Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Grefkes, G. Fink (2016)
Noninvasive brain stimulation after stroke: it is time for large randomized controlled trials!Current Opinion in Neurology
A. Timmermans, Ryanne Lemmens, Maurice Monfrance, R. Geers, W. Bakx, R. Smeets, H. Seelen (2014)
Effects of task-oriented robot training on arm function, activity, and quality of life in chronic stroke patients: a randomized controlled trialJournal of NeuroEngineering and Rehabilitation, 11
R. Gassert, V. Dietz (2018)
Rehabilitation robots for the treatment of sensorimotor deficits: a neurophysiological perspectiveJournal of NeuroEngineering and Rehabilitation, 15
B. Elsner, G. Kwakkel, J. Kugler, J. Mehrholz (2017)
Transcranial direct current stimulation (tDCS) for improving capacity in activities and arm function after stroke: a network meta-analysis of randomised controlled trialsJournal of NeuroEngineering and Rehabilitation, 14
J. Grotta, E. Noser, T. Ro, C. Boake, H. Levin, J. Aronowski, T. Schallert (2004)
Constraint-Induced Movement TherapyStroke, 35
Ching-yi Wu, Pai-chuan Huang, Yu-Ting Chen, Keh-chung Lin, Hsiu-wen Yang (2013)
Effects of mirror therapy on motor and sensory recovery in chronic stroke: a randomized controlled trial.Archives of physical medicine and rehabilitation, 94 6
F. Grimm, G. Naros, A. Gharabaghi (2016)
Closed-Loop Task Difficulty Adaptation during Virtual Reality Reach-to-Grasp Training Assisted with an Exoskeleton for Stroke RehabilitationFrontiers in Neuroscience, 10
O. Lambercy, L. Dovat, V. Johnson, B. Salman, S. Wong, R. Gassert, T. Milner, T. Leong, E. Burdet (2007)
Development of a Robot-Assisted Rehabilitation Therapy to train Hand Function for Activities of Daily Living2007 IEEE 10th International Conference on Rehabilitation Robotics
C. Kellner (2012)
Brain Stimulation in Psychiatry: Transcranial Direct Current Stimulation (tDCS)
Isabella Menezes, L. Cohen, E. Mello, A. Machado, P. Peckham, S. Anjos, I. Siqueira, Juliana Conti, E. Plow, A. Conforto (2018)
Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor ImpairmentNeuromodulation: Technology at the Neural Interface, 21
G. Schlaug, V. Renga (2008)
Transcranial direct current stimulation: a noninvasive tool to facilitate stroke recoveryExpert Review of Medical Devices, 5
Kimberley Wattchow, M. McDonnell, S. Hillier (2017)
Rehabilitation Interventions for Upper Limb Function in the First Four Weeks Following Stroke: A Systematic Review and Meta-Analysis of the Evidence.Archives of physical medicine and rehabilitation, 99 2
M. Kandel, J. Beis, L. Chapelain, H. Guesdon, J. Paysant (2012)
Non-invasive cerebral stimulation for the upper limb rehabilitation after stroke: a review.Annals of physical and rehabilitation medicine, 55 9-10
R. Lindenberg, V. Renga, Lin Zhu, D. Nair, G. Schlaug (2010)
Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patientsNeurology, 75
D. Bonaiuti, L. Rebasti, P. Sioli (2007)
The constraint induced movement therapy: a systematic review of randomised controlled trials on the adult stroke patients.Europa medicophysica, 43 2
N. Ilić, E. Dubljanin-Raspopović, U. Nedeljković, Sanja Tomanović-Vujadinović, S. Milanović, Ivana Petronić-Marković, T. Ilić (2016)
Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke.Restorative neurology and neuroscience, 34 6
M. McDonnell, C. Stinear (2017)
TMS measures of motor cortex function after stroke: A meta-analysisBrain Stimulation, 10
S Hesse, A Waldner, J Mehrholz (2011)
Combined transcranial direct current stimulation and robot-assisted arm training in subacute stroke patients: An exploratory, randomized multicenter trialNeurorehabil. Neural Repair, 25
