Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Boon, G. Mutsert, D. Baarle, Derek Smith, A. Lapedes, R. Fouchier, K. Sintnicolaas, A. Osterhaus, G. Rimmelzwaan (2004)
Recognition of Homo- and Heterosubtypic Variants of Influenza A Viruses by Human CD8+ T Lymphocytes1The Journal of Immunology, 172
Matthew Memoli, P. Shaw, A. Han, Lindsay Czajkowski, Susan Reed, Rani Athota, T. Bristol, Sarah Fargis, Kyle Risos, J. Powers, R. Davey, J. Taubenberger (2016)
Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge ModelmBio, 7
R. Couch, R. Atmar, Luis Franco, J. Quarles, Janet Wells, N. Arden, D. Niño, J. Belmont (2013)
Antibody correlates and predictors of immunity to naturally occurring influenza in humans and the importance of antibody to the neuraminidase.The Journal of infectious diseases, 207 6
A. McMichael, D. Dongworth, F. Gotch, A. Clark, C. Potter (1983)
DECLINING T-CELL IMMUNITY TO INFLUENZA, 1977-82The Lancet, 322
M. Pilkinton, Katherine Nicholas, Christian Warren, Rita Smith, S. Yoder, H. Talbot, Spyros Kalams, Spyros Kalams (2017)
Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion.Vaccine, 35 2
Karlynn Neu, Carole Dunand, P. Wilson (2016)
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?Current opinion in immunology, 42
S. Sridhar, S. Begom, A. Bermingham, K. Hoschler, W. Adamson, W. Carman, T. Bean, W. Barclay, J. Deeks, A. Lalvani (2013)
Cellular immune correlates of protection against symptomatic pandemic influenzaNature Medicine, 19
A. Monto, A. Kendal (1973)
Effect of neuraminidase antibody on Hong Kong influenza.Lancet, 1 7804
T. Wilkinson, C. Li, Cecilia Chui, A. Huang, Molly Perkins, Julia Liebner, Rob Lambkin-Williams, A. Gilbert, J. Oxford, Ben Nicholas, K. Staples, T. Dong, D. Douek, A. McMichael, Xiao-ning Xu (2012)
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humansNature Medicine, 18
K. Flynn, G. Belz, J. Altman, R. Ahmed, D. Woodland, P. Doherty (1998)
Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.Immunity, 8 6
R. Purwar, J. Campbell, G. Murphy, W. Richards, R. Clark, T. Kupper (2011)
Resident Memory T Cells (TRM) Are Abundant in Human Lung: Diversity, Function, and Antigen SpecificityPLoS ONE, 6
F. Krammer, Natalie Pica, R. Hai, Irina Margine, P. Palese (2013)
Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific AntibodiesJournal of Virology, 87
S. Basha, Staci Hazenfeld, R. Brady, R. Subbramanian (2011)
Comparison of antibody and T-cell responses elicited by licensed inactivated- and live-attenuated influenza vaccines against H3N2 hemagglutinin.Human immunology, 72 6
Aitor Nogales, Steven Baker, William Domm, L. Martínez-Sobrido (2016)
Development and applications of single-cycle infectious influenza A virus (sciIAV).Virus research, 216
M. Clements, R. Betts, E. Tierney, B. Murphy (1986)
Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virusJournal of Clinical Microbiology, 24
L. Fries, Gale Smith, G. Glenn (2013)
A recombinant viruslike particle influenza A (H7N9) vaccine.The New England journal of medicine, 369 26
Laura Gillim-Ross, Celia Santos, Zhongying Chen, Amy Aspelund, Chin-fen Yang, D. Ye, H. Jin, G. Kemble, K. Subbarao (2008)
Avian Influenza H6 Viruses Productively Infect and Cause Illness in Mice and FerretsJournal of Virology, 82
L. Grohskopf, L. Sokolow, A. Fry, E. Walter, D. Jernigan (2018)
Update: ACIP Recommendations for the Use of Quadrivalent Live Attenuated Influenza Vaccine (LAIV4) — United States, 2018–19 Influenza SeasonMorbidity and Mortality Weekly Report, 67
ED Kilbourne, CP Cerini, MW Khan, JWJ Mitchell, PL Ogra (1987)
Immunologic response to the influenza virus neuraminidase is influenced by prior experience with the associated viral heamgglutininJ Immunol., 138
Taia Wang, Jad Maamary, G. Tan, S. Bournazos, C. Davis, F. Krammer, S. Schlesinger, P. Palese, R. Ahmed, J. Ravetch (2015)
Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine EfficacyCell, 162
S. Bentebibel, S. Lopez, G. Obermoser, N. Schmitt, C. Mueller, C. Harrod, E. Flaño, A. Mejías, R. Albrecht, D. Blankenship, Hui Xu, V. Pascual, J. Banchereau, A. García-Sastre, A. Palucka, O. Ramilo, H. Ueno (2013)
Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza VaccinationScience Translational Medicine, 5
F. Ansaldi, S. Bacilieri, P. Durando, L. Sticchi, L. Valle, E. Montomoli, G. Icardi, R. Gasparini, P. Crovari (2008)
Cross-protection by MF59-adjuvanted influenza vaccine: neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses.Vaccine, 26 12
J. Atsmon, Y. Caraco, Sagit Ziv-Sefer, Dimitry Shaikevich, Ester Abramov, I. Volokhov, Svetlana Bruzil, Kirsten Haima, T. Gottlieb, T. Ben-Yedidia (2014)
Priming by a novel universal influenza vaccine (Multimeric-001)-a gateway for improving immune response in the elderly population.Vaccine, 32 44
J. Kim, Justine Liepkalns, A. Reber, Xiuhua Lu, Nedzad Music, Joshy Jacob, S. Sambhara (2016)
Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains.Vaccine, 34 4
K. Zens, Jun Chen, D. Farber (2016)
