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(2015)
MYBL 2 guides
F. Ahmed (2019)
Integrated Network Analysis Reveals FOXM1 and MYBL2 as Key Regulators of Cell Proliferation in Non-small Cell Lung CancerFrontiers in Oncology, 9
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B-myb Is Required for Inner Cell Mass Formation at an Early Stage of Development*The Journal of Biological Chemistry, 274
C. Selman, L. Partridge (2012)
c-MYB and TGFb: EMT’s dynamic duo in breast cancer
S. Heinrichs, Lily Conover, C. Bueso-Ramos, O. Kilpivaara, K. Stevenson, D. Neuberg, M. Loh, Wen‐shu Wu, S. Rodig, G. Garcia-Manero, H. Kantarjian, A. Look (2013)
MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancyeLife, 2
Mingfeng Shao, Z. Ren, Rongjun Zhang (2018)
MYBL2 protects against H9c2 injury induced by hypoxia via AKT and NF‑κB pathways.Molecular medicine reports, 17 3
A. Sala (2012)
c-MYB and TGFβ: EMT’s dynamic duo in breast cancerCell Cycle, 11
Cara Martin, K. Astbury, Louise Kehoe, Jacqueline O'Crowley, S. O’Toole, J. O'Leary (2015)
The use of MYBL2 as a novel candidate biomarker of cervical cancer.Methods in molecular biology, 1249
Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang (2017)
GEPIA: a web server for cancer and normal gene expression profiling and interactive analysesNucleic Acids Research, 45
F. Cui, Jianpeng Hu, Zhipeng Xu, Jian Tan, Huaming Tang (2019)
Overexpression of NCAPH is upregulated and predicts a poor prognosis in prostate cancer.Oncology letters, 17 6
Xiaoyan Fan, Yitao Wang, Tinghui Jiang, W. Cai, Yuelei Jin, Yulong Niu, Huifang Zhu, Y. Bu (2018)
B-Myb Mediates Proliferation and Migration of Non-Small-Cell Lung Cancer via Suppressing IGFBP3International Journal of Molecular Sciences, 19
Z. Guan, W. Cheng, D. Huang, A. Wei (2017)
High MYBL2 expression and transcription regulatory activity is associated with poor overall survival in patients with hepatocellular carcinoma.Current research in translational medicine, 66 1
Jia Yuan, Ying Zhang, Yue Sheng, Xiazhou Fu, Hanhua Cheng, R. Zhou (2015)
MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammalsAutophagy, 11
M. Frau, S. Ladu, D. Calvisi, M. Simile, P. Bonelli, L. Daino, M. Tomasi, M. Seddaiu, F. Feo, R. Pascale (2011)
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.Journal of hepatology, 55 1
Takayuki Arai, S. Kojima, Yasutaka Yamada, S. Sugawara, Mayuko Kato, K. Yamazaki, Y. Naya, T. Ichikawa, N. Seki (2019)
Micro‐ribonucleic acid expression signature of metastatic castration‐resistant prostate cancer: Regulation of NCAPH by antitumor miR‐199a/b‐3pInternational Journal of Urology, 26
C. Ward, G. Volpe, P. Cauchy, A. Ptasinska, Ruba Almaghrabi, D. Blakemore, Monica Nafria, Doris Kestner, J. Frampton, G. Murphy, Y. Buganim, K. Kaji, P. García (2018)
Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic ReprogrammingCell Reports, 24
Kana Fujii, T. Murase, Shintaro Beppu, K. Saida, H. Takino, A. Masaki, K. Ijichi, K. Kusafuka, Y. Iida, T. Onitsuka, Y. Yatabe, N. Hanai, Y. Hasegawa, H. Inagaki (2017)
MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinomaHistopathology, 71
J. Musa, M. Aynaud, Olivier Mirabeau, O. Delattre, T. Grünewald (2017)
MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesisCell Death & Disease, 8
H. Shi, Melanie Bevier, R. Johansson, Kerstin Enquist-Olsson, R. Henriksson, K. Hemminki, P. Lenner, A. Försti (2012)
Prognostic impact of polymorphisms in the MYBL2 interacting genes in breast cancerBreast Cancer Research and Treatment, 131
Fei Ren, Lisha Wang, Xiaohan Shen, Xiuying Xiao, Zebing Liu, P. Wei, Yi-qin Wang, P. Qi, Chen Shen, W. Sheng, Xiang Du (2015)