S. Straudi, F. Fregni, Carlotta Martinuzzi, Claudia Pavarelli, S. Salvioli, N. Basaglia (2016)
tDCS and Robotics on Upper Limb Stroke Rehabilitation: Effect Modification by Stroke Duration and Type of StrokeBioMed Research International, 2016
D. Kim, J. Lim, Eun Kang, Dae You, Min-Kyun Oh, B. Oh, N. Paik (2010)
Effect of Transcranial Direct Current Stimulation on Motor Recovery in Patients with Subacute StrokeAmerican Journal of Physical Medicine & Rehabilitation, 89
Cristina Santos, Cibele Pimenta, M. Nobre (2007)
The PICO strategy for the research question construction and evidence search.Revista latino-americana de enfermagem, 15 3
A. Fusco, F. Assenza, M. Iosa, Simona Izzo, R. Altavilla, S. Paolucci, F. Vernieri (2014)
The Ineffective Role of Cathodal tDCS in Enhancing the Functional Motor Outcomes in Early Phase of Stroke Rehabilitation: An Experimental TrialBioMed Research International, 2014
Takashi Takebayashi, Kayoko Takahashi, Misa Moriwaki, Tomosaburo Sakamoto, K. Domen (2017)
Improvement of Upper Extremity Deficit after Constraint-Induced Movement Therapy Combined with and without Preconditioning Stimulation Using Dual-hemisphere Transcranial Direct Current Stimulation and Peripheral Neuromuscular Stimulation in Chronic Stroke Patients: A Pilot Randomized Controlled TriaFrontiers in Neurology, 8
M. Cabral, A. Baltar, Rebeka Borba, Silvana Galvão, Luciana Santos, F. Fregni, K. Monte-Silva (2015)
Transcranial direct current stimulation: before, during, or after motor training?NeuroReport, 26
Yeun Kim, J. Ku, Sangwoo Cho, H. Kim, Yun Cho, Teo Lim, Y. Kang (2014)
Facilitation of corticospinal excitability by virtual reality exercise following anodal transcranial direct current stimulation in healthy volunteers and subacute stroke subjectsJournal of NeuroEngineering and Rehabilitation, 11
C. Stinear, P. Barber, P. Smale, J. Coxon, M. Fleming, W. Byblow (2006)
Functional potential in chronic stroke patients depends on corticospinal tract integrity.Brain : a journal of neurology, 130 Pt 1
Gyrd Thrane, O. Friborg, A. Anke, B. Indredavik (2014)
A meta-analysis of constraint-induced movement therapy after stroke.Journal of rehabilitation medicine, 46 9
E. Steultjens, J. Dekker, L. Bouter, J. Nes, E. Cup, C. Ende (2003)
Occupational Therapy for Stroke Patients: A Systematic ReviewStroke: Journal of the American Heart Association, 34
C Grefkes, NS Ward (2014)
Cortical reorganization after stroke: How much and how functional?Neuroscientist, 20
K. Laver, B. Lange, Stacey George, J. Deutsch, G. Saposnik, M. Crotty (2015)
Virtual reality for stroke rehabilitation.The Cochrane database of systematic reviews, 11
D. Tombari, I. Loubinoux, J. Pariente, A. Gerdelat, J. Albucher, J. Tardy, E. Cassol, F. Chollet (2004)
A longitudinal fMRI study: in recovering and then in clinically stable sub-cortical stroke patientsNeuroImage, 23
N. Roche, M. Geiger, B. Bussel (2015)
Mechanisms underlying transcranial direct current stimulation in rehabilitation.Annals of physical and rehabilitation medicine, 58 4
Nestor Bayona, J. Bitensky, K. Salter, R. Teasell (2005)
The Role of Task-Specific Training in Rehabilitation TherapiesTopics in Stroke Rehabilitation, 12
Giacobbe, H. Krebs, B. Volpe, Á. Pascual-Leone, Á. Pascual-Leone, A. Rykman, G. Zeiarati, F. Fregni, F. Fregni, L. Dipietro, G. Thickbroom, D. Edwards (2013)
Transcranial direct current stimulation (tDCS) and robotic practice in chronic stroke: the dimension of timing.NeuroRehabilitation, 33 1
PM Lewis, RH Thomson, JV Rosenfeld, PB Fitzgerald (2016)
