Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cre/lox‐controlled spatiotemporal perturbation of FGF signaling in zebrafish

Cre/lox‐controlled spatiotemporal perturbation of FGF signaling in zebrafish Background: Spatiotemporal perturbation of signaling pathways in vivo remains challenging and requires precise transgenic control of signaling effectors. Fibroblast growth factor (FGF) signaling guides multiple developmental processes, including body axis formation and cell fate patterning. In zebrafish, mutants and chemical perturbations affecting FGF signaling have uncovered key developmental processes; however, these approaches cause embryo‐wide perturbations, rendering assessment of cell‐autonomous vs. non‐autonomous requirements for FGF signaling in individual processes difficult. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Dynamics Wiley

Cre/lox‐controlled spatiotemporal perturbation of FGF signaling in zebrafish

Loading next page...
 
/lp/wiley/cre-lox-controlled-spatiotemporal-perturbation-of-fgf-signaling-in-ii0Op8kwEx

References (82)

Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1058-8388
eISSN
1097-0177
DOI
10.1002/dvdy.24668
Publisher site
See Article on Publisher Site

Abstract

Background: Spatiotemporal perturbation of signaling pathways in vivo remains challenging and requires precise transgenic control of signaling effectors. Fibroblast growth factor (FGF) signaling guides multiple developmental processes, including body axis formation and cell fate patterning. In zebrafish, mutants and chemical perturbations affecting FGF signaling have uncovered key developmental processes; however, these approaches cause embryo‐wide perturbations, rendering assessment of cell‐autonomous vs. non‐autonomous requirements for FGF signaling in individual processes difficult.

Journal

Developmental DynamicsWiley

Published: Oct 1, 2018

Keywords: ; ;

There are no references for this article.