Vaccine-generated lung tissue-resident memory T cells provide heterosubtypic protection to influenza infection.JCI insight, 1 10
G. Lombardi, C. Casalone, Antonio Angelo, D. Gelmetti, G. Torcoli, I. Barbieri, C. Corona, E. Fasoli, A. Farinazzo, M. Fiorini, M. Gelati, B. Iulini, F. Tagliavini, S. Ferrari, M. Caramelli, S. Monaco, L. Capucci, G. Zanusso (2008)
Intraspecies Transmission of BASE Induces Clinical Dullness and Amyotrophic ChangesPLoS Pathogens, 4
R. Couch, R. Douglas, D. Fedson, J. Kasel (1971)
Correlated studies of a recombinant influenza-virus vaccine. 3. Protection against experimental influenza in man.The Journal of infectious diseases, 124 5
R. Herati, A. Muselman, L. Vella, L. Vella, B. Bengsch, Kaela Parkhouse, Daniel Alcazar, Jonathan Kotzin, Susan Doyle, P. Tebas, S. Hensley, S. Hensley, L. Su, K. Schmader, E. Wherry (2017)
Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cellsScience Immunology, 2
V. Mallajosyula, M. Citron, F. Ferrara, Nigel Temperton, Xiao-ping Liang, Jessica Flynn, R. Varadarajan (2015)
Hemagglutinin Sequence Conservation Guided Stem Immunogen Design from Influenza A H3 SubtypeFrontiers in Immunology, 6
H. Yassine, J. Boyington, P. McTamney, Chih-Jen Wei, M. Kanekiyo, W. Kong, J. Gallagher, Lingshu Wang, Yi Zhang, M. Joyce, D. Lingwood, Syed Moin, H. Andersen, Y. Okuno, Srinivas Rao, Audray Harris, P. Kwong, J. Mascola, G. Nabel, B. Graham (2015)
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protectionNature Medicine, 21
Zhongying Chen, Celia Santos, Amy Aspelund, Laura Gillim-Ross, H. Jin, G. Kemble, K. Subbarao (2008)
Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and FerretsJournal of Virology, 83
B. Holzer, S. Morgan, Y. Matsuoka, M. Edmans, F. Salguero, H. Everett, S. Brookes, Emily Porter, R. Macloughlin, B. Charleston, K. Subbarao, Alain Townsend, E. Tchilian (2018)
Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza VaccineThe Journal of Immunology Author Choice, 200
Sinthujan Jegaskanda, R. Mason, Sarah Andrews, A. Wheatley, Ruijun Zhang, Glennys Reynoso, D. Ambrozak, Celia Santos, C. Luke, Y. Matsuoka, J. Brenchley, H. Hickman, K. Talaat, S. Permar, H. Liao, J. Yewdell, R. Koup, M. Roederer, A. McDermott, K. Subbarao (2018)
Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph NodesJournal of Virology, 92
E. Miller, N. Andrews, L. Stellitano, J. Stowe, A. Winstone, J. Shneerson, C. Verity (2013)
Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysisBMJ : British Medical Journal, 346
K. Yap, G. Ada (1978)
The Recovery of Mice from Influenza A Virus Infection: Adoptive Transfer of Immunity with Influenza Virus‐specific Cytotoxic T Lymphocytes Recognizing a Common Virion AntigenScandinavian Journal of Immunology, 8
D. Acharya, Penghua Wang, Amber Paul, Jianfeng Dai, D. Gate, Jordan Lowery, D. Stokic, A. Leis, R. Flavell, T. Town, E. Fikrig, F. Bai (2016)
Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus ClearanceJournal of Virology, 91
Glendie Marcelin, R. DuBois, Adam Rubrum, C. Russell, J. Mcelhaney, R. Webby (2011)
A Contributing Role for Anti-Neuraminidase Antibodies on Immunity to Pandemic H1N1 2009 Influenza A VirusPLoS ONE, 6
C. Gianfrani, C. Oseroff, J. Sidney, R. Chesnut, A. Sette (2000)
Human memory CTL response specific for influenza A virus is broad and multispecific.Human immunology, 61 5
Yasuko Hatta, D. Boltz, S. Sarawar, Y. Kawaoka, G. Neumann, P. Bilsel (2017)
M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza.Vaccine, 35 33
J. Seto, Flora Chang (1969)
Functional Significance of Sialidase During Influenza Virus Multiplication: an Electron Microscope StudyJournal of Virology, 4
A. Monto, J. Petrie, Rachel Cross, Emileigh Johnson, Merry Liu, W. Zhong, M. Levine, J. Katz, S. Ohmit (2015)
Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection.The Journal of infectious diseases, 212 8
B. Chua, David Pejoski, S. Turner, W. Zeng, D. Jackson (2011)
Soluble Proteins Induce Strong CD8+ T Cell and Antibody Responses through Electrostatic Association with Simple Cationic or Anionic Lipopeptides That Target TLR2The Journal of Immunology, 187
A. Tricco, A. Chit, C. Soobiah, D. Hallett, G. Meier, M. Chen, M. Tashkandi, C. Bauch, M. Loeb (2013)
Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysisBMC Medicine, 11
K. Talaat, C. Luke, S. Khurana, J. Manischewitz, L. King, Bridget McMahon, R. Karron, Kristen Lewis, Jing Qin, D. Follmann, H. Golding, K. Neuzil, K. Subbarao (2014)
A live attenuated influenza A(H5N1) vaccine induces long-term immunity in the absence of a primary antibody response.The Journal of infectious diseases, 209 12
T. Gebhardt, L. Wakim, L. Eidsmo, P. Reading, W. Heath, F. Carbone (2009)
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virusNature Immunology, 10
F. Geeraedts, N. Goutagny, V. Hornung, M. Severa, A. Haan, Judith Pool, J. Wilschut, K. Fitzgerald, A. Huckriede (2008)
Superior Immunogenicity of Inactivated Whole Virus H5N1 Influenza Vaccine is Primarily Controlled by Toll-like Receptor SignallingPLoS Pathogens, 4
