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- Publisher
- American Medical Association
- Copyright
- Copyright 2021 American Medical Association. All Rights Reserved.
- ISSN
- 2168-622X
- eISSN
- 2168-6238
- DOI
- 10.1001/jamapsychiatry.2021.1256
- Publisher site
- See Article on Publisher Site
Abstract
Opinion EDITORIAL Changes in Attributable Fractions and Causal Inference for Schizophrenia and Other Psychiatric Outcomes Tyler J. VanderWeele, PhD In this issue of JAMA Psychiatry, Hjorthøj et al use Danish ing the increasing incidence, and as I will discuss, this may be national registry data from 1972 through 2016 to examine lon- the case here. As noted above, the authors gitudinal associations between cannabis use disorder and report, from 1972 through schizophrenia after controlling for potential confounders. They 2016, an increase in the schizophrenia population attribut- carried out numerous sensi- able risk fraction (PARF) for cannabis use disorder from 2% 2 1 tivity analyses and further to 8%. They note that this is “what would be expected.” Related article page 1013 report attributable fractions However, this increase in PARF does not itself constitute for schizophrenia attributable to cannabis use disorder. The a distinct source of evidence for causality. The PARF is article makes 2 distinct contributions. First, it adds to the prior a deterministic function of the rate ratio (RR) and the preva- 3,4 evidence base concerning potential associations of canna- lence of cannabis use disorder among individuals with bis use with schizophrenia, with analyses indicating a rela- schizophrenia.
Journal
JAMA Psychiatry – American Medical Association
Published: Sep 21, 2021