Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/metabolic-syndrome-androgens-and-hypertension-Hr5oTYViJR
References (57)
-
D. Yach, D. Stuckler, K. Brownell (2006)
Epidemiologic and economic consequences of the global epidemics of obesity and diabetesNature Medicine, 12
-
M. Harvie, M. Pegington, M. Mattson, J. Frystyk, B. Dillon, G. Evans, J. Cuzick, S. Jebb, B. Martin, R. Cutler, T. Son, Stuart Maudsley, O. Carlson, J. Egan, A. Flyvbjerg, A. Howell (2011)
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight womenInternational Journal of Obesity, 35
-
C. Malkin, P. Pugh, Richard Jones, D. Kapoor, K. Channer, T. Jones (2004)
The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men.The Journal of clinical endocrinology and metabolism, 89 7
-
J. Carrero, A. Qureshi, P. Parini, S. Arver, B. Lindholm, P. Bárány, O. Heimbürger, P. Stenvinkel (2009)
Low serum testosterone increases mortality risk among male dialysis patients.Journal of the American Society of Nephrology : JASN, 20 3
-
E. Diamanti-Kandarakis (2008)
Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implicationsExpert Reviews in Molecular Medicine, 10
-
R. Stanworth, T. Jones (2009)
Testosterone in obesity, metabolic syndrome and type 2 diabetes.Frontiers of hormone research, 37
-
A. Traish, Kyriakos Kypreos (2011)
Testosterone and cardiovascular disease: an old idea with modern clinical implications.Atherosclerosis, 214 2
-
Y. Şahin, K. Unluhizarci, Ayse Yilmazsoy, A. Yıkılmaz, E. Aygen, F. Keleştimur (2007)
The effects of metformin on metabolic and cardiovascular risk factors in nonobese women with polycystic ovary syndromeClinical Endocrinology, 67
-
P. Mårin, Sten Holmtäng, C. Gustafsson, ‡Lars Jönsson, ‡Henry Kvist, A. Elander, J. Eldh, L. Sjöström, G. Holm, P. Björntorp (1993)
Androgen treatment of abdominally obese men.Obesity research, 1 4
-
I. Pérez-Torres, Priscilla Roque, M. Hafidi, E. Díaz-Diaz, G. Baños (2009)
Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of genderFree Radical Research, 43
-
E. Diamanti-Kandarakis (2006)
Insulin resistance in PCOSEndocrine, 30
-
V. Giagulli, Jean Kaufman, A. Vermeulen (1994)
Pathogenesis of the decreased androgen levels in obese men.The Journal of clinical endocrinology and metabolism, 79 4
-
G. Laughlin, E. Barrett-Connor, D. Kritz-Silverstein, D. Mühlen (2000)
Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study.The Journal of clinical endocrinology and metabolism, 85 2
-
I Perez-Torres, P Roque, M Hafidi (2009)
Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of genderFree Rad Biol Med, 43
-
L. Mannerås, S. Cajander, A. Holmäng, Zamira Seleskovic, T. Lystig, M. Lönn, E. Stener-Victorin (2007)
A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.Endocrinology, 148 8
-
P. Mah, Gary Wittert (2010)
Obesity and testicular functionMolecular and Cellular Endocrinology, 316
-
T. Baba, T. Endo, H. Honnma, Y. Kitajima, Takuhiro Hayashi, H. Ikeda, N. Masumori, H. Kamiya, O. Moriwaka, Tsuyoshi Saito (2007)
Association between polycystic ovary syndrome and female-to-male transsexuality.Human reproduction, 22 4
-
P Cano, V Jimenez-Ortega, A Larrad (2008)
Effect of a high-fat diet on 24-h pattern of circulating levels of prolactin, luteinizing hormone and glucose, and pineal melatonin content, in ratsEndocrine, 33
-
E. Whitaker, M. Shaw, G. Hervey (1983)
Plasma oestradiol-17 beta and testosterone concentrations as possible causes of the infertility of congenitally obese Zucker rats.The Journal of endocrinology, 99 3
-
J. Svartberg, D. Mühlen, J. Sundsfjord, R. Jorde (2003)
Waist Circumference and Testosterone Levels in Community Dwelling Men. The Tromsø StudyEuropean Journal of Epidemiology, 19
-
Licy Yanes, J. Sartori-Valinotti, R. Iliescu, D. Romero, L. Racusen, Huiming Zhang, J. Reckelhoff (2009)
Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats.American journal of physiology. Renal physiology, 296 4
-
M. Volterrani, G. Rosano, F. Iellamo (2012)
Testosterone and heart failureEndocrine, 42
-
C. Allan, R. McLachlan (2010)
Androgens and obesityCurrent Opinion in Endocrinology, Diabetes and Obesity, 17
