S. Bilginer, Baris Gonder, H. Gul, Ruya Kaya, I. Gulcin, B. Anıl, C. Supuran (2019)
Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory propertiesJournal of Enzyme Inhibition and Medicinal Chemistry, 35
Hany Ibrahim, Heba Allam, Walaa Mahmoud, Alessandro Bonardi, A. Nocentini, P. Gratteri, E. Ibrahim, H. Abdel‐Aziz, C. Supuran (2018)
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.European journal of medicinal chemistry, 152
M. Şentürk, I. Gülçin, A. Daştan, O. Küfrevioğlu, C. Supuran (2009)
Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.Bioorganic & medicinal chemistry, 17 8
Ş. Akın, Hasan Ayaloglu, Ergun Gultekin, A. Colak, O. Bekircan, M. Akatin (2019)
Synthesis of 1,2,4-triazole-5-on derivatives and determination of carbonic anhydrase II isoenzyme inhibition effects.Bioorganic chemistry, 83
Juan Sun, Ming-hui Li, S. Qian, F. Guo, Xiaofang Dang, Xiao-Ming Wang, Ya-Rong Xue, Hailiang Zhu (2013)
Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors.Bioorganic & medicinal chemistry letters, 23 10
Lalit Vats, R. Kumar, Silvia Bua, A. Nocentini, P. Gratteri, C. Supuran, P. Sharma (2019)
Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, 183
C. Supuran (2016)
How many carbonic anhydrase inhibition mechanisms exist?Journal of Enzyme Inhibition and Medicinal Chemistry, 31
S. Valente, D. Trisciuoglio, T. Luca, A. Nebbioso, D. Labella, Alessia Lenoci, C. Bigogno, G. Dondio, M. Miceli, G. Brosch, D. Bufalo, L. Altucci, A. Mai (2014)
1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.Journal of medicinal chemistry, 57 14
Betul Arabaci, I. Gulcin, S. Alwasel (2014)
Capsaicin: A Potent Inhibitor of Carbonic Anhydrase IsoenzymesMolecules, 19
Suleyman Akocak, C. Supuran (2019)
Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a reviewJournal of Enzyme Inhibition and Medicinal Chemistry, 34
H. Gul, M. Tuğrak, M. Gul, Sertac Mazlumoglu, H. Sakagami, I. Gulcin, C. Supuran (2019)
New phenolic Mannich bases with piperazines and their bioactivities.Bioorganic chemistry, 90
C. Supuran (2008)
Carbonic anhydrases: novel therapeutic applications for inhibitors and activatorsNature Reviews Drug Discovery, 7
Cd. Morris, A. Rose, J. Curwen, A. Hughes, D. Wilson, D. Webb (2005)
Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidenceBritish Journal of Cancer, 92
C. Supuran (2012)
Structure-based drug discovery of carbonic anhydrase inhibitorsJournal of Enzyme Inhibition and Medicinal Chemistry, 27
Xiaoke Guo, Xianglei Ma, Qian Yang, Jing Xu, Lu Huang, Jianmin Jia, Jiaojiao Shan, Li Liu, Weilin Chen, Hongxi Chu, Jinlian Wei, Xiaojin Zhang, Haopeng Sun, Yiqun Tang, Q. You (2014)
Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).European journal of medicinal chemistry, 81
Vikas Sharma, R. Kumar, Silvia Bua, C. Supuran, P. Sharma (2019)
Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors.Bioorganic chemistry, 85
Akın Akıncıoğlu, Hulya Akıncıoğlu, I. Gülçin, S. Durdağı, C. Supuran, S. Göksu (2015)
Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.Bioorganic & medicinal chemistry, 23 13
(2008)
Carbonic anhydrases an overview
S. Bilginer, H. Gul, F. Erdal, H. Sakagami, Serkan Levent, I. Gulcin, C. Supuran (2019)
Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolonesJournal of Enzyme Inhibition and Medicinal Chemistry, 34
C. Supuran (2016)
Structure and function of carbonic anhydrases.The Biochemical journal, 473 14
Lalit Vats, Vikas Sharma, A. Angeli, R. Kumar, C. Supuran, P. Sharma (2018)
Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, 150
W. Caneschi, K. Enes, Camille Mendonça, Fábio Fernandes, F. Miguel, Jefferson Martins, M. Hyaric, R. Pinho, L. Duarte, Marcone Oliveira, H. Santos, M. Lopes, Dalton Dittz, H. Silva, Mara Couri (2019)
Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles.European journal of medicinal chemistry, 165
R. Kumar, Silvia Bua, Sita Ram, S. Prete, C. Capasso, C. Supuran, P. Sharma (2017)
Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry, 25 3
R. Kumar, Vikas Sharma, Silvia Bua, C. Supuran, P. Sharma (2017)
Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activityJournal of Enzyme Inhibition and Medicinal Chemistry, 32
A. Banerjee, N. Das, S. Shengule, R. Srivastava, S. Shrivastava (2015)
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.European journal of medicinal chemistry, 101