J. Wiley, A. Cerwenka, Jack Harkema, R. Dutton, Allen Harmsen (2001)
Production of interferon-gamma by influenza hemagglutinin-specific CD8 effector T cells influences the development of pulmonary immunopathology.The American journal of pathology, 158 1
T. Ebels, J. Heide (1977)
DOPAMINE-INDUCED ISCHEMIAThe Lancet, 310
E. Grant, Li Chen, S. Quiñones-Parra, K. Pang, K. Kedzierska, Weisan Chen (2014)
T-cell immunity to influenza A viruses.Critical reviews in immunology, 34 1
Mark Steinhoff, Louis Fries, R. Karron, M. Clements, Brian Murphy (1993)
Effect of heterosubtypic immunity on infection with attenuated influenza A virus vaccines in young childrenJournal of Clinical Microbiology, 31
R. Clover, S. Crawford, W. Glezen, L. Taber, Matson Cc, R. Couch (1991)
Comparison of heterotypic protection against influenza A/Taiwan/86 (H1N1) by attenuated and inactivated vaccines to A/Chile/83-like viruses.The Journal of infectious diseases, 163 2
K. Florek, J. Weinfurter, Sinthujan Jegaskanda, Joseph Brewoo, T. Powell, Ginger Young, Subash Das, M. Hatta, K. Broman, O. Hungnes, S. Dudman, Y. Kawaoka, S. Kent, D. Stinchcomb, J. Osorio, T. Friedrich (2014)
Modified Vaccinia Virus Ankara Encoding Influenza Virus Hemagglutinin Induces Heterosubtypic Immunity in MacaquesJournal of Virology, 88
K. Talaat, R. Karron, Karen Callahan, C. Luke, Susan Dilorenzo, Grace Chen, E. Lamirande, H. Jin, K. Coelingh, B. Murphy, G. Kemble, K. Subbarao (2009)
A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults.Vaccine, 27 28
E. Grant, Chao Wu, K. Chan, S. Eckle, M. Bharadwaj, Q. Zou, K. Kedzierska, Weisan Chen (2013)
Nucleoprotein of influenza A virus is a major target of immunodominant CD8+ T‐cell responsesImmunology and Cell Biology, 91
S. Rockman, L. Brown, I. Barr, B. Gilbertson, S. Lowther, A. Kachurin, O. Kachurina, J. Klippel, J. Bodle, M. Pearse, D. Middleton (2013)
Neuraminidase-Inhibiting Antibody Is a Correlate of Cross-Protection against Lethal H5N1 Influenza Virus in Ferrets Immunized with Seasonal Influenza VaccineJournal of Virology, 87
T. Vesikari, N. Groth, A. Karvonen, A. Borkowski, M. Pellegrini (2009)
MF59-adjuvanted influenza vaccine (FLUAD) in children: safety and immunogenicity following a second year seasonal vaccination.Vaccine, 27 45
T. Sutton, E. Lamirande, Rita Czakó, K. Subbarao (2017)
Evaluation of the Biological Properties and Cross-Reactive Antibody Response to H10 Influenza Viruses in FerretsJournal of Virology, 91
Jason Oh, Rajesh Ravindran, B. Chassaing, F. Carvalho, F. Carvalho, M. Maddur, Maureen Bower, Paul Hakimpour, K. Gill, H. Nakaya, H. Nakaya, F. Yarovinsky, R. Sartor, A. Gewirtz, B. Pulendran (2014)
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.Immunity, 41 3
Xiaosong He, T. Holmes, Caiqiu Zhang, K. Mahmood, G. Kemble, D. Lewis, C. Dekker, H. Greenberg, A. Arvin (2006)
Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza VaccinesJournal of Virology, 80
V. Mallajosyula, M. Citron, F. Ferrara, Xianghan Lu, Cheryl Callahan, G. Heidecker, S. Sarma, Jessica Flynn, Nigel Temperton, X. Liang, R. Varadarajan (2014)
Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protectionProceedings of the National Academy of Sciences, 111
K. Klonowski, K. Williams, A. Marzo, D. Blair, E. Lingenheld, L. Lefrançois (2004)
Dynamics of blood-borne CD8 memory T cell migration in vivo.Immunity, 20 5
B. Johansson, E. Kilbourne (1993)
Dissociation of influenza virus hemagglutinin and neuraminidase eliminates their intravirionic antigenic competitionJournal of Virology, 67
G. Lowell, Sagit Ziv, Svetlana Bruzil, Ron Babecoff, T. Ben-Yedidia (2017)
Back to the future: Immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain.Vaccine, 35 5
E. Kilbourne, C. Cerini, M. Khan, J. Mitchell, P. Ogra (1987)
Immunologic response to the influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin. I. Studies in human vaccinees.Journal of immunology, 138 9
Li Chen, D. Zanker, Kun Xiao, Chao Wu, Q. Zou, Weisan Chen (2014)
Immunodominant CD4+ T-Cell Responses to Influenza A Virus in Healthy Individuals Focus on Matrix 1 and NucleoproteinJournal of Virology, 88
J. Min, Leatrice Vogel, Y. Matsuoka, Bin Lu, D. Swayne, H. Jin, G. Kemble, K. Subbarao (2010)
A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and MonkeysJournal of Virology, 84
P. Izurieta, W. Kim, S. Wie, Jacob Lee, Jin-Soo Lee, M. Drame, D. Vaughn, A. Schuind (2015)
Immunogenicity and safety of an AS03-adjuvanted H5N1 pandemic influenza vaccine in Korean adults: a phase IV, randomized, open-label, controlled study.Vaccine, 33 24
R. Belshe, Min-Shi Lee, R. Walker, J. Stoddard, P. Mendelman (2004)
Safety, immunogenicity and efficacy of intranasal, live attenuated influenza vaccineExpert Review of Vaccines, 3
H. Katsura, K. Iwatsuki-Horimoto, S. Fukuyama, Shinji Watanabe, Saori Sakabe, Yasuko Hatta, S. Murakami, M. Shimojima, T. Horimoto, Y. Kawaoka (2012)
A replication-incompetent virus possessing an uncleavable hemagglutinin as an influenza vaccine.Vaccine, 30 42
D. Topham, P. Doherty (1998)
