and compare and contrast these results with those obtained in other organisms, such as daphnids, earthworms, fish and mammalian models.
Journal
Environmental Chemistry
– CSIRO Publishing
Published: Jun 20, 2014
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Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
AshaRani P. V. Mun G. L. K. Hande M. P. Valiyaveettil S.
Oxidative dissolution of silver nanoparticles by biologically relevant oxidants: a kinetic and mechanistic study.
Ho C. M. Yau S. K. Lok C. N. So M. H. Che C. M.
Developmental toxicity in zebrafish ( Danio rerio ) embryos after exposure to manufactured nanomaterials: buckminsterfullerene aggregates ( n C 60 ) and fullerol.
Zhu X. Zhu L. Li Y. Duan Z. Chen W. Alvarez P. J. J.
Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to zebrafish ( Danio rerio ) early developmental stage.
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Cheng J. Flahaut E. Cheng S. H.
In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos.
Lee K. J. Nallathamby P. D. Browning L. M. Osgood C. J. Xu X.-H. N.
In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence.
Pluskota A. Horzowski E. Bossinger O. von Mikecz A.
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Eom H.-J. Choi J.
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Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans .
Kim J. Takahashi M. Shimizu T. Shirasawa T. Kajita M. Kanayama A. Miyamoto Y.
Effects of TAT-conjugated platinum nanoparticles on lifespan of mitochondrial electron transport complex I-deficient Caenorhabditis elegans , nuo-1.
Sakaue Y. Kim J. Miyamoto Y.
Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water-participation of Pt nanoparticles.
Yan H. X. Kinjo T. Tian H. Z. Hamasaki T. Teruya K. Kabayama S. Shirahata S.
Biosafety assessment of titanium dioxide nanoparticles in acutely exposed nematode Caenorhabditis elegans with mutations of genes required for oxidative stress or stress response.
Rui Q. Zhao Y. Wu Q. Tang M. Wang D.
Cerium oxide nanoparticles are more toxic than equimolar bulk cerium oxide in Caenorhabditis elegans .
Arnold M. C. Badireddy A. R. Wiesner M. R. Di Giulio R. T. Meyer J. N.
Aluminum nanoparticle exposure in L1 larvae results in more severe lethality toxicity than in L4 larvae or young adults by strengthening the formation of stress response and intestinal lipofuscin accumulation in nematodes.
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Evaluation of environmental safety concentrations of DMSA coated Fe 2 O 3 -NPs using different assay systems in nematode Caenorhabditis elegans .
Wu Q. Li Y. Tang M. Wang D.
Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans . Journal of applied toxicology.
Hunt P. R. Marquis B. J. Tyner K. M. Conklin S. Olejnik N. Nelson B. C. Sprando R. L.
Probing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryos.
Daniels B. R. Masi B. C. Wirtz D.
Graphite nanoplatelets and Caenorhabditis elegans : insights from an in vivo model.
Zanni E. De Bellis G. Bracciale M. P. Broggi A. Santarelli M. L. Sarto M. S. Palleschi C. Uccelletti D.
Quantum dot nanoparticles affect the reproductive system of Caenorhabditis elegans .
Hsu P.-C. L. O’Callaghan M. Al-Salim N. Hurst M. R. H.
Toxicity of quantum dots and cadmium salt to Caenorhabditis elegans after multigenerational exposure.
Contreras E. Q. Cho M. Zhu H. Puppala H. L. Escalera G. Zhong W. Colvin V. L.
Small sizes of TiO 2 -NPs exhibit adverse effects at predicted environmental relevant concentrations on nematodes in a modified chronic toxicity assay system.
Wu Q. L. Wang W. Li Y. X. Li Y. P. Ye B. P. Tang M. Wang D. Y.
Comparison of toxicities from three metal oxide nanoparticles at environmental relevant concentrations in nematode Caenorhabditis elegans .
Wu Q. L. Nouara A. Li Y. P. Zhang M. Wang W. Tang M. Ye B. P. Ding J. D. Wang D. Y.
The in vivo underlying mechanism for recovery response formation in nano-titanium dioxide exposed Caenorhabditis elegans after transfer to the normal condition.
Zhao Y. Wu Q. Tang M. Wang D.
Molecular control of TiO 2 -NPs toxicity formation at predicted environmental relevant concentrations by Mn-SODs proteins.
Li Y. X. Wang W. Wu Q. L. Li Y. P. Tang M. Ye B. P. Wang D. Y.
Molecular characterization of toxicity mechanism of single-walled carbon nanotubes.
Chen P. H. Hsiao K. M. Chou C. C.
Crucial role of the biological barrier at the primary targeted organs in controlling the translocation and toxicity of multi-walled carbon nanotubes in the nematode Caenorhabditis elegans .
Wu Q. Li Y. Li Y. Zhao Y. Ge L. Wang H. Wang D.
Interfacing multicellular organisms with polyelectrolyte shells and nanoparticles: a Caenorhabtidis elegans study.
Minullina R. T. Osin Y. N. Ishmuchametova D. G. Fakhrullin R. F.
Multigenerational study of gold nanoparticles in Caenorhabditis elegans : transgenerational effect of maternal exposure.
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