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- Publisher
- Springer Journals
- Copyright
- Copyright © 2012 by Springer-Verlag Berlin Heidelberg
- Subject
- Biomedicine; Psychiatry; Neurosciences; Pharmacology/Toxicology
- ISSN
- 0033-3158
- eISSN
- 1432-2072
- DOI
- 10.1007/s00213-012-2761-6
- pmid
- 22700038
- Publisher site
- See Article on Publisher Site
Abstract
The MDMA-induced prolongation of the latency to and reduction of light-induced miosis indicate indirect central parasympathetic inhibition, and the faster recovery time reflects an increased sympathomimetic action. Both norepinephrine and serotonin mediate the effects of MDMA on pupillary function. Although mydriasis is lasting and mirrors the plasma concentration–time curve of MDMA, the impairment in the reaction to light is associated with the subjective and other autonomic effects of MDMA and exhibits acute tolerance.
Journal
Psychopharmacology – Springer Journals
Published: Dec 1, 2012