Clearance of an Influenza A Virus by CD4+ T Cells Is Inefficient in the Absence of B CellsJournal of Virology, 72
Longlong Si, Huan Xu, Xueying Zhou, Ziwei Zhang, Zhenyu Tian, Yan Wang, Yiming Wu, Bo Zhang, Z. Niu, Chuanling Zhang, Ge Fu, S. Xiao, Qing Xia, Lihe Zhang, Demin Zhou (2016)
Generation of influenza A viruses as live but replication-incompetent virus vaccinesScience, 354
C. Mclaren, Christopher Potter (1973)
Immunity to influenza in ferretsMedical Microbiology and Immunology, 159
L. Wakim, T. Gebhardt, W. Heath, F. Carbone (2008)
Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid TissuesThe Journal of Immunology, 181
R. Antrobus, T. Berthoud, Caitlin Mullarkey, K. Hoschler, Lynda Coughlan, M. Zambon, A. Hill, S. Gilbert (2014)
Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses.Molecular therapy : the journal of the American Society of Gene Therapy, 22 1
K. McKinstry, T. Strutt, Y. Kuang, Deborah Brown, S. Sell, R. Dutton, S. Swain (2012)
Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms.The Journal of clinical investigation, 122 8
H. Bui, Bjoern Peters, E. Assarsson, I. Mbawuike, A. Sette (2007)
Ab and T cell epitopes of influenza A virus, knowledge and opportunitiesProceedings of the National Academy of Sciences, 104
K. Beutner, T. Chow, E. Rubi, J. Strussenberg, J. Clement, P. Ogra (1979)
Evaluation of a neuraminidase-specific influenza A virus vaccine in children: antibody responses and effects on two successive outbreaks of natural infection.The Journal of infectious diseases, 140 6
A. Impagliazzo, F. Milder, H. Kuipers, M. Wagner, Xueyong Zhu, Ryan Hoffman, Ruud Meersbergen, Jeroen Huizingh, P. Wanningen, Johan Verspuij, Martijn Man, Zhaoqing Ding, Adrian Apetri, Başak Kükrer, Eveline Sneekes-Vriese, Danuta Tomkiewicz, N. Laursen, Peter Lee, A. Zakrzewska, Liesbeth Dekking, J. Tolboom, Lisanne Tettero, Sander Meerten, Wenli Yu, W. Koudstaal, J. Goudsmit, A. Ward, W. Meijberg, I. Wilson, K. Radošević (2015)
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogenScience, 349
J. Steel, Anice Lowen, Taia Wang, Mark Yondola, Qinshan Gao, Kester Haye, A. García-Sastre, P. Palese (2010)
Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk DomainmBio, 1
Andrew Cox, Steven Baker, Aitor Nogales, L. Martínez-Sobrido, S. Dewhurst (2014)
Development of a Mouse-Adapted Live Attenuated Influenza Virus That Permits In Vivo Analysis of Enhancements to the Safety of Live Attenuated Influenza Virus VaccineJournal of Virology, 89
M. Baz, Myeisha Paskel, Y. Matsuoka, James Zengel, Xing Cheng, H. Jin, K. Subbarao (2013)
Replication and Immunogenicity of Swine, Equine, and Avian H3 Subtype Influenza Viruses in Mice and FerretsJournal of Virology, 87
Alaina Mooney, J. Gabbard, Zhuo Li, D. Dlugolenski, Scott Johnson, Ralph Tripp, B. He, S. Tompkins (2017)
Vaccination with Recombinant Parainfluenza Virus 5 Expressing Neuraminidase Protects against Homologous and Heterologous Influenza Virus ChallengeJournal of Virology, 91
J. Francis, C. Bunce, C. Horlock, J. Watson, S. Warrington, B. Georges, C. Brown (2015)
A novel peptide-based pan-influenza A vaccine: a double blind, randomised clinical trial of immunogenicity and safety.Vaccine, 33 2
T. Babu, M. Levine, T. Fitzgerald, C. Luke, M. Sangster, H. Jin, D. Topham, J. Katz, J. Treanor, K. Subbarao (2014)
Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine.Vaccine, 32 50
S. Epstein, C. Lo, J. Misplon, C. Lawson, B. Hendrickson, E. Max, K. Subbarao (1997)
Mechanisms of heterosubtypic immunity to lethal influenza A virus infection in fully immunocompetent, T cell-depleted, beta2-microglobulin-deficient, and J chain-deficient mice.Journal of immunology, 158 3
Sook-san Wong, Bryan Kaplan, Mark Zanin, J. Debeauchamp, L. Kercher, J. Crumpton, P. Seiler, Yilun Sun, L. Tang, S. Krauss, R. Webster, R. Webby (2015)
Impact of Adjuvants on the Immunogenicity and Efficacy of Split-Virion H7N9 Vaccine in Ferrets.The Journal of infectious diseases, 212 4
Frances Gotch, A. McMichael, Geoffrey Smith, Bernard Moss (1987)
Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytesThe Journal of Experimental Medicine, 165
S. Leddon, K. Richards, J. Treanor, A. Sant (2015)
Abundance and specificity of influenza reactive circulating memory follicular helper and non‐follicular helper CD4 T cells in healthy adultsImmunology, 146
E. Kilbourne, W. Laver, J. Schulman, R. Webster (1968)
Antiviral Activity of Antiserum Specific for an Influenza Virus NeuraminidaseJournal of Virology, 2
P. Lillie, T. Berthoud, T. Powell, T. Lambe, Caitlin Mullarkey, Alexandra Spencer, M. Hamill, Yanchun Peng, M. Blais, C. Duncan, S. Sheehy, T. Havelock, S. Faust, Rob Williams, A. Gilbert, J. Oxford, T. Dong, A. Hill, S. Gilbert (2012)
Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in HumansClinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 55
Grace Chen, E. Lamirande, H. Jin, G. Kemble, K. Subbarao (2010)
Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.Virology, 398 1
