Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Joffe, Laura Petrillo, A. Koukopoulos, A. Viguera, April Hirschberg, R. Nonacs, B. Somley, Erica Pasciullo, D. White, J. Hall, L. Cohen (2011)
Increased estradiol and improved sleep, but not hot flashes, predict enhanced mood during the menopausal transition.The Journal of clinical endocrinology and metabolism, 96 7
J. Greene (1998)
Constructing a standard climacteric scale.Maturitas, 29 1
N. Watson, J. Studd, A. Riddle, M. Savvas (1988)
Suppression of ovulation by transdermal oestradiol patches.British Medical Journal, 297
D. Rubinow, S. Girdler (2011)
Hormones, heart disease, and health: individualized medicine versus throwing the baby out with the bathwaterDepression and Anxiety, 28
J. Gordon, D. Rubinow, T. Eisenlohr-Moul, J. Leserman, S. Girdler (2016)
Estradiol variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transitionMenopause, 23
C. Gleason, N. Dowling, W. Wharton, J. Manson, V. Miller, C. Atwood, E. Brinton, M. Cedars, R. Lobo, G. Merriam, G. Neal-Perry, N. Santoro, H. Taylor, D. Black, M. Budoff, H. Hodis, F. Naftolin, S. Harman, S. Asthana (2015)
Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS–Cognitive and Affective StudyPLoS Medicine, 12
T. Eisenlohr-Moul, D. Rubinow, C. Schiller, Jacqueline Johnson, J. Leserman, S. Girdler (2016)
Histories of abuse predict stronger within-person covariation of ovarian steroids and mood symptoms in women with menstrually related mood disorderPsychoneuroendocrinology, 67
J. Bromberger, H. Kravitz, Yuefang Chang, J. Cyranowski, Charlotte Brown, K. Matthews (2011)
Major depression during and after the menopausal transition: Study of Women's Health Across the Nation (SWAN)Psychological Medicine, 41
I. Sarason, James Johnson (1976)
The Life Experiences Survey: Preliminary Findings
