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Malignant pheochromocytoma: new malignancy criteria

Malignant pheochromocytoma: new malignancy criteria Langenbecks Arch Surg (2012) 397:239–246 DOI 10.1007/s00423-011-0850-3 ORIGINAL ARTICLE Pierre de Wailly & Luigi Oragano & Francois Radé & Anthony Beaulieu & Vincent Arnault & Pierre Levillain & Jean Louis Kraimps Received: 1 June 2011 /Accepted: 8 September 2011 /Published online: 9 November 2011 Springer-Verlag 2011 Abstract directly correlated to presence of TN (p<0.005) and Purpose The pathological diagnosis of malignancy in malignancy (G1 14.1%, G2 1.8%, G3 2.6%; p<0.001). pheochromocytomas remains a controversial issue. Accord- All G1 had a Ki-67 index >4%, although one G3 presented ing to the WHO, malignancy is defined in the presence of an 11% Ki-67 index. There was an inverse statistically metastasis. Multiparameter scoring systems such as PASS significant correlation between the three groups in staining (Pheochromocytoma of Adrenal gland Scaled Score) have using pS100 (p<0.01). been used but remain controversial. The aim of this study Conclusions Size and weight of the pheochromocytoma are was to search for new immunohistologic elements allowing directly related to PASS and malignancy. The presence of determination of pheochromocytoma malignancy. tumour necrosis, Ki-67 index >4% and pS100 absence Methods Among 53 patients operated for pheochromocy- impose a close histopathological evaluation and follow-up toma between 1993 and 2009, we http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Langenbeck's Archives of Surgery Springer Journals

Malignant pheochromocytoma: new malignancy criteria

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References (36)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Medicine & Public Health; Abdominal Surgery; General Surgery; Thoracic Surgery; Vascular Surgery; Cardiac Surgery; Traumatic Surgery
ISSN
1435-2443
eISSN
1435-2451
DOI
10.1007/s00423-011-0850-3
pmid
22069042
Publisher site
See Article on Publisher Site

Abstract

Langenbecks Arch Surg (2012) 397:239–246 DOI 10.1007/s00423-011-0850-3 ORIGINAL ARTICLE Pierre de Wailly & Luigi Oragano & Francois Radé & Anthony Beaulieu & Vincent Arnault & Pierre Levillain & Jean Louis Kraimps Received: 1 June 2011 /Accepted: 8 September 2011 /Published online: 9 November 2011 Springer-Verlag 2011 Abstract directly correlated to presence of TN (p<0.005) and Purpose The pathological diagnosis of malignancy in malignancy (G1 14.1%, G2 1.8%, G3 2.6%; p<0.001). pheochromocytomas remains a controversial issue. Accord- All G1 had a Ki-67 index >4%, although one G3 presented ing to the WHO, malignancy is defined in the presence of an 11% Ki-67 index. There was an inverse statistically metastasis. Multiparameter scoring systems such as PASS significant correlation between the three groups in staining (Pheochromocytoma of Adrenal gland Scaled Score) have using pS100 (p<0.01). been used but remain controversial. The aim of this study Conclusions Size and weight of the pheochromocytoma are was to search for new immunohistologic elements allowing directly related to PASS and malignancy. The presence of determination of pheochromocytoma malignancy. tumour necrosis, Ki-67 index >4% and pS100 absence Methods Among 53 patients operated for pheochromocy- impose a close histopathological evaluation and follow-up toma between 1993 and 2009, we

Journal

Langenbeck's Archives of Surgery – Springer Journals

Published: Nov 9, 2011

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