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Key PointsQuestionAre longitudinal trends in insulin levels and body mass index from childhood associated with adult depression and psychosis? FindingsThis cohort study of repeated-measure data from age 1 to 24 years in up to 10 463 individuals identified trajectories of fasting insulin levels and body mass index. Persistently high fasting insulin levels from age 9 years were associated with psychosis at 24 years, and puberty-onset body mass index increase was associated with depression at 24 years. MeaningThis study’s findings suggest that changes in insulin sensitivity and adiposity starting from childhood may have disorder-specific associations with psychosis and depression and represent targets for prevention and treatment of cardiometabolic disorders in people with psychosis and depression.
JAMA Psychiatry – American Medical Association
Published: Apr 13, 2021
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