H. Nohynek, J. Jokinen, M. Partinen, O. Vaarala, T. Kirjavainen, J. Sundman, S. Himanen, C. Hublin, I. Julkunen, P. Olsen, O. Saarenpää-Heikkilä, T. Kilpi (2012)
AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in FinlandPLoS ONE, 7
A. Broadbent, Celia Santos, Amanda Anafu, E. Wimmer, S. Mueller, K. Subbarao (2016)
Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets.Vaccine, 34 4
K. Talaat, R. Karron, C. Luke, Bhagvanji Thumar, Bridget McMahon, Grace Chen, E. Lamirande, H. Jin, K. Coelingh, G. Kemble, K. Subbarao (2011)
An open label Phase I trial of a live attenuated H6N1 influenza virus vaccine in healthy adults.Vaccine, 29 17
G. Giudice, A. Hilbert, R. Bugarini, A. Minutello, O. Popova, D. Toneatto, Ines Schoendorf, A. Borkowski, R. Rappuoli, A. Podda (2006)
An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.Vaccine, 24 16
Sietske Huber, J. Beek, J. Jonge, W. Luytjes, D. Baarle (2014)
T Cell Responses to Viral Infections – Opportunities for Peptide VaccinationFrontiers in Immunology, 5
Chengjun Li, M. Hatta, D. Burke, Jihui Ping, Ying Zhang, M. Ozawa, A. Taft, Subash Das, A. Hanson, Jiasheng Song, M. Imai, Peter Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, K. Iwatsuki-Horimoto, C. Russell, Sarah James, E. Skepner, E. Maher, G. Neumann, A. Klimov, A. Kelso, J. McCauley, Dayan Wang, Y. Shu, T. Odagiri, M. Tashiro, Xiyan Xu, D. Wentworth, J. Katz, N. Cox, Derek Smith, Y. Kawaoka (2016)
Selection of antigenically advanced variants of seasonal influenza virusesNature Microbiology, 1
R. Clark, B. Chong, N. Mirchandani, N. Brinster, K. Yamanaka, R. Dowgiert, T. Kupper (2006)
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin1The Journal of Immunology, 176
T. Joseph, J. McAuliffe, Bin Lu, H. Jin, G. Kemble, K. Subbarao (2007)
Evaluation of Replication and Pathogenicity of Avian Influenza A H7 Subtype Viruses in a Mouse ModelJournal of Virology, 81
Gayathri Bommakanti, Xianghan Lu, M. Citron, T. Najar, G. Heidecker, J. Meulen, R. Varadarajan, X. Liang (2012)
Design of Escherichia coli-Expressed Stalk Domain Immunogens of H1N1 Hemagglutinin That Protect Mice from Lethal ChallengeJournal of Virology, 86
D. Masopust, V. Vezys, A. Marzo, L. Lefrançois (2001)
Preferential Localization of Effector Memory Cells in Nonlymphoid TissueScience, 291
K. Boonnak, Y. Matsuoka, Weijia Wang, Amorsolo Suguitan, Zhongying Chen, Myeisha Paskel, M. Baz, Ian Moore, H. Jin, K. Subbarao (2017)
Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype VirusesJournal of Virology, 91
Wilbur Chen, Lisa Jackson, Kathryn Edwards, W. Keitel, H. Hill, D. Noah, C. Creech, Shital Patel, B. Mangal, K. Kotloff (2015)
Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 AdjuvantClinical and Vaccine Immunology, 23
B. Giles, T. Ross (2012)
Computationally optimized antigens to overcome influenza viral diversityExpert Review of Vaccines, 11
Tao Wu, Yinghong Hu, Young‐Tae Lee, K. Bouchard, Alexandre Benechet, K. Khanna, L. Cauley (2014)
Lung‐resident memory CD8 T cells (TRM) are indispensable for optimal cross‐protection against pulmonary virus infectionJournal of Leukocyte Biology, 95
Melkamu Getie‐Kebtie, I. Sultana, M. Eichelberger, M. Alterman (2012)
Label‐free mass spectrometry‐based quantification of hemagglutinin and neuraminidase in influenza virus preparations and vaccinesInfluenza and Other Respiratory Viruses, 7
Donald Carter, Christopher Darby, Bradford Lefoley, C. Crevar, T. Alefantis, R. Oomen, Stephen Anderson, Tod Strugnell, Guadalupe Cortés-Garcia, T. Vogel, M. Parrington, H. Kleanthous, T. Ross (2016)
Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza VirusesJournal of Virology, 90
T. Sutton, S. Chakraborty, V. Mallajosyula, E. Lamirande, Ketaki Ganti, Kevin Bock, Ian Moore, R. Varadarajan, K. Subbarao (2017)
Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccinesNPJ Vaccines, 2
C. Turley, R. Rupp, Casey Johnson, David Taylor, J. Wolfson, L. Tussey, U. Kavita, L. Stanberry, A. Shaw (2011)
Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults.Vaccine, 29 32
M. Sobhanie, Y. Matsuoka, Sinthujan Jegaskanda, T. Fitzgerald, R. Mallory, Zhongying Chen, C. Luke, J. Treanor, K. Subbarao (2015)
Evaluation of the Safety and Immunogenicity of a Candidate Pandemic Live Attenuated Influenza Vaccine (pLAIV) Against Influenza A(H7N9)The Journal of Infectious Diseases, 213
K. Yap, G. Ada, I. McKenzie (1978)
Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virusNature, 273
Ka Chung, Elizabeth Coyle, D. Jani, L. King, Rukmini Bhardwaj, L. Fries, Gale Smith, G. Glenn, H. Golding, S. Khurana (2015)
ISCOMATRIX™ adjuvant promotes epitope spreading and antibody affinity maturation of influenza A H7N9 virus like particle vaccine that correlate with virus neutralization in humans.Vaccine, 33 32
B. Chua, C. Wong, Edin Mifsud, K. Edenborough, Toshiki Sekiya, Amabel Tan, F. Mercuri, S. Rockman, Weisan Chen, S. Turner, P. Doherty, A. Kelso, L. Brown, D. Jackson (2015)
Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive ImmunitymBio, 6
