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Maternal serum insulin‐like growth factor‐I at 11–13 weeks in preeclampsia

Maternal serum insulin‐like growth factor‐I at 11–13 weeks in preeclampsia Objective To investigate the maternal serum concentration of insulin‐like growth factor‐I (IGF‐I) in the first trimester of pregnancies that subsequently develop preeclampsia (PE) and to examine the possible association with uterine artery pulsatility index (PI). Methods The maternal serum concentration of IGF‐I and uterine artery PI at 11–13 weeks were measured in 53 cases that developed PE, including 18 that required delivery before 34 weeks (early‐PE) and 106 unaffected controls. The measured IGF‐I concentration and uterine artery PI were converted into a multiple of the expected median (MoM) in unaffected pregnancies, and median MoM values were compared in the outcome groups. The significance of association of IGF‐I MoM with uterine artery PI MoM was determined by regression analysis. Results In the early‐PE and late‐PE groups, compared to the unaffected controls, the median IGF‐I decreased (0.53 and 0.55 MoM, respectively) and uterine artery PI increased (1.55 and 1.21 MoM, respectively). In the group that developed PE, there was no significant association between serum IGF‐I and uterine artery PI (p = 0.632). Conclusion In pregnancies destined to develop PE, the circulating levels of IGF‐I decrease from the first trimester of pregnancy suggesting that IGF‐I may be implicated in the pathogenesis of the disease. Copyright © 2010 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Prenatal Diagnosis Wiley

Maternal serum insulin‐like growth factor‐I at 11–13 weeks in preeclampsia

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References (47)

Publisher
Wiley
Copyright
Copyright © 2010 John Wiley & Sons, Ltd.
ISSN
0197-3851
eISSN
1097-0223
DOI
10.1002/pd.2555
pmid
20865795
Publisher site
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Abstract

Objective To investigate the maternal serum concentration of insulin‐like growth factor‐I (IGF‐I) in the first trimester of pregnancies that subsequently develop preeclampsia (PE) and to examine the possible association with uterine artery pulsatility index (PI). Methods The maternal serum concentration of IGF‐I and uterine artery PI at 11–13 weeks were measured in 53 cases that developed PE, including 18 that required delivery before 34 weeks (early‐PE) and 106 unaffected controls. The measured IGF‐I concentration and uterine artery PI were converted into a multiple of the expected median (MoM) in unaffected pregnancies, and median MoM values were compared in the outcome groups. The significance of association of IGF‐I MoM with uterine artery PI MoM was determined by regression analysis. Results In the early‐PE and late‐PE groups, compared to the unaffected controls, the median IGF‐I decreased (0.53 and 0.55 MoM, respectively) and uterine artery PI increased (1.55 and 1.21 MoM, respectively). In the group that developed PE, there was no significant association between serum IGF‐I and uterine artery PI (p = 0.632). Conclusion In pregnancies destined to develop PE, the circulating levels of IGF‐I decrease from the first trimester of pregnancy suggesting that IGF‐I may be implicated in the pathogenesis of the disease. Copyright © 2010 John Wiley & Sons, Ltd.

Journal

Prenatal Diagnosis – Wiley

Published: Nov 1, 2010

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