Brain neuromodulation techniques: A reviewNeuroscientist, 22
M. Woodbury, C. Velozo, P. Thompson, K. Light, G. Uswatte, E. Taub, C. Winstein, D. Morris, S. Blanton, D. Nichols-Larsen, S. Wolf (2010)
Measurement Structure of the Wolf Motor Function Test: Implications for Motor Control TheoryNeurorehabilitation and Neural Repair, 24
P. Lewis, R. Thomson, J. Rosenfeld, P. Fitzgerald (2016)
Brain Neuromodulation TechniquesThe Neuroscientist, 22
S. Palmer, S. Navaneethan, J. Craig, David Johnson, V. Perkovic, Sagar Nigwekar, J. Hegbrant, G. Strippoli (2013)
HMG CoA reductase inhibitors (statins) for dialysis patients.The Cochrane database of systematic reviews, 9
H. Clark, George Wells, C. Huët, F. McAlister, L. Salmi, D. Fergusson, A. Laupacis (1999)
Assessing the quality of randomized trials: reliability of the Jadad scale.Controlled clinical trials, 20 5
L. Triccas, J. Burridge, A. Hughes, K. Meadmore, M. Donovan-Hall, J. Rothwell, G. Verheyden (2018)
A qualitative study exploring views and experiences of people with stroke undergoing transcranial direct current stimulation and upper limb robot therapyTopics in Stroke Rehabilitation, 25
A. Butler, Margaret Shuster, Erin O'Hara, K. Hurley, Dionne Middlebrooks, K. Guilkey (2013)
A meta-analysis of the efficacy of anodal transcranial direct current stimulation for upper limb motor recovery in stroke survivors.Journal of hand therapy : official journal of the American Society of Hand Therapists, 26 2
K. Schiene, C. Bruehl, K. Zilles, Meishu Qu, G. Hagemann, M. Kraemer, O. Witte (1996)
Neuronal Hyperexcitability and Reduction of GABAA-Receptor Expression in the Surround of Cerebral PhotothrombosisJournal of Cerebral Blood Flow & Metabolism, 16
N. Bolognini, G. Vallar, C. Casati, L. Latif, Rasheda El-Nazer, J. Williams, E. Banco, D. Macea, L. Tesio, Cecilia Chessa, F. Fregni (2011)
Neurophysiological and Behavioral Effects of tDCS Combined With Constraint-Induced Movement Therapy in Poststroke PatientsNeurorehabilitation and Neural Repair, 25
R. Sparing, F. Mottaghy (2008)
Noninvasive brain stimulation with transcranial magnetic or direct current stimulation (TMS/tDCS)-From insights into human memory to therapy of its dysfunction.Methods, 44 4
Stéphanie Dehem, M. Gilliaux, T. Lejeune, E. Delaunois, P. Mbonda, Y. Vandermeeren, C. Detrembleur, G. Stoquart (2018)
Effectiveness of a single session of dual-transcranial direct current stimulation in combination with upper limb robotic-assisted rehabilitation in chronic stroke patients: a randomized, double-blind, cross-over studyInternational Journal of Rehabilitation Research, 41
Sook-Joung Lee, M. Chun (2014)
Combination transcranial direct current stimulation and virtual reality therapy for upper extremity training in patients with subacute stroke.Archives of physical medicine and rehabilitation, 95 3
L. Triccas, J. Burridge, A. Hughes, R. Pickering, M. Desikan, J. Rothwell, G. Verheyden (2016)
Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysisClinical Neurophysiology, 127
D. Moher, A. Liberati, J. Tetzlaff, D. Altman (2009)
METHODS OF SYSTEMATIC REVIEWS AND META-ANALYSIS Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
María Calderón, Adrián Borrego, J. Latorre, C. Font, M. Alcañiz, M. Sánchez-Ledesma, E. Noé, R. Lloréns (2018)
Combined Transcranial Direct Current Stimulation and Virtual Reality-Based Paradigm for Upper Limb Rehabilitation in Individuals with Restricted Movements. A Feasibility Study with a Chronic Stroke Survivor with Severe HemiparesisJournal of Medical Systems, 42
D. Nair, V. Renga, R. Lindenberg, Lin Zhu, G. Schlaug (2011)
