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A. Mainio, Satu Tuunanen, H. Hakko, A. Niemelä, J. Koivukangas, P. Räsänen (2006)
Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: a follow-up from 1990 to 2003European Archives of Psychiatry and Clinical Neuroscience, 256
S. Lupien, C. Gillin, R. Hauger (1999)
Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans.Behavioral neuroscience, 113 3
Matthew Koshy, J. Villano, T. Dolecek, Andrew Howard, S. Chmura, R. Weichselbaum, Bridget McCarthy (2011)
Improved survival time trends for glioblastoma using the SEER 17 population-based registries.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 15_suppl
James Galle, M. McDonald, V. Simoneaux, J. Buchsbaum (2015)
Reirradiation with Proton Therapy for Recurrent Gliomas, 2
D. Osoba, G. Rodrigues, J. Myles, B. Zee, J. Pater (1998)
Interpreting the significance of changes in health-related quality-of-life scores.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16 1
M. Taphoorn, L. Claassens, N. Aaronson, C. Coens, M. Mauer, D. Osoba, R. Stupp, R. Mirimanoff, M. Bent, A. Bottomley (2010)
An international validation study of the EORTC brain cancer module (EORTC QLQ-BN20) for assessing health-related quality of life and symptoms in brain cancer patients.European journal of cancer, 46 6
S. Scoccianti, G. Francolini, G. Carta, D. Greto, B. Detti, G. Simontacchi, L. Visani, M. Baki, L. Poggesi, P. Bonomo, M. Mangoni, I. Desideri, S. Pallotta, L. Livi (2018)
Re-irradiation as salvage treatment in recurrent glioblastoma: A comprehensive literature review to provide practical answers to frequently asked questions.Critical reviews in oncology/hematology, 126
(2019)
2018c) Health related quality of life in large recurrence glioblastoma treated with active beam protontherapy
Team (2016) nlme: linear and nonlinear mixed effects models
C. Neider, U. Nestle, M. Niewald, K. Walter, K. Schnabel (1999)
Hyperfractionated reirradiation for malignant glioma.Frontiers of radiation therapy and oncology, 33
Claudia Bitterlich, D. Vordermark (2017)
Analysis of health-related quality of life in patients with brain tumors prior and subsequent to radiotherapy.Oncology letters, 14 2
S. Ryu, J. Buatti, A. Morris, S. Kalkanis, T. Ryken, J. Olson (2014)
The role of radiotherapy in the management of progressive glioblastomaJournal of Neuro-Oncology, 118
(2004)
Glioma Outcomes Project Investigators. Depression in patients with highgrade glioma: results of the Glioma Outcomes Project
M. Koshy, J. Villano, T. Dolecek, A. Howard, U. Mahmood, S. Chmura, R. Weichselbaum, B. McCarthy (2012)
Improved survival time trends for glioblastoma using the SEER 17 population-based registriesJournal of Neuro-Oncology, 107
P. Navarria, G. Minniti, E. Clerici, S. Tomatis, V. Pinzi, P. Ciammella, M. Galaverni, D. Amelio, D. Scartoni, S. Scoccianti, M. Krengli, L. Masini, L. Draghini, E. Maranzano, V. Borzillo, P. Muto, F. Ferrarese, L. Fariselli, L. Livi, F. Pasqualetti, A. Fiorentino, F. Alongi, M. Monale, S. Magrini, M. Scorsetti (2018)
Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter study of the Radiation Oncology Italian Association (AIRO)Journal of Neuro-Oncology, 142
A. Ernst-Stecken, O. Ganslandt, U. Lambrecht, R. Sauer, G. Grabenbauer (2007)
Survival and quality of life after hypofractionated stereotactic radiotherapy for recurrent malignant gliomaJournal of Neuro-Oncology, 81
D. Scartoni, D. Amelio, I. Giacomelli, M. Amichetti (2018)
P01.086 Health-Related Quality of Life in recurrent Glioblastoma treated with re-irradiation with active scanning ProtontherapyNeuro-Oncology
V. Preedy, R. Watson (2010)
European Organization for Research and Treatment of Cancer
(2012)
Radiation therapy for the treatment of recurrent glioblastoma: an overview. Cancers
Health related quality of life in patients with recurrence glioblastoma treated with active beam protontherapy
W. Wick, H. Fricke, K. Junge, G. Kobyakov, Tobias Martens, O. Heese, B. Wiestler, M. Schliesser, A. Deimling, J. Pichler, E. Vetlova, I. Harting, J. Debus, C. Hartmann, C. Kunz, M. Plattén, M. Bendszus, S. Combs (2014)
A Phase II, Randomized, Study of Weekly APG101+Reirradiation versus Reirradiation in Progressive GlioblastomaClinical Cancer Research, 20
G. Minniti, D. Amelio, M. Amichetti, M. Salvati, R. Muni, A. Bozzao, G. Lanzetta, S. Scarpino, A. Arcella, R. Enrici (2010)
Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 97 3
N. Litofsky, E. Farace, F. Anderson, C. Meyers, Wei Huang, E. Laws, Adam Kaplan, H. Brem, M. Berger, M. Westphal (2004)
Depression in Patients with High-grade Glioma: Results of the Glioma Outcomes ProjectNeurosurgery, 54
(2004)
Central Brain Tumor Registry of the United States (CBTRUS) (2010) Statistical report: primary brain and central nervous system tumors diagnosed in the United States in
(2018)
2018a) Health related quality of life
I. Aprile, S. Chiesa, L. Padua, C. Blasi, Maria Arezzo, V. Valentini, E. Stasio, M. Balducci (2015)
