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Gabriela Castilho, L. Okuda, R. Pinto, Rodgiro Iborra, E. Nakandakare, Célio Santos, F. Laurindo, M. Passarelli (2012)
ER stress is associated with reduced ABCA-1 protein levels in macrophages treated with advanced glycated albumin - reversal by a chemical chaperone.The international journal of biochemistry & cell biology, 44 7
C. Kuder, J. Neighbors, R. Hohl, D. Wiemer (2009)
Synthesis and biological activity of a fluorescent schweinfurthin analogue.Bioorganic & medicinal chemistry, 17 13
Yongjun Wang, P. Rogers, Chen Su, G. Varga, K. Stayrook, T. Burris (2008)
Regulation of Cholesterologenesis by the Oxysterol Receptor, LXRα*Journal of Biological Chemistry, 283
Nolan Mente, A. Wiemer, J. Neighbors, J. Beutler, R. Hohl, D. Wiemer (2007)
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.Bioorganic & medicinal chemistry letters, 17 4
Michael Brown, J. Goldstein (1997)
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription FactorCell, 89
L. Maletínská, E. Blakely, K. Bjornstad, D. Deen, L. Knoff, T. Forte (2000)
Human glioblastoma cell lines: levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein.Cancer research, 60 8
R. Stupp, Warren Mason, M. Bent, M. Weller, B. Fisher, M. Taphoorn, K. Bélanger, A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, Robert Janzer, Samuel Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J. Cairncross, E. Eisenhauer, R. Mirimanoff (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.The New England journal of medicine, 352 10
(2005)
The schweinfurthins: issues in development of a plant-derived anticancer lead Medicinal and aromatic plants
J. Beutler, R. Shoemaker, Tanya Johnson, M. Boyd (1998)
Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.Journal of natural products, 61 12
J. Topczewski, C. Kuder, J. Neighbors, R. Hohl, D. Wiemer (2010)
Fluorescent schweinfurthin B and F analogs with anti-proliferative activity.Bioorganic & medicinal chemistry, 18 18
T. Turbyville, D. Gürsel, R. Tuskan, Jessica Walrath, C. Lipschultz, S. Lockett, D. Wiemer, J. Beutler, Karlyne Reilly (2010)
Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD–Dependent MannerMolecular Cancer Therapeutics, 9
Michael Sinensky, L. Beck, Sherry Leonard, R. Evans (1990)
Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis.The Journal of biological chemistry, 265 32
Natalie Ulrich, J. Kodet, Nolan Mente, C. Kuder, J. Beutler, R. Hohl, D. Wiemer (2010)
Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.Bioorganic & medicinal chemistry, 18 4
M. Heverin, S. Meaney, D. Lütjohann, U. Diczfalusy, J. Wahren, I. Björkhem (2005)
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.Journal of lipid research, 46 5
E. Treadwell, J. Neighbors, D. Wiemer (2002)
A cascade cyclization approach to schweinfurthin B.Organic letters, 4 21
JA Beutler, J Jato, G Cragg, DF Wiemer, JD Neighbors, MS Salnikova, M Hollingshead, DA Scudiero, TG McCloud (2005)
The schweinfurthins: issues in development of a plant‐derived anticancer lead
C. Kuder, Ryan Sheehy, J. Neighbors, D. Wiemer, R. Hohl (2012)
Functional Evaluation of a Fluorescent Schweinfurthin: Mechanism of Cytotoxicity and Intracellular QuantificationMolecular Pharmacology, 82
Deliang Guo, Felicia Reinitz, M. Youssef, Cynthia Hong, D. Nathanson, D. Akhavan, Daisuke Kuga, Ali Amzajerdi, H. Soto, Shaojun Zhu, I. Babic, Kazuhiro Tanaka, Julie Dang, A. Iwanami, B. Gini, Jason DeJesus, Dominique Lisiero, Tiffany Huang, R. Prins, P. Wen, H. Robins, M. Prados, L. Deangelis, I. Mellinghoff, M. Mehta, C. James, A. Chakravarti, T. Cloughesy, P. Tontonoz, P. Mischel (2011)
An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway.Cancer discovery, 1 5
J. Kodet, J. Beutler, D. Wiemer (2014)
Synthesis and structure activity relationships of schweinfurthin indoles.Bioorganic & medicinal chemistry, 22 8
Deqin Ma, C. Nutt, Piam Shanehsaz, Xuejun Peng, D. Louis, D. Kaetzel (2005)
Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors.Cancer research, 65 13
(2014)
Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells
Natalie Ulrich, C. Kuder, R. Hohl, D. Wiemer (2010)
Biologically active biotin derivatives of schweinfurthin F.Bioorganic & medicinal chemistry letters, 20 22
A Baldan, DD Bojanic, PA Edwards (2009)