Optimizing recovery potential through simultaneous occupational therapy and non-invasive brain-stimulation using tDCS.Restorative neurology and neuroscience, 29 6
A. Lo, P. Guarino, L. Richards, J. Haselkorn, G. Wittenberg, D. Federman, R. Ringer, T. Wagner, H. Krebs, B. Volpe, C. Bever, D. Bravata, P. Duncan, B. Corn, Alysia Maffucci, S. Nadeau, Susan Conroy, J. Powell, Grant Huang, P. Peduzzi (2010)
Robot-assisted therapy for long-term upper-limb impairment after stroke.The New England journal of medicine, 362 19
A. Beydoun, W. Nasreddine, S. Atweh (2008)
Efficacy and tolerability of pregabalin in partial epilepsyExpert Review of Neurotherapeutics, 8
MH Rabadi, CE Aston (2017)
Effect of transcranial direct current stimulation on severely affected arm-hand motor function in patients after an acute ischemic strokeAm. J. Phys. Med. Rehabil., 96
Hayley Thair, Amy Holloway, R. Newport, Alastair Smith (2017)
Transcranial Direct Current Stimulation (tDCS): A Beginner's Guide for Design and ImplementationFrontiers in Neuroscience, 11
D Moher, A Liberati, J Tetzlaff, DG Altman (2009)
Preferred Reportin items for systematic reviews and meta-analyses: The PRISMA statementPLoS Med., 6
J. Kropotov (2016)
Transcranial Direct Current Stimulation
B. Dobkin, Andrew Dorsch (2013)
New Evidence for Therapies in Stroke RehabilitationCurrent Atherosclerosis Reports, 15
S. Yaghi, M. Pilot, Christopher Song, Christina Blum, A. Yakhkind, B. Silver, K. Furie, M. Elkind, Dean Sherzai, A. Sherzai (2016)
Ischemic Stroke Risk After Acute Coronary SyndromeJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 5
M. Fleming, J. Rothwell, L. Sztriha, J. Teo, D. Newham (2017)
The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after strokeClinical Neurophysiology, 128
V. Sattler, B. Acket, N. Raposo, J. Albucher, C. Thalamas, I. Loubinoux, F. Chollet, M. Simonetta-Moreau (2015)
Anodal tDCS Combined With Radial Nerve Stimulation Promotes Hand Motor Recovery in the Acute Phase After Ischemic StrokeNeurorehabilitation and Neural Repair, 29
D. Simonetti, L. Zollo, S. Milighetti, S. Miccinilli, M. Bravi, F. Ranieri, G. Magrone, E. Guglielmelli, V. Lazzaro, S. Sterzi (2017)
Literature Review on the Effects of tDCS Coupled with Robotic Therapy in Post Stroke Upper Limb RehabilitationFrontiers in Human Neuroscience, 11
Cheryl Carrico, K. Chelette, P. Westgate, Elizabeth Salmon-Powell, L. Nichols, L. Sawaki (2016)
Randomized Trial of Peripheral Nerve Stimulation to Enhance Modified Constraint-Induced Therapy After StrokeAmerican Journal of Physical Medicine & Rehabilitation, 95
M. Rabadi, C. Aston (2017)
Effect of Transcranial Direct Current Stimulation on Severely Affected Arm-Hand Motor Function in Patients After an Acute Ischemic Stroke: A Pilot Randomized Control TrialAmerican Journal of Physical Medicine & Rehabilitation, 96
G. Kwakkel, J. Veerbeek, E. Wegen, S. Wolf (2015)
Constraint-induced movement therapy after strokeThe Lancet Neurology, 14
A. Felice, V. Daloli, S. Masiero, P. Manganotti (2016)
Contralesional Cathodal versus Dual Transcranial Direct Current Stimulation for Decreasing Upper Limb Spasticity in Chronic Stroke Individuals: A Clinical and Neurophysiological Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 25 12
T. Cochrane (2013)
Off-Protocol Access to Study TherapiesTopics in Stroke Rehabilitation, 20
Johanna Lee, V. Groot, H. Beckerman, R. Wagenaar, G. Lankhorst, L. Bouter (2001)
The intra- and interrater reliability of the action research arm test: a practical test of upper extremity function in patients with stroke.Archives of physical medicine and rehabilitation, 82 1