Occurrence and predictors of the fatigue in high-grade glioma patientsNeurological Sciences, 36
(2014)
AANS / CNS Joint Guidelines Committee the role of radiotherapy in the management of progressive glioblastoma : systematic review and evidence - based clinical practice guideline
D. Scartoni, D. Amelio, F. Fellin, I. Giacomelli, M. Schwarz, M. Amichetti (2019)
EP-1255 Health-Related Quality of Life in large recurrence Glioblastoma treated with protontherapyRadiotherapy and Oncology
Health related quality of life in large recurrence glioblastoma treated with active beam proton - therapy
A. Young, B. Sahakian, T. Robbins, P. Cowen (1999)
The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteersPsychopharmacology, 145
(2010)
Statistical report : primary brain and central nervous system tumors diagnosed in the United States in 2004 – 2007
C. Hahn, R. Dunn, P. Logue, J. King, C. Edwards, E. Halperin (2003)
Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors.International journal of radiation oncology, biology, physics, 55 4
F. Kazmi, Y. Soon, Y. Leong, W. Koh, B. Vellayappan (2018)
Re-irradiation for recurrent glioblastoma (GBM): a systematic review and meta-analysisJournal of Neuro-Oncology, 142
R. Team (2014)
R: A language and environment for statistical computing.MSOR connections, 1
(2010)
A (2010b) Review on quality of life issues in patients with primary brain tumors
N. Aaronson, S. Ahmedzai, B. Bergman, M. Bullinger, A. Cull, N. Duez, A. Filiberti, H. Flechtner, S. Fleishman, J. Haes, S. Kaasa, M. Klee, D. Osoba, D. Razavi, Peter Rofe, S. Schraub, K. Sneeuw, M. Sullivan, F. Takeda (1993)
The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.Journal of the National Cancer Institute, 85 5
D. Amelio, M. Amichetti (2012)
Radiation Therapy for the Treatment of Recurrent Glioblastoma: An OverviewCancers, 4
M. Taphoorn, R. Stupp, C. Coens, D. Osoba, R. Kortmann, M. Bent, W. Mason, R. Mirimanoff, B. Baumert, E. Eisenhauer, P. Forsyth, A. Bottomley (2005)
Health-related quality of life in patients with glioblastoma: a randomised controlled trial.The Lancet. Oncology, 6 12
(2016)
nlme : linear and nonlinear mixed effects models
G. Minniti, C. Scaringi, Alessandra Baldoni, G. Lanzetta, V. Sanctis, V. Esposito, R. Enrici (2013)
Health-related quality of life in elderly patients with newly diagnosed glioblastoma treated with short-course radiation therapy plus concomitant and adjuvant temozolomide.International journal of radiation oncology, biology, physics, 86 2
M. Walker, J. Brown, K. Brown, A. Gregor, I. Whittle, R. Grant (2003)
Practical problems with the collection and interpretation of serial quality of life assessments in patients with malignant gliomaJournal of Neuro-Oncology, 63
M. Mizumoto, T. Okumura, E. Ishikawa, Tetsuya Yamamoto, S. Takano, Akira Matsumura, Y. Oshiro, Hitoshi Ishikawa, Hideyuki Sakurai, K. Tsuboi (2013)
Reirradiation for recurrent malignant brain tumor with radiotherapy or proton beam therapyStrahlentherapie und Onkologie, 189
M. Taphoorn, E. Sizoo, A. Bottomley (2010)
Review on quality of life issues in patients with primary brain tumors.The oncologist, 15 6
PurposeProton therapy could minimize the risk of side effects and, therefore, reduce the possible detrimental effect on health-related quality of life (HRQOL) of re-irradiation. The aim of this study was to determine the effect of re-irradiation with active scanning proton therapy on recurrent glioblastoma (GBM) in terms of HRQOL scored by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 and EORTC Quality of Life Questionnaire Brain Cancer Module (QLQ-BN20).MethodsThirty-three patients with recurrent GBM were re-irradiated with active scanning proton therapy. Subscales within the EORTC QLQ-C30 include five functional scales, six single-item scales, and global QoL. The BN20 assessed visual disorders, motor function, communication deficit, various disease symptoms, treatment, toxicity, and future uncertainty. The patients completed the questionnaires before starting proton therapy, the last day of proton therapy, and at every follow-up visit until progression of disease.ResultsThe treatment was associated with improvement or stability in most of the preselected HRQOL domains. Global health improved over time with a maximum difference of six points between baseline and 3-months follow-up. Social functioning and motor dysfunction improved over time with a maximum difference of eight and two points, respectively. We showed a non-significant decrease in cognitive and emotional functioning. Fatigue remained stable during the analysis such as the other preselected domains.ConclusionsRe-irradiation with proton therapy is a safe and effective treatment in patients with recurrent glioblastoma. Proton therapy does not negatively effect on HRQOL, but rather it seems to preserve HRQOL until the time of disease progression.
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Mar 21, 2020
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