MYBL2 is an independent prognostic marker that has tumor-promoting functions in colorectal cancer.American journal of cancer research, 5 4
Mary Clarke, S. Dumon, C. Ward, Roland Jäger, S. Freeman, B. Dawood, L. Sheriff, M. Lorvellec, R. Kralovics, Jon Frampton, P. García (2012)
MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasiaLeukemia, 27
Yong-xu Jia, Yaping Gao, Jing Li, Z. Chang, Jie Yan, Y. Qin (2019)
Prognostic implications of MYBL2 in resected Chinese gastric adenocarcinoma patientsOncoTargets and therapy, 12
Hiroyuki Shimomura, T. Sasahira, Chie Nakashima, Miyako Kurihara-Shimomura, T. Kirita (2019)
Non-SMC Condensin I Complex Subunit H (NCAPH) Is Associated with Lymphangiogenesis and Drug Resistance in Oral Squamous Cell CarcinomaJournal of Clinical Medicine, 9
M. Lorvellec, S. Dumon, Apolinar Maya, Mendoza, D. Jackson, J. Frampton (2010)
EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS B-Myb is Critical for Proper DNA Duplication During an Unperturbed S Phase in Mouse Embryonic Stem Cells
Jianli Chen, Xiaowen Chen (2018)
MYBL2 Is Targeted by miR-143-3p and Regulates Breast Cancer Cell Proliferation and Apoptosis.Oncology research, 26 6
Haibin Liang, Yang Cao, Q. Ma, Yi-Jun Shu, Zheng-min Wang, Fei Zhang, Yuan-yuan Ye, Huai-feng Li, Shan-shan Xiang, Xiao-ling Song, Yi Xu, Yi-chi Zhang, Run-fa Bao, Ruiyan Yuan, Yijian Zhang, Yun-ping Hu, Lin Jiang, Maolan Li, Xu-an Wang, Xiang-song Wu, Wen-guang Wu, Shuai Zhao, Yong Fand, Xiaoming Cui, Yunshu Lu, Jian Zhou, Lei Zheng, W. Gong, Ying-bin Liu (2017)
MYBL2 is a Potential Prognostic Marker that Promotes Cell Proliferation in Gallbladder CancerCellular Physiology and Biochemistry, 41
Mark Sandberg, S. Sutton, M. Pletcher, T. Wiltshire, L. Tarantino, J. Hogenesch, M. Cooke (2005)
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.Developmental cell, 8 2
L. Yin, Li-Ping Jiang, Qiushuo Shen, Qiu-xia Xiong, Xiao Zhuo, Long Zhang, Hai-jing Yu, Xiang Guo, Ying Luo, Jian-feng Dong, Q. Kong, Cui-ping Yang, Yong-Bin Chen (2017)
NCAPH plays important roles in human colon cancerCell Death & Disease, 8
MYB Proto-Oncogene Like 2 (MYBL2) is a highly conserved member of the Myb family of transcription factors and plays a critical role in regulating cell proliferation and survival. Here we show that overexpression of MYBL2 is frequently observed in lung adenocarcinoma (LUAD) and significantly correlates with advanced stage and poor patient survival. Knockdown of MYBL2 induced apoptosis in lung cancer cells and resulted in significant inhibition of cell proliferation, migration, and invasion. Notably, we identified Non-SMC Condensin I Complex Subunit H (NCAPH) gene as a direct target of MYBL2. NCAPH expression is highly correlated with that of MYBL2 in LUAD cases and is tightly affected by MYBL2 knockdown or overexpression in vitro. Chromatin immunoprecipitation (ChIP) assays also showed that MYBL2 directly binds to the transcription start site (TSS) of NCAPH. Moreover, we provided evidence that NCAPH functions as an oncogene in lung cancer and overexpression of NCAPH could partially rescue cell death and migration blockage induced by MYBL2 knockdown. Together, these results suggest that overexpression of MYBL2 promotes proliferation and migration of lung cancer cells via upregulating NCAPH, establishing their roles as novel prognostic biomarkers as well as potential therapeutic targets for the disease.
Molecular and Cellular Biochemistry – Springer Journals
Published: May 21, 2020
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