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Magnesium sulfate: a last roll of the dice for anti-excitotoxicity?

Magnesium sulfate: a last roll of the dice for anti-excitotoxicity? www.nature.com/pr COMMENT Magnesium sulfate: a last roll of the dice for anti-excitotoxicity? 1 1 1 Robert Galinsky , Laura Bennet and Alistair J. Gunn Pediatric Research (2019) 86:685–687; https://doi.org/10.1038/s41390-019-0539-9 Therapeutic hypothermia for neonatal encephalopathy (NE) has (MgSO ) in NE suggested that it significantly reduced adverse successfully translated to standard care, confirming the funda- short-term outcomes, with trends for improved long-term out- mental validity of extensive preclinical research across multiple comes but greater mortality. Critically, meta-analysis of large species and settings. The challenge now is to further improve randomized controlled trials of maternal MgSO in preterm labor neuroprotection, so that more babies survive NE without found that it was associated with significantly reduced risk of disability. Current protocols for therapeutic hypothermia appear cerebral palsy (number needed to treat: 64). The pathophysio- 2–4 to be near-optimal, so the obvious solution is to add other logical basis of this association is unclear, and the effects on the neuroprotective agents to hypothermia. Logically, we should primary outcome of death or disability were mixed; a significant follow the example of the development of anticancer drugs and overall effect was seen only in the subset of trials designed to test systematically test different combinations http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Research Springer Journals

Magnesium sulfate: a last roll of the dice for anti-excitotoxicity?

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References (43)

Publisher
Springer Journals
Copyright
Copyright
Subject
Medicine & Public Health; Medicine/Public Health, general; Pediatrics; Pediatric Surgery
ISSN
0031-3998
eISSN
1530-0447
DOI
10.1038/s41390-019-0539-9
Publisher site
See Article on Publisher Site

Abstract

www.nature.com/pr COMMENT Magnesium sulfate: a last roll of the dice for anti-excitotoxicity? 1 1 1 Robert Galinsky , Laura Bennet and Alistair J. Gunn Pediatric Research (2019) 86:685–687; https://doi.org/10.1038/s41390-019-0539-9 Therapeutic hypothermia for neonatal encephalopathy (NE) has (MgSO ) in NE suggested that it significantly reduced adverse successfully translated to standard care, confirming the funda- short-term outcomes, with trends for improved long-term out- mental validity of extensive preclinical research across multiple comes but greater mortality. Critically, meta-analysis of large species and settings. The challenge now is to further improve randomized controlled trials of maternal MgSO in preterm labor neuroprotection, so that more babies survive NE without found that it was associated with significantly reduced risk of disability. Current protocols for therapeutic hypothermia appear cerebral palsy (number needed to treat: 64). The pathophysio- 2–4 to be near-optimal, so the obvious solution is to add other logical basis of this association is unclear, and the effects on the neuroprotective agents to hypothermia. Logically, we should primary outcome of death or disability were mixed; a significant follow the example of the development of anticancer drugs and overall effect was seen only in the subset of trials designed to test systematically test different combinations

Journal

Pediatric Research – Springer Journals

Published: Aug 14, 2019

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