H. Wan, Jin Gao, Kemin Xu, Hongjun Chen, Laura Couzens, Katie Rivers, J. Easterbrook, Kevin Yang, Lei Zhong, M. Rajabi, Jianqiang Ye, I. Sultana, X. Wan, Xiufan Liu, D. Pérez, J. Taubenberger, M. Eichelberger (2013)
Molecular Basis for Broad Neuraminidase Immunity: Conserved Epitopes in Seasonal and Pandemic H1N1 as Well as H5N1 Influenza VirusesJournal of Virology, 87
J. Langley, L. Frenette, L. Ferguson, D. Riff, E. Sheldon, G. Risi, Casey Johnson, Ping Li, R. Kenney, B. Innis, L. Fries (2010)
Safety and cross-reactive immunogenicity of candidate AS03-adjuvanted prepandemic H5N1 influenza vaccines: a randomized controlled phase 1/2 trial in adults.The Journal of infectious diseases, 201 11
Hailong Guo, Steven Baker, L. Martínez-Sobrido, D. Topham (2014)
Induction of CD8 T Cell Heterologous Protection by a Single Dose of Single-Cycle Infectious Influenza VirusJournal of Virology, 88
Taheri Sathaliyawala, Masaru Kubota, N. Yudanin, D. Turner, Philip Camp, J. Thome, K. Bickham, H. Lerner, Michael Goldstein, M. Sykes, Tomoaki Kato, D. Farber (2013)
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets.Immunity, 38 1
J. Ledgerwood, Chih-Jen Wei, Zonghui Hu, Ingelise Gordon, M. Enama, C. Hendel, P. McTamney, Melissa Pearce, H. Yassine, J. Boyington, R. Bailer, T. Tumpey, R. Koup, J. Mascola, G. Nabel, B. Graham (2011)
DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trialsThe Lancet. Infectious Diseases, 11
P. Pitisuttithum, K. Boonnak, Supat Chamnanchanunt, P. Puthavathana, V. Luvira, H. Lerdsamran, J. Kaewkungwal, S. Lawpoolsri, V. Thanachartwet, U. Silachamroon, Wanibtisam Masamae, A. Schuetz, P. Wirachwong, Sit Thirapakpoomanunt, L. Rudenko, E. Sparrow, M. Friede, M. Kieny (2017)
Safety and immunogenicity of a live attenuated influenza H5 candidate vaccine strain A/17/turkey/Turkey/05/133 H5N2 and its priming effects for potential pre-pandemic use: a randomised, double-blind, placebo-controlled trialThe Lancet. Infectious Diseases, 17
B. Murphy, J. Kasel, R. Chanock (1972)
Association of serum anti-neuraminidase antibody with resistance to influenza in man.The New England journal of medicine, 286 25
LA Grohskopf, LZ Sokolow, AM Fry, EB Walter, DB Jernigan (2018)
Update: ACIP recommendations for the use of quadrivalent live attenuated influenza vaccine (LAIV4)—United States, 2018–19 influenza seasonMMWR Morb Mortal Wkly Rep, 67
R. Couch, J. Kasel, J. Gerin, J. Schulman, E. Kilbourne (1974)
Induction of partial immunity to influenza by a neuraminidase-specific vaccine.The Journal of infectious diseases, 129 4
A. Hayward, Lili Wang, N. Goonetilleke, E. Fragaszy, A. Bermingham, A. Copas, O. Dukes, Elizabeth Millett, I. Nazareth, J. Nguyen-Van-Tam, J. Watson, M. Zambon, Anne Johnson, A. McMichael (2015)
Natural T Cell-mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study.American journal of respiratory and critical care medicine, 191 12
Guillaume Stewart-Jones, Andrew McMichael, John Bell, David Stuart, E. Jones (2003)
A structural basis for immunodominant human T cell receptor recognitionNature Immunology, 4
B. Young, Xiahong Zhao, A. Cook, C. Parry, A. Wilder-Smith, Mark I-Cheng (2017)
Do antibody responses to the influenza vaccine persist year-round in the elderly? A systematic review and meta-analysis.Vaccine, 35 2
B. Slütter, L. Pewe, P. Lauer, J. Harty (2013)
Cutting Edge: Rapid Boosting of Cross-Reactive Memory CD8 T Cells Broadens the Protective Capacity of the Flumist VaccineThe Journal of Immunology, 190
S. Sarawar, Yasuko Hatta, Shinji Watanabe, Peter Dias, G. Neumann, Y. Kawaoka, P. Bilsel (2016)
M2SR, a novel live single replication influenza virus vaccine, provides effective heterosubtypic protection in mice.Vaccine, 34 42
J. Sui, W. Hwang, S. Pérez, G. Wei, Daniel Aird, Li-mei Chen, E. Santelli, B. Stec, G. Cadwell, M. Ali, H. Wan, A. Murakami, Anuradha Yammanuru, T. Han, N. Cox, L. Bankston, R. Donis, R. Liddington, W. Marasco (2009)
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A virusesNature Structural & Molecular Biology, 16
D. Hoft, Elizabeth Babusis, S. Worku, C. Spencer, Kathleen Lottenbach, S. Truscott, G. Abate, Isaac Sakala, K. Edwards, C. Creech, M. Gerber, D. Bernstein, F. Newman, Irene Graham, E. Anderson, R. Belshe (2011)
Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children.The Journal of infectious diseases, 204 6
S. Mueller, J. Coleman, Dimitris Papamichail, Charles Ward, A. Nimnual, B. Futcher, S. Skiena, E. Wimmer (2010)
Live Attenuated Influenza Vaccines by Computer-Aided Rational DesignNature biotechnology, 28
Yao-qing Chen, Teddy Wohlbold, Nai-Ying Zheng, Min Huang, Yunping Huang, Karlynn Neu, Jiwon Lee, H. Wan, Karla Rojas, Ericka Kirkpatrick, Carole Henry, Anna-Karin Palm, Christopher Stamper, L. Lan, D. Topham, J. Treanor, J. Wrammert, R. Ahmed, M. Eichelberger, G. Georgiou, F. Krammer, P. Wilson (2018)
Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive AntibodiesCell, 173
T. Hoskins, J. Davies, Alison Smith, A. Allchin, Christine Miller, T. Pollock (1976)
