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(2014)
Clival chordomas: a pathological, surgical, and radiotherapeutic 512 Journal of Neuro-Oncology (2020) 147:503–513 1 3 review
S. Potluri, S. Jefferies, R. Jena, F. Harris, K. Burton, A. Prevost, N. Burnet (2011)
Residual postoperative tumour volume predicts outcome after high-dose radiotherapy for chordoma and chondrosarcoma of the skull base and spine.Clinical oncology (Royal College of Radiologists (Great Britain)), 23 3
D. Weber, H. Rutz, E. Pedroni, A. Bolsi, B. Timmermann, J. Verwey, A. Lomax, G. Goitein (2005)
Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of the skull base: the Paul Scherrer Institut experience.International journal of radiation oncology, biology, physics, 63 2
D. Schulz‐Ertner, A. Nikoghosyan, B. Didinger, C. Karger, O. Jäkel, M. Wannenmacher, J. Debus (2003)
Treatment planning intercomparison for spinal chordomas using intensity-modulated photon radiation therapy (IMRT) and carbon ions.Physics in medicine and biology, 48 16
J. Fernandez-Miranda, P. Gardner, C. Snyderman, K. Devaney, W. Mendenhall, C. Suárez, A. Rinaldo, A. Ferlito (2014)
Clival chordomas: A pathological, surgical, and radiotherapeutic reviewHead & Neck, 36
Å. Palm, K. Johansson (2007)
A review of the impact of photon and proton external beam radiotherapy treatment modalities on the dose distribution in field and out-of-field; implications for the long-term morbidity of cancer survivorsActa Oncologica, 46
S. Combs, M. Ellerbrock, T. Haberer, D. Habermehl, A. Hoess, O. Jäkel, A. Jensen, S. Klemm, M. Münter, J. Naumann, A. Nikoghosyan, S. Oertel, K. Parodi, S. Rieken, J. Debus (2010)
Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patientsActa Oncologica, 49
(1994)
Methodo - logical quality and synthesis of case series and case reports
S. Duval, R. Tweedie (2000)
Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐AnalysisBiometrics, 56
D. Moher, A. Liberati, J. Tetzlaff, D. Altman (2009)
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA StatementOpen Medicine, 3
G. Noël, L. Feuvret, R. Ferrand, G. Boisserie, J. Mazeron, J. Habrand (2004)
Radiotherapeutic Factors in the Management of Cervical-basal Chordomas and ChondrosarcomasNeurosurgery, 55
M. McDonald, O. Linton, M. Moore, J. Ting, A. Cohen-Gadol, M. Shah (2015)
Influence of Residual Tumor Volume and Radiation Dose Coverage in Outcomes for Clival Chordoma.International journal of radiation oncology, biology, physics, 95 1
S. Combs, Adriana Kalbe, A. Nikoghosyan, B. Ackermann, O. Jäkel, T. Haberer, J. Debus (2011)
Carbon ion radiotherapy performed as re-irradiation using active beam delivery in patients with tumors of the brain, skull base and sacral region.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 98 1
G. Kraft (1999)
RBE and its interpretationStrahlentherapie und Onkologie, 175
D. Schulz‐Ertner, A. Nikoghosyan, H. Hof, B. Didinger, S. Combs, O. Jäkel, C. Karger, L. Edler, J. Debus (2007)
Carbon ion radiotherapy of skull base chondrosarcomas.International journal of radiation oncology, biology, physics, 67 1
S. Rieken, D. Habermehl, A. Nikoghosyan, A. Jensen, T. Haberer, O. Jäkel, M. Münter, T. Welzel, J. Debus, S. Combs (2011)
Assessment of early toxicity and response in patients treated with proton and carbon ion therapy at the Heidelberg ion therapy center using the raster scanning technique.International journal of radiation oncology, biology, physics, 81 5
M. Egger, G. Smith, Martin Schneider, C. Minder (1997)
Bias in meta-analysis detected by a simple, graphical testBMJ, 315
J. Debus, E. Hug, N. Liebsch, D. O'Farrel, D. Finkelstein, J. Efird, J. Munzenrider (1997)
Brainstem tolerance to conformal radiotherapy of skull base tumors.International journal of radiation oncology, biology, physics, 39 5
Mayo Clinic, Hitachi to build first, next generation, carbon ion therapy treatment facility in North America. The Mayo Clinic
M. Heffelfinger, D. Dahlin, C. Maccarty, J. Beabout (1973)
Chordomas and cartilaginous tumors at the skull baseCancer, 32
J. Mizoe, A. Hasegawa, R. Takagi, H. Bessho, Takeshi Onda, H. Tsujii (2009)
Carbon ion radiotherapy for skull base chordoma.Skull base : official journal of North American Skull Base Society ... [et al.], 19 3
J. Munzenrider, N. Liebsch (1999)
Proton therapy for tumors of the skull baseStrahlentherapie und Onkologie, 175
(2018)
Proton beam therapy for skull base chordomas in 106 patients: a dose adaptive radiation protocol. Radiother Oncol 128(2):198–202