The ABCs of sterol transport, 50
D. Covell, Ruili Huang, A. Wallqvist (2007)
Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening dataMolecular Cancer Therapeutics, 6
J. Schultz, H. Tu, Alvin Luk, J. Repa, J. Medina, Leping Li, S. Schwendner, Shelley Wang, M. Thoolen, D. Mangelsdorf, K. Lustig, B. Shan (2000)
Role of LXRs in control of lipogenesis.Genes & development, 14 22
J. Neighbors, Maya Salnikova, J. Beutler, D. Wiemer (2006)
Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity.Bioorganic & medicinal chemistry, 14 6
V. Sorrentino, J. Nelson, E. Maspero, A. Marques, L. Scheer, Simona Polo, N. Zelcer (2013)
The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation[S]Journal of Lipid Research, 54
Winnie Luu, Laura Sharpe, I. Gelissen, Andrew Brown (2013)
The role of signalling in cellular cholesterol homeostasisIUBMB Life, 65
Nolan Mente, J. Neighbors, D. Wiemer (2008)
BF3 x Et2O-mediated cascade cyclizations: synthesis of schweinfurthins F and G.The Journal of organic chemistry, 73 20
Anthony Burgett, Thomas Poulsen, K. Wangkanont, D Anderson, Chikako Kikuchi, K. Shimada, S. Okubo, K. Fortner, Y. Mimaki, M. Kuroda, Jason Murphy, David Schwalb, Eugene Petrella, I. Cornella-Taracido, M. Schirle, John Tallarico, M. Shair (2011)
Natural products reveal cancer cell dependence on oxysterol-binding proteins.Nature chemical biology, 7 9
S. Holstein, C. Kuder, H. Tong, R. Hohl (2011)
Pleiotropic Effects of a Schweinfurthin on Isoprenoid HomeostasisLipids, 46
K. Bowden, N. Ridgway (2008)
OSBP Negatively Regulates ABCA1 Protein Stability*Journal of Biological Chemistry, 283
J. Topczewski, M. Callahan, J. Kodet, Jery Inbarasu, Nolan Mente, J. Beutler, D. Wiemer (2011)
Relevance of the C-5 position to schweinfurthin induced cytotoxicity.Bioorganic & medicinal chemistry, 19 24
B. Janowski, P. Willy, T. Devi, J. Falck, D. Mangelsdorf (1996)
An oxysterol signalling pathway mediated by the nuclear receptor LXRαNature, 383
F. Ohka, A. Natsume, T. Wakabayashi (2012)
Current Trends in Targeted Therapies for Glioblastoma MultiformeNeurology Research International, 2012
J. Neighbors, J. Beutler, D. Wiemer (2005)
Synthesis of nonracemic 3-deoxyschweinfurthin B.The Journal of organic chemistry, 70 3
(1995)
Prediction of biochemical mechanism of action from the in vitro antitumor screen of the National Cancer Institute . In: Foye WO (ed) Cancer chemotherapeutic agents
J. Topczewski, J. Kodet, D. Wiemer (2011)
Exploration of cascade cyclizations terminated by tandem aromatic substitution: total synthesis of (+)-schweinfurthin A.The Journal of organic chemistry, 76 3
Motohiro Sekiya, D. Yamamuro, Taichi Ohshiro, A. Honda, Manabu Takahashi, M. Kumagai, Kent Sakai, Shuichi Nagashima, H. Tomoda, Masaki Igarashi, H. Okazaki, H. Yagyu, J. Osuga, S. Ishibashi (2014)
Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages[S]Journal of Lipid Research, 55
KD Paull (1995)
Prediction of biochemical mechanism of action from the in vitro antitumor screen of the National Cancer Institute
The schweinfurthins have potent antiproliferative activity in multiple glioblastoma multiforme (GBM) cell lines; however, the mechanism by which growth is impeded is not fully understood. Previously, we demonstrated that the schweinfurthins reduce the level of key isoprenoid intermediates in the cholesterol biosynthetic pathway. Herein, we describe the effects of the schweinfurthins on cholesterol homeostasis. Intracellular cholesterol levels are greatly reduced in cells incubated with 3‐deoxyschweinfurthin B (3dSB), an analog of the natural product schweinfurthin B. Decreased cholesterol levels are due to decreased cholesterol synthesis and increased cholesterol efflux; both of these cellular actions can be influenced by liver X‐receptor (LXR) activation. The effects of 3dSB on ATP‐binding cassette transporter 1 levels and other LXR targets are similar to that of 25‐hydroxycholesterol, an LXR agonist. Unlike 25‐hydroxycholesterol, 3dSB does not act as a direct agonist for LXR α or β. These data suggest that cholesterol homeostasis plays a significant role in the growth inhibitory activity of the schweinfurthins and may elucidate a mechanism that can be targeted in human cancers such as GBM.
Lipids – Wiley
Published: Dec 1, 2015
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