INFLUENZA AT CHRIST'S HOSPITAL: MARCH, 1974The Lancet, 307
M. DeDiego, C. Anderson, Hongmei Yang, J. Holden-Wiltse, T. Fitzgerald, J. Treanor, D. Topham (2016)
Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine‐mediated immune protectionImmunology, 148
N. Wu, I. Wilson (2017)
A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.Journal of molecular biology, 429 17
David Taylor, J. Treanor, E. Sheldon, Casey Johnson, S. Umlauf, Langzhou Song, U. Kavita, Ge Liu, L. Tussey, K. Ozer, T. Hofstaetter, A. Shaw (2012)
Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response.Vaccine, 30 39
M. Sandbulte, K. Westgeest, Jin Gao, Xiyan Xu, A. Klimov, C. Russell, D. Burke, Derek Smith, R. Fouchier, M. Eichelberger (2011)
Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza virusesProceedings of the National Academy of Sciences, 108
S. Morgan, Johanneke Hemmink, Emily Porter, R. Harley, Holly Shelton, M. Aramouni, H. Everett, S. Brookes, M. Bailey, Alain Townsend, B. Charleston, E. Tchilian (2016)
Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 VirusThe Journal of Immunology Author Choice, 196
C. Sandt, M. Hillaire, M. Geelhoed-Mieras, A. Osterhaus, R. Fouchier, G. Rimmelzwaan (2015)
Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.The Journal of infectious diseases, 212 1
O. Pleguezuelos, Stuart Robinson, G. Stoloff, W. Caparrós‐Wanderley (2012)
Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled Phase I trial.Vaccine, 30 31
K. Casey, Kathryn Fraser, J. Schenkel, Amy Moran, Michael Abt, Lalit Beura, P. Lucas, D. Artis, E. Wherry, K. Hogquist, V. Vezys, D. Masopust (2012)
Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in TissuesThe Journal of Immunology, 188
Maryna Eichelberger, William Allan, M. Zijlstra, Rudolf Jaenisch, Peter Doherty (1991)
Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cellsThe Journal of Experimental Medicine, 174
Tomy Joseph, J. McAuliffe, Bin Lu, Leatrice Vogel, D. Swayne, H. Jin, G. Kemble, K. Subbarao (2008)
A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets.Virology, 378 1
J. Galson, J. Trück, J. Trück, D. Kelly, R. Most (2016)
Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccinationScientific Reports, 6
S. Alam, Zackery Knowlden, M. Sangster, A. Sant (2013)
CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus InfectionJournal of Virology, 88
L. Wakim, Joanna Smith, I. Caminschi, M. Lahoud, J. Villadangos (2015)
Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infectionMucosal Immunology, 8
J. Ravetch (2010)
In vivo veritas: the surprising roles of Fc receptors in immunityNature Immunology, 11
R. Morita, N. Schmitt, S. Bentebibel, R. Ranganathan, L. Bourdery, G. Zurawski, E. Foucat, M. Dullaers, SangKon Oh, Natalie Sabzghabaei, Elizabeth Lavecchio, M. Punaro, V. Pascual, J. Banchereau, H. Ueno (2011)
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.Immunity, 34 1
B. Johansson, D. Bucher, E. Kilbourne (1989)
Purified influenza virus hemagglutinin and neuraminidase are equivalent in stimulation of antibody response but induce contrasting types of immunity to infectionJournal of Virology, 63
Toshiki Sekiya, J. Yamagishi, J. Gray, Paul Whitney, A. Martinelli, W. Zeng, C. Wong, C. Sugimoto, D. Jackson, B. Chua (2017)
PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8+ T cell responses.Biomaterials, 137
C. Tully, Senthil Chinnakannan, Caitlin Mullarkey, M. Ulaszewska, F. Ferrara, Nigel Temperton, S. Gilbert, T. Lambe (2017)
Novel Bivalent Viral-Vectored Vaccines Induce Potent Humoral and Cellular Immune Responses Conferring Protection against Stringent Influenza A Virus ChallengeThe Journal of Immunology, 199
D. Jackson, Yuk-Fai Lau, T. Le, A. Suhrbier, G. Deliyannis, C. Cheers, Corey Smith, W. Zeng, L. Brown (2004)
A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses.Proceedings of the National Academy of Sciences of the United States of America, 101 43
J. Schulman, M. Khakpour, E. Kilbourne (1968)
Protective Effects of Specific Immunity to Viral Neuraminidase on Influenza Virus Infection of MiceJournal of Virology, 2
M. Eichelberger, Laura Couzens, Yonghong Gao, M. Levine, J. Katz, R. Wagner, C. Thompson, K. Höschler, K. Laurie, T. Bai, O. Engelhardt, J. Wood (2016)
Comparability of neuraminidase inhibition antibody titers measured by enzyme-linked lectin assay (ELLA) for the analysis of influenza vaccine immunogenicity.Vaccine, 34 4
Y. Wen, L. Mu, Yan Shi (2016)
Immunoregulatory functions of immune complexes in vaccine and therapyEMBO Molecular Medicine, 8
Laurel Lee, Do Ha, C. Simmons, M. Jong, N. Chau, R. Schumacher, Yanchun Peng, A. McMichael, J. Farrar, Geoffrey Smith, A. Townsend, B. Askonas, S. Rowland-Jones, T. Dong (2008)
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals.The Journal of clinical investigation, 118 10
M. Baz, K. Boonnak, Myeisha Paskel, Celia Santos, T. Powell, Alain Townsend, K. Subbarao (2015)
Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal ChallengemBio, 6
