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J. Dalenberg, Barkha Patel, R. Denis, M. Veldhuizen, Yuko Nakamura, P. Vinke, S. Luquet, D. Small (2019)
Short-term consumption of sucralose with, but not without, carbohydrate impairs neural and metabolic sensitivity to sugarbioRxiv
Resea R ch h ighlights D ia B ete S n U trit i O n Restoring β-cells Metabolic effects of Dedifferentiation of βcells is thought to be sucralose a major mechanism underlying βcell The effects of consuming low-calorie with carbohydrate, but not without loss and dysfunction in sweeteners such as sucralose are the carbohydrate, resulted in reduced type 1 and type 2 diabe widely debated, with the literature insulin sensitivity. The participants tes mellitus; however, containing conflicting studies. A new also underwent fMRI, which showed whether this process paper suggests that when sucralose that the participants who consumed could be targeted phar is consumed with carbohydrates, sucralose with maltodextrin had The image shows a pancreatic islet from a ma cologically was insulin sensitivity is impaired in reduced responses to sweet taste mouse with streptozotocin-induced diabetes unknown. New research mellitus, with staining for the most frequent cell healthy humans. (but not sour, salty or savoury types in these islets. White stains for the cell nucleus demonstrates that βcell The researchers randomly tastes) in the midbrain, insular (DAPI staining). β-cells (insulin) are stained green, dedifferentiation can assigned 45 healthy volunteers to and cingulate areas of the brain. α-cells (glucagon) are red
Nature Reviews Endocrinology – Springer Journals
Published: May 16, 2020
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