-
A. Traish, F. Saad, R. Feeley, A. Guay (2009)
The dark side of testosterone deficiency: III. Cardiovascular disease.Journal of andrology, 30 5
-
M. Maggio, F. Lauretani, G. Ceda, S. Bandinelli, S. Ling, E. Metter, A. Artoni, L. Carassale, A. Cazzato, G. Ceresini, J. Guralnik, S. Basaria, G. Valenti, L. Ferrucci (2007)
Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study.Archives of internal medicine, 167 20
-
(2010)
• This study showed that with menopause transition, in the absence of any weight gain, the fat depositon in women changes from subcutaneous to visceral -
J. Reckelhoff (2001)
Gender Differences in the Regulation of Blood PressureHypertension: Journal of the American Heart Association, 37
-
D. Schultheiss, S. Machtens, U. Jonas (2004)
Review article Testosterone therapy in the ageing male: what about the prostate?Andrologia, 36
-
O. Nilssen, O. Førde, T. Brenn (1990)
The Tromsø Study. Distribution and population determinants of gamma-glutamyltransferase.American journal of epidemiology, 132 2
-
T. Watanabe, M. Akishita, K. Toba, K. Kozaki, M. Eto, N. Sugimoto, T. Kiuchi, M. Hashimoto, W. Shirakawa, Y. Ouchi (2000)
Influence of sex and age on serum nitrite/nitrate concentration in healthy subjects.Clinica chimica acta; international journal of clinical chemistry, 301 1-2
-
P. Cano, V. Jiménez‐Ortega, Á. Larrad, C. Toso, D. Cardinali, A. Esquifino (2008)
Effect of a high-fat diet on 24-h pattern of circulating levels of prolactin, luteinizing hormone, testosterone, corticosterone, thyroid-stimulating hormone and glucose, and pineal melatonin content, in ratsEndocrine, 33
-
M. Zitzmann, E. Nieschlag (2007)
Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men.The Journal of clinical endocrinology and metabolism, 92 10
-
Jennifer Hill, C. Elias, M. Fukuda, K. Williams, E. Berglund, W. Holland, You-Ree Cho, J. Chuang, Yong Xu, Michelle Choi, D. Lauzon, Charlotte Lee, R. Coppari, J. Richardson, J. Zigman, S. Chua, P. Scherer, B. Lowell, J. Brüning, J. Elmquist (2010)
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.Cell metabolism, 11 4
-
D. Kapoor, K. Channer, T. Jones (2008)
Rosiglitazone increases bioactive testosterone and reduces waist circumference in hypogonadal men with type 2 diabetesDiabetes & Vascular Disease Research, 5
-
A. Vermeulen, Jean Kaufman, J. Deslypere, G. Thomas (1993)
Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men.The Journal of clinical endocrinology and metabolism, 76 5
-
R. Tamler (2009)
Diabetes, obesity, and erectile dysfunction.Gender medicine, 6 Suppl 1
-
M. Kirby, R. Shabsigh, S. Arver, K. Channer, I. Eardley, A. Fabbri, L. Gooren, A. Heufelder, Hugh Jones, S. Meryn, Michael Zitzmann (2008)
The triad of erectile dysfunction, hypogonadism and the metabolic syndromeInternational Journal of Clinical Practice, 62
-
S. Chakrabarti, Yeshao Wen, A. Dobrian, Banumathi Cole, Qian Ma, H. Pei, Michael Williams, Melissa Bevard, G. Vandenhoff, S. Keller, Jiali Gu, J. Nadler (2011)
Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats.American journal of physiology. Endocrinology and metabolism, 300 1
-
A. Olivares, J. Méndez, E. Zambrano, M. Cárdenas, A. Tovar, G. Perera-Marín, A. Ulloa-Aguirre (2010)
Reproductive axis function and gonadotropin microheterogeneity in a male rat model of diet-induced obesity.General and comparative endocrinology, 166 2
-
R. Azziz, E. Carmina, D. Dewailly, E. Diamanti-Kandarakis, H. Escobar-Morreale, W. Futterweit, O. Janssen, R. Legro, R. Norman, A. Taylor, S. Witchel (2006)
Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline.The Journal of clinical endocrinology and metabolism, 91 11
-
K. Khaw, M. Dowsett, E. Folkerd, S. Bingham, N. Wareham, R. Luben, A. Welch, N. Day (2007)
Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men: European Prospective Investigation Into Cancer in Norfolk (EPIC-Norfolk) Prospective Population StudyCirculation, 116
-
J. Reckelhoff, Huiming Zhang, J. Granger (1998)
Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats.Hypertension, 31 1 Pt 2
-
R Azziz, E Carmina, D Dewailly (2006)
