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Bioactive Sesquiterpene Lactones Isolated from the Whole Plants of Vernonia cinerea.

Bioactive Sesquiterpene Lactones Isolated from the Whole Plants of Vernonia cinerea. Twelve sesquiterpene lactones were isolated from the whole plants of Vernonia cinerea. These included eight new compounds, vercinolides A-H (1-8), along with four known substances (9-12). The structures of the new compounds were determined by 1D and 2D NMR experiments and mass spectrometric methods. The absolute configurations of compounds 1-8 were determined by Mosher experiments and ECD data. Compounds 1-8 are the first examples of a new class of sesquiterpene lactones possessing a rare 4α,10α-ether ring and a 2,14-ether ring. Compounds 1-4, 6, 8, 10, and 12 were evaluated for their cytotoxic and anti-inflammatory activities. Compounds 10 and 12 exhibited inhibitory effects against nitric oxide production in lipopolysaccharide-activated RAW 264.7 mouse macrophage cells with IC50 values of 21 and 23 μM, respectively. Both compounds were inactive for HeLa cells (IC50 > 10 μM). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Natural Products Pubmed

Bioactive Sesquiterpene Lactones Isolated from the Whole Plants of Vernonia cinerea.

Journal of Natural Products , Volume 82 (8): 8 – Oct 21, 2020

Bioactive Sesquiterpene Lactones Isolated from the Whole Plants of Vernonia cinerea.


Abstract

Twelve sesquiterpene lactones were isolated from the whole plants of Vernonia cinerea. These included eight new compounds, vercinolides A-H (1-8), along with four known substances (9-12). The structures of the new compounds were determined by 1D and 2D NMR experiments and mass spectrometric methods. The absolute configurations of compounds 1-8 were determined by Mosher experiments and ECD data. Compounds 1-8 are the first examples of a new class of sesquiterpene lactones possessing a rare 4α,10α-ether ring and a 2,14-ether ring. Compounds 1-4, 6, 8, 10, and 12 were evaluated for their cytotoxic and anti-inflammatory activities. Compounds 10 and 12 exhibited inhibitory effects against nitric oxide production in lipopolysaccharide-activated RAW 264.7 mouse macrophage cells with IC50 values of 21 and 23 μM, respectively. Both compounds were inactive for HeLa cells (IC50 > 10 μM).

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ISSN
0163-3864
eISSN
1520-6025
DOI
10.1021/acs.jnatprod.8b01078
pmid
31411887

Abstract

Twelve sesquiterpene lactones were isolated from the whole plants of Vernonia cinerea. These included eight new compounds, vercinolides A-H (1-8), along with four known substances (9-12). The structures of the new compounds were determined by 1D and 2D NMR experiments and mass spectrometric methods. The absolute configurations of compounds 1-8 were determined by Mosher experiments and ECD data. Compounds 1-8 are the first examples of a new class of sesquiterpene lactones possessing a rare 4α,10α-ether ring and a 2,14-ether ring. Compounds 1-4, 6, 8, 10, and 12 were evaluated for their cytotoxic and anti-inflammatory activities. Compounds 10 and 12 exhibited inhibitory effects against nitric oxide production in lipopolysaccharide-activated RAW 264.7 mouse macrophage cells with IC50 values of 21 and 23 μM, respectively. Both compounds were inactive for HeLa cells (IC50 > 10 μM).

Journal

Journal of Natural ProductsPubmed

Published: Oct 21, 2020

There are no references for this article.