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Key PointsQuestionIs frequent or heavy cannabis use associated with cognitive dysfunction in adolescents and young adults? FindingsThis systematic review and meta-analysis of 69 cross-sectional studies of 2152 cannabis users and 6575 comparison participants showed a small but significant overall effect size for reduced cognitive functioning in adolescents and young adults who reported frequent cannabis use. However, studies requiring abstinence from cannabis for longer than 72 hours had a very small, nonsignificant effect size. MeaningAlthough continued cannabis use may be associated with small reductions in cognitive functioning, results suggest that cognitive deficits are substantially diminished with abstinence.
JAMA Psychiatry – American Medical Association
Published: Jun 18, 2018
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