M. Hu, Liyang Jiang, Xiangli Cui, Jianguang Zhang, Jinming Yu (2018)
Proton beam therapy for cancer in the era of precision medicineJournal of Hematology & Oncology, 11
M. Uhl, M. Mattke, T. Welzel, J. Oelmann, G. Habl, A. Jensen, M. Ellerbrock, T. Haberer, K. Herfarth, J. Debus (2014)
High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: First report of long‐term resultsCancer, 120
(2014)
Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: first longterm results. Cancer 120(21):3410–3417
Versione, Francesco Grossi (2020)
Common Terminology Criteria for Adverse EventsDefinitions
G. Wells, G. Wells, B. Shea, B. Shea, Dianne O'Connell, J. Peterson, Welch, M. Losos, P. Tugwell, Sb Ga, G. Zello, J. Petersen (2014)
The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses
X. Guan, Jing Gao, Jiyi Hu, Weixu Hu, Jing Yang, Xianxin Qiu, Chaosu Hu, L. Kong, Jiade Lu (2019)
The preliminary results of proton and carbon ion therapy for chordoma and chondrosarcoma of the skull base and cervical spineRadiation Oncology (London, England), 14
Vivien Fung, V. Calugaru, S. Bolle, H. Mammar, C. Alapetite, P. Maingon, L. Marzi, S. Froelich, J. Habrand, R. Dendale, G. Noël, L. Feuvret (2018)
Proton beam therapy for skull base chordomas in 106 patients: A dose adaptive radiation protocol.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 128 2
M. Amichetti, D. Amelio, M. Cianchetti, R. Enrici, G. Minniti (2010)
A systematic review of proton therapy in the treatment of chondrosarcoma of the skull baseNeurosurgical Review, 33
M. Jägersberg, Amir Rahal, P. Dammann, D. Merkler, D. Weber, K. Schaller (2017)
Clival chordoma: a single-centre outcome analysisActa Neurochirurgica, 159
C. Ares, E. Hug, A. Lomax, A. Bolsi, B. Timmermann, H. Rutz, J. Schuller, E. Pedroni, G. Goitein (2009)
Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report.International journal of radiation oncology, biology, physics, 75 4
Stephanie Combs, A. Nikoghosyan, O. Jaekel, C. Karger, T. Haberer, M. Münter, P. Huber, J. Debus, D. Schulz‐Ertner (2009)
Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull baseCancer, 115
M. Mattke, Kira Vogt, N. Bougatf, T. Welzel, J. Oelmann-Avendano, H. Hauswald, A. Jensen, M. Ellerbrock, O. Jäkel, T. Haberer, K. Herfarth, J. Debus, M. Uhl (2018)
High control rates of proton‐ and carbon‐ion–beam treatment with intensity‐modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy CenterCancer, 124
M. Uhl, M. Mattke, T. Welzel, F. Roeder, J. Oelmann, G. Habl, A. Jensen, M. Ellerbrock, O. Jäkel, T. Haberer, K. Herfarth, J. Debus (2014)
Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: First long‐term resultsCancer, 120
A. Peeters, J. Grutters, M. Pijls-Johannesma, S. Reimoser, D. Ruysscher, J. Severens, M. Joore, P. Lambin (2010)
How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 95 1
N. Averbeck, J. Topsch, M. Scholz, W. Kraft-Weyrather, M. Durante, G. Taucher‐Scholz (2016)
Efficient Rejoining of DNA Double-Strand Breaks despite Increased Cell-Killing Effectiveness following Spread-Out Bragg Peak Carbon-Ion IrradiationFrontiers in Oncology, 6
D. Weber, F. Murray, C. Combescure, V. Calugaru, C. Alapetite, F. Albertini, S. Bolle, F. Goudjil, A. Pica, M. Walser, H. Mammar, B. Bachtiary, T. Lomax, G. Noël, R. Dendale, L. Feuvret (2018)
Long term outcome of skull-base chondrosarcoma patients treated with high-dose proton therapy with or without conventional radiation therapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 129 3
(2020)
first report of long-term results
Nicholas Volpe, N. Liebsch, J. Munzenrider, Simmons Lesseil (1993)
Neuro-ophthalmologic findings in chordoma and chondrosarcoma of the skull base.American journal of ophthalmology, 115 1
A. Giuffrida, Jorge Burgueno, L. Koniaris, J. Gutierrez, R. Duncan, S. Scully (2009)
Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database.The Journal of bone and joint surgery. American volume, 91 5
D. Moher, A. Liberati, J. Tetzlaff, D. Altman (2009)
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementPLoS Medicine, 6
C. Begg, Madhuchhanda Mazumdar (1994)
Operating characteristics of a rank correlation test for publication bias.Biometrics, 50 4
N. Smoll, O. Gautschi, I. Radovanovic, K. Schaller, D. Weber (2013)
Incidence and relative survival of chordomasCancer, 119
(2014)
Clival chordomas: a pathological, surgical, and radiotherapeutic Journal of Neuro-Oncology 1 3 review
D. Schulz‐Ertner, C. Karger, A. Feuerhake, A. Nikoghosyan, S. Combs, O. Jäkel, L. Edler, M. Scholz, J. Debus (2007)
Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas.International journal of radiation oncology, biology, physics, 68 2
(1999)
RBE and its interpretation. Strahlenther Onkol 175(Suppl 2):44–47
Makoto Anzai, N. Yamamoto, K. Hayashi, M. Nakajima, A. Nomoto, K. Ogawa, H. Tsuji (2019)
Safety and Efficacy of Carbon-ion Radiotherapy Alone for Stage III Non-small Cell Lung CancerAntiCancer Research, 40
O. Bloch, B. Jian, I. Yang, S. Han, Derick Aranda, Brian Ahn, A. Parsa (2009)
A systematic review of intracranial chondrosarcoma and survivalJournal of Clinical Neuroscience, 16
J. Leeman, P. Romesser, Ying Zhou, S. McBride, N. Riaz, E. Sherman, Marc Cohen, O. Cahlon, N. Lee (2017)
Proton therapy for head and neck cancer: expanding the therapeutic window.The Lancet. Oncology, 18 5
R. Imai, T. Kamada, N. Araki (2016)
Carbon Ion Radiation Therapy for Unresectable Sacral Chordoma: An Analysis of 188 Cases.International journal of radiation oncology, biology, physics, 95 1
K. Almefty, S. Pravdenkova, B. Colli, O. Al-Mefty, M. Gokden (2007)
Chordoma and chondrosarcoma: Similar, but quite different, skull base tumorsCancer, 110
D. Schulz‐Ertner, T. Haberer, O. Jäkel, C. Thilmann, M. Krämer, W. Enghardt, G. Kraft, M. Wannenmacher, J. Debus (2002)
Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions.International journal of radiation oncology, biology, physics, 53 1
(2009)
Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base. Cancer 115(6):1348–1355. https ://doi
D. Atkins, D. Best, P. Briss, M. Eccles, Y. Falck-Ytter, S. Flottorp, G. Guyatt, R. Harbour, M. Haugh, D. Henry, S. Hill, Roman Jaeschke, G. Leng, A. Liberati, N. Magrini, J. Mason, P. Middleton, J. Mrukowicz, Dianne O'Connell, A. Oxman, B. Phillips, H. Schünemann, T. Edejer, H. Varonen, G. Vist, John Williams, S. Zaza (2004)
Grading quality of evidence and strength of recommendationsBMJ : British Medical Journal, 328
M. Murad, S. Sultan, S. Haffar, F. Bazerbachi (2018)
Methodological quality and synthesis of case series and case reportsBMJ Evidence-Based Medicine, 23
J. Higgins, S. Thompson, J. Deeks, D. Altman (2003)
Measuring inconsistency in meta-analysesBMJ : British Medical Journal, 327
M. Takagi, Y. Demizu, Fumiko Nagano, K. Terashima, O. Fujii, D. Jin, M. Mima, Y. Niwa, K. Katsui, Masaki Suga, T. Yamashita, T. Akagi, K. Sakata, N. Fuwa, T. Okimoto (2018)
Treatment outcomes of proton or carbon ion therapy for skull base chordoma: a retrospective studyRadiation Oncology (London, England), 13
M. Freeman, J. Tukey (1950)
Transformations Related to the Angular and the Square RootAnnals of Mathematical Statistics, 21
BackgroundCarbon ion radiotherapy (CIRT) is an emerging radiation therapy to treat skull base chordomas and chondrosarcomas. To date, its use is limited to a few centers around the world, and there has been no attempt to systematically evaluate survival and toxicity outcomes reported in the literature. Correspondingly, the aim of this study was to qualitatively and quantitatively assess these outcomes.MethodsA systematic search of seven electronic databases from inception to November 2019 was conducted following PRISMA guidelines. Articles were screened against pre-specified criteria. Outcomes were then pooled by random-effects meta-analyses of proportions.ResultsA total of nine studies provided unique metadata for assessment, with six originating from Heidelberg, Germany. The surveyed cohort size was 632 patients, with 389 (62%) chordomas and 243 (38%) chondrosarcomas of the skull base. Across all studies, median cohort age at therapy and female proportion were 46 years and 51% respectively. Estimates of local control incidence at 1-, 5-, and 10-years in chordoma-only studies were 99%, 80%, and 56%, and in chondrosarcoma-only studies were 99%, 89%, and 88%. Estimates of overall survival probability at 1-, 5-, and 10-years in chordoma-only studies were 100%, 94%, and 78%, and in chondrosarcoma-only studies were 99%, 95%, and 79%. The incidence of early and late toxicity (Grade ≥ 3) ranged from 0 to 4% across all study groups.ConclusionsThe emerging use of CIRT to treat skull base chordomas and chondrosarcomas appear promising with regard to tumor control, overall survival, and risk profile of early and late toxicity. The current literature suffers from the fact only a few centers in the world currently employ this technology.
Journal of Neuro-Oncology – Springer Journals
Published: May 23, 2020
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