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Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers.

Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers. A Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Organic Letters Pubmed

Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers.

Organic Letters , Volume 21 (8): 5 – Jun 13, 2019

Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers.


Abstract

A Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

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ISSN
1523-7060
DOI
10.1021/acs.orglett.9b01016
pmid
30924663

Abstract

A Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

Journal

Organic LettersPubmed

Published: Jun 13, 2019

References