Poonam Khloya, Gulsah Celik, Sitaram, D. Vullo, C. Supuran, P. Sharma (2014)
4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII.European journal of medicinal chemistry, 76
Wenneng Wu, Qin Chen, A. Tai, Guang-Cheng Jiang, Gui-ping Ouyang (2015)
Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives.Bioorganic & medicinal chemistry letters, 25 10
M. Tuğrak, H. Gul, K. Bandow, H. Sakagami, I. Gulcin, Yusuf Ozkay, C. Supuran (2019)
Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors.Bioorganic chemistry, 90
D. Dewangan, K. Nakhate, D. Tripathi, P. Kashyap, H. Dhongde (2015)
Synthesis, Characterization and Screening for Analgesic and Anti-inflammatory activities of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives.Anti-inflammatory & anti-allergy agents in medicinal chemistry, 14 2
C. Supuran, J. Winum (2015)
Carbonic anhydrase IX inhibitors in cancer therapy: an update.Future medicinal chemistry, 7 11
G. Klose, E. Ludwig, E. Uhlemann (1977)
N.m.r. studies of the keto–enol tautomerism of acylthioacetamidesMagnetic Resonance in Chemistry, 10
A. Yıldırım, Ufuk Atmaca, A. Keskin, M. Topal, Murat Çelik, I. Gülçin, C. Supuran (2015)
N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II.Bioorganic & medicinal chemistry, 23 10
M. Boztaş, Yasin Çetinkaya, M. Topal, I. Gülçin, A. Menzek, E. Şahin, Muhammet Tanc, C. Supuran (2015)
Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.Journal of medicinal chemistry, 58 2
Muhammet Tanc, F. Carta, A. Scozzafava, C. Supuran (2015)
6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA.Organic & biomolecular chemistry, 13 1
D. Chi, L. Shahrik, H. Ho, E. Hamel (1989)
Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines.Cancer research, 49 6
Niccolò Chiaramonte, Silvia Bua, A. Angeli, M. Ferraroni, Ilaria Picchioni, G. Bartolucci, Laura Braconi, S. Dei, E. Teodori, C. Supuran, M. Romanelli (2019)
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors.Bioorganic chemistry, 91
A. Angeli, M. Ferraroni, C. Supuran (2018)
Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.ACS medicinal chemistry letters, 9 10
D. Neri, C. Supuran (2011)
Interfering with pH regulation in tumours as a therapeutic strategyNature Reviews Drug Discovery, 10
A. Nocentini, Elena Trallori, Srishti Singh, C. Lomelino, G. Bartolucci, L. Mannelli, C. Ghelardini, R. McKenna, P. Gratteri, C. Supuran (2018)
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.Journal of medicinal chemistry, 61 23
K. Manjunatha, B. Poojary, P. Lobo, Jennifer Fernandes, N. Kumari (2010)
Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives.European journal of medicinal chemistry, 45 11
R. Kumar, Lalit Vats, Silvia Bua, C. Supuran, P. Sharma (2018)
Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors.European journal of medicinal chemistry, 155
S. Sarıkaya, I. Gülçin, C. Supuran (2010)
Carbonic Anhydrase Inhibitors: Inhibition of Human Erythrocyte Isozymes I and II with a Series of Phenolic AcidsChemical Biology & Drug Design, 75
Heba Allam, Samar Fahim, Mahmoud F.Abo-Ashour, A. Nocentini, Mohamed Elbakry, Mohamed Abdelrahman, Wagdy Eldehna, Hany Ibrahim, C. Supuran (2019)
Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.European journal of medicinal chemistry, 179
B. Kurt, Aydan Dağ, Berna Dogan, S. Durdağı, A. Angeli, A. Nocentini, C. Supuran, F. Sonmez (2019)
Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma.Bioorganic chemistry, 87
S. Shahzad, M. Yar, M. Bajda, B. Jadoon, Z. Khan, S. Naqvi, A. Shaikh, K. Hayat, A. Mahmmod, N. Mahmood, S. Filipek (2014)
Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents.Bioorganic & medicinal chemistry, 22 3
R. Khalifah (1971)
The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.The Journal of biological chemistry, 246 8
V. Alterio, A. Fiore, K. D'Ambrosio, C. Supuran, G. Simone (2012)
Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?Chemical reviews, 112 8
C. Wykoff, N. Beasley, P. Watson, K. Turner, J. Pastorek, A. Sibtain, G. Wilson, H. Turley, K. Talks, P. Maxwell, C. Pugh, P. Ratcliffe, A. Harris (2000)
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.Cancer research, 60 24
European Journal of Medicinal Chemistry – Pubmed
Published: Nov 30, 2020
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