L. Jackson, J. Campbell, S. Frey, Kathryn Edwards, W. Keitel, K. Kotloff, Andrea Berry, Irene Graham, R. Atmar, C. Creech, I. Thomsen, Shital Patel, Andres Gutierrez, E. Anderson, H. Sahly, H. Hill, D. Noah, A. Bellamy (2015)
Effect of Varying Doses of a Monovalent H7N9 Influenza Vaccine With and Without AS03 and MF59 Adjuvants on Immune Response: A Randomized Clinical Trial.JAMA, 314 3
Jad Maamary, Taia Wang, G. Tan, P. Palese, J. Ravetch (2017)
Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunizationProceedings of the National Academy of Sciences, 114
Junwei Li, Maria Arévalo, Yanping Chen, Shan Chen, Mingtao Zeng (2014)
T-cell-mediated cross-strain protective immunity elicited by prime-boost vaccination with a live attenuated influenza vaccine.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 27
C McClaren, CW Potter, LC Jennings (1974)
Immunity to influenza in ferrets. XIII. Protection against influenza infection by serum antibody to homologous haemagglutinin or neuraminidase antigensMed Microbiol Immunol, 160
K. Mohn, G. Bredholt, K. Brokstad, R. Pathirana, H. Aarstad, C. Tøndel, R. Cox (2014)
Longevity of B-Cell and T-Cell Responses After Live Attenuated Influenza Vaccination in ChildrenThe Journal of Infectious Diseases, 211
Takehiro Ura, K. Okuda, M. Shimada (2014)
Developments in Viral Vector-Based VaccinesVaccines, 2
Laura Couzens, Jin Gao, K. Westgeest, M. Sandbulte, V. Lugovtsev, R. Fouchier, M. Eichelberger (2014)
An optimized enzyme-linked lectin assay to measure influenza A virus neuraminidase inhibition antibody titers in human sera.Journal of virological methods, 210
N. Young, R. Pebody, Gillian Smith, B. Olowokure, Giri Shankar, K. Hoschler, M. Galiano, H. Green, A. Wallensten, Angela Hogan, I. Oliver (2013)
International flight-related transmission of pandemic influenza A(H1N1)pdm09: an historical cohort study of the first identified cases in the United KingdomInfluenza and Other Respiratory Viruses, 8
T. Powell, J. Silk, Jane Sharps, E. Fodor, Alain Townsend (2012)
Pseudotyped Influenza A Virus as a Vaccine for the Induction of Heterotypic ImmunityJournal of Virology, 86
S. Quiñones-Parra, E. Grant, L. Loh, Thi Nguyen, Kristy-Anne Campbell, S. Tong, Adrian Miller, P. Doherty, D. Vijaykrishna, J. Rossjohn, S. Gras, K. Kedzierska (2014)
Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicitiesProceedings of the National Academy of Sciences, 111
A. Iwasaki, Padmini Pillai (2014)
Innate immunity to influenza virus infectionNature Reviews Immunology, 14
E. Belongia, M. Simpson, J. King, M. Sundaram, Nicholas Kelley, M. Osterholm, H. McLean (2016)
Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies.The Lancet. Infectious diseases, 16 8
Bradley Bender, Thomas Croghan, Liping Zhang, Parker Small (1992)
Transgenic mice lacking class I major histocompatibility complex- restricted T cells have delayed viral clearance and increased mortality after influenza virus challengeThe Journal of Experimental Medicine, 175
T. Doyle, A. Hashem, Changgui Li, G. Domselaar, L. Larocque, Junzhi Wang, Daryl Smith, T. Cyr, A. Farnsworth, R. He, A. Hurt, E. Brown, Xuguang Li (2013)
Universal anti-neuraminidase antibody inhibiting all influenza A subtypes.Antiviral research, 100 2
Despite the widespread use of seasonal influenza vaccines, there is urgent need for a universal influenza vaccine to provide broad, long-term protection. A number of factors underpin this urgency, including threats posed by zoonotic and pandemic influenza A viruses, suboptimal effectiveness of seasonal influenza vaccines, and concerns surrounding the effects of annual vaccination. In this article, we discuss approaches that are being investigated to increase influenza vaccine breadth, which are near-term, readily achievable approaches to increase the range of strains recognized within a subtype, or longer-term more challenging approaches to produce a truly universal influenza vaccine. Adjuvanted and neuraminidase-optimized vaccines are emerging as the most feasible and promising approaches to extend protection to cover a broader range of strains within a subtype. The goal of developing a universal vaccine has also been advanced with the design of immunogenic influenza HA-stem constructs that induce broadly neutralizing antibodies. However, these constructs are not yet sufficiently immunogenic to induce lasting universal immunity in humans. Advances in understanding how T cells mediate protection, and how viruses are packaged, have facilitated the rationale design and delivery of replication-incompetent virus vaccines that induce broad protection mediated by lung-resident memory T cells. While the lack of clear mechanistic correlates of protection, other than haemagglutination-inhibiting antibodies, remains an impediment to further advancing novel influenza vaccines, the pressing need for such a vaccine is supporting development of highly innovative and effective strategies.
Drugs – Springer Journals
Published: Aug 7, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.