L. Triccas, Jane Burridge, A. Hughes, G. Verheyden, M. Desikan, J. Rothwell (2015)
A double-blinded randomised controlled trial exploring the effect of anodal transcranial direct current stimulation and uni-lateral robot therapy for the impaired upper limb in sub-acute and chronic stroke.NeuroRehabilitation, 37 2
S. Hesse, A. Waldner, J. Mehrholz, C. Tomelleri, Michael Pohl, C. Werner (2011)
Combined Transcranial Direct Current Stimulation and Robot-Assisted Arm Training in Subacute Stroke PatientsNeurorehabilitation and Neural Repair, 25
P. Govender, L. Kalra (2007)
Benefits of occupational therapy in stroke rehabilitationExpert Review of Neurotherapeutics, 7
D. Gladstone, C. Danells, S. Black (2002)
The Fugl-Meyer Assessment of Motor Recovery after Stroke: A Critical Review of Its Measurement PropertiesNeurorehabilitation and Neural Repair, 16
N. Kang, J. Summers, J. Cauraugh (2015)
Transcranial direct current stimulation facilitates motor learning post-stroke: a systematic review and meta-analysisJournal of Neurology, Neurosurgery & Psychiatry, 87
C. Grefkes, N. Ward (2014)
Cortical Reorganization After StrokeThe Neuroscientist, 20
R. Barker, Toby Gill, S. Brauer (2007)
‘Factors contributing to upper limb recovery after stroke: A survey of stroke survivors in Queensland Australia’Disability and Rehabilitation, 29
M. Levin, M. Baniña, S. Frenkel-Toledo, S. Berman, N. Soroker, J. Solomon, D. Liebermann (2018)
Personalized upper limb training combined with anodal-tDCS for sensorimotor recovery in spastic hemiparesis: study protocol for a randomized controlled trialTrials, 19
R. Viana, Glória Laurentino, R. Souza, J. Fonseca, E. Filho, S. Dias, L. Teixeira-Salmela, K. Monte-Silva (2014)
Effects of the addition of transcranial direct current stimulation to virtual reality therapy after stroke: a pilot randomized controlled trial.NeuroRehabilitation, 34 3
Transcranial direct current stimulation is one of the non-invasive techniques whose main mechanism of action is based on its modulation of cortical excitability. The objective of this study is to analyze the variables (i.e, demographics, clinicals, stimulation parameters) that could influence into the responses during rehabilitation of the upper extremity in patients with stroke. Our systematic review has been performed by searching full-text articles published from January 2008 to December 2018 in Embase, Medline, PubMed and Cochrane Library databases. Studies with adult patients with ischemic or hemorrhagic stroke at any stage of evolution were included. We compared interventions with any type of transcranial direct current stimulation (anodal, cathodal or bihemispheric, also known as dual) regarding improvement of upper extremity motor function. We included 14 studies with 368 patients, of whom almost 89% have ischemic etiology and more than half are males. Most patients were considered subacute or chronic, while only two studies were selected with patients in the acute phase. Different methods of using transcranial direct current stimulation with several complementary therapies were identified, such as virtual reality, robot therapy, Occupational Therapy, Physiotherapy, Constraint Induced Movement Therapy or Peripheral Nerve Stimulation. In conclusion, there is not significant evidence due to heterogeneity of clinical data and therapies. Clinical studies with greater number of participants and protocols standardized could outline this assessment in future studies.
Journal of Medical Systems – Springer Journals
Published: Feb 8, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.