Position statement: Criteria for defining polycystic ovary syndrome: An Androgen Excess Society guidelineJ Clin Endocrinol Metab, 91
-
Yasumasa Ikeda, K. Aihara, M. Akaike, Takashi Sato, K. Ishikawa, T. Ise, S. Yagi, T. Iwase, Yuka Ueda, S. Yoshida, H. Azuma, K. Walsh, T. Tamaki, S. Kato, Toshio Matsumoto (2010)
Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice.Molecular endocrinology, 24 7
-
T. Nielsen, C. Hagen, K. Wraae, K. Brixen, P. Petersen, E. Haug, R. Larsen, M. Andersen (2007)
Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men.The Journal of clinical endocrinology and metabolism, 92 7
-
J. Reckelhoff, L. Fortepiani (2004)
Novel mechanisms responsible for postmenopausal hypertension.Hypertension, 43 5
-
A. Isidori, M. Caprio, F. Strollo, C. Moretti, G. Frajese, A. Isidori, A. Fabbri (1999)
Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels.The Journal of clinical endocrinology and metabolism, 84 10
-
T. Nedungadi, D. Clegg (2009)
Sexual Dimorphism in Body Fat Distribution and Risk for Cardiovascular DiseasesJournal of Cardiovascular Translational Research, 2
-
L. Cattaneo, V. Colonna, M. Zoli, E. Müller, D. Cocchi (1996)
Characterization of the hypothalamo-pituitary-IGF-I axis in rats made obese by overfeeding.The Journal of endocrinology, 148 2
-
N. Mazer (2009)
A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: With illustrative examples from male and female populationsSteroids, 74
-
LL Yanes, R Iliescu, JC Sartori-Valinotti (2009)
Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive ratsAm J Physiol Reg Integr Comp Physiol, 296
-
D. Sieveking, P. Lim, R. Chow, L. Dunn, S. Bao, K. McGrath, A. Heather, David Handelsman, D. Celermajer, M. Ng (2010)
A sex-specific role for androgens in angiogenesisThe Journal of Experimental Medicine, 207
-
N. Ozbey, E. Sencer, S. Molvalilar, Y. Orhan (2002)
Body fat distribution and cardiovascular disease risk factors in pre- and postmenopausal obese women with similar BMI.Endocrine journal, 49 4
-
M. Akishita, Shiho Fukai, M. Hashimoto, Y. Kameyama, K. Nomura, Tetsuro Nakamura, S. Ogawa, K. Iijima, M. Eto, Y. Ouchi (2010)
Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese menHypertension Research, 33
-
K. Flegal, M. Carroll, C. Ogden, L. Curtin (2010)
Prevalence and trends in obesity among US adults, 1999-2008.JAMA, 303 3
-
S. Ho, Shenghui Wu, S. Chan, A. Sham (2010)
Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal womenInternational Journal of Obesity, 34
-
E. Drakos, G. Rassidakis, L. Medeiros (2008)
Mammalian target of rapamycin (mTOR) pathway signalling in lymphomasExpert Reviews in Molecular Medicine, 10
- Publisher
- Springer Journals
- Copyright
- Copyright © 2011 by Springer Science+Business Media, LLC
- Subject
- Medicine & Public Health; Cardiology; General Practice / Family Medicine; Internal Medicine; Primary Care Medicine; Metabolic Diseases; Nephrology
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- DOI
- 10.1007/s11906-011-0184-0
- pmid
- 21274756
- Publisher site
- See Article on Publisher Site
Abstract
Obesity is one of the constellation of factors that make up the definition of the metabolic syndrome. Metabolic syndrome is also associated with insulin resistance, dyslipidemia, hypertriglyceridemia, and type 2 diabetes mellitus. The presence of obesity and metabolic syndrome in men and women is also associated with increased risk of cardiovascular disease and hypertension. In men, obesity and metabolic syndrome are associated with reductions in testosterone levels. In women, obesity and metabolic syndrome are associated with increases in androgen levels. In men, reductions in androgen levels are associated with inflammation, and androgen supplements reduce inflammation. In women, increases in androgens are associated with increases in inflammatory cytokines, and reducing androgens reduces inflammation. This review discusses the possibility that the effects of androgens on metabolic syndrome and its sequelae may differ between males and females.
Journal
Current Hypertension Reports – Springer Journals
Published: Jan 29, 2011