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Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks... Key PointsQuestionAre longitudinal trends in insulin levels and body mass index from childhood associated with adult depression and psychosis? FindingsThis cohort study of repeated-measure data from age 1 to 24 years in up to 10 463 individuals identified trajectories of fasting insulin levels and body mass index. Persistently high fasting insulin levels from age 9 years were associated with psychosis at 24 years, and puberty-onset body mass index increase was associated with depression at 24 years. MeaningThis study’s findings suggest that changes in insulin sensitivity and adiposity starting from childhood may have disorder-specific associations with psychosis and depression and represent targets for prevention and treatment of cardiometabolic disorders in people with psychosis and depression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults

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References (116)

Publisher
American Medical Association
Copyright
Copyright 2021 Perry BI et al. JAMA Psychiatry.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2020.4180
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionAre longitudinal trends in insulin levels and body mass index from childhood associated with adult depression and psychosis? FindingsThis cohort study of repeated-measure data from age 1 to 24 years in up to 10 463 individuals identified trajectories of fasting insulin levels and body mass index. Persistently high fasting insulin levels from age 9 years were associated with psychosis at 24 years, and puberty-onset body mass index increase was associated with depression at 24 years. MeaningThis study’s findings suggest that changes in insulin sensitivity and adiposity starting from childhood may have disorder-specific associations with psychosis and depression and represent targets for prevention and treatment of cardiometabolic disorders in people with psychosis and depression.

Journal

JAMA PsychiatryAmerican Medical Association

Published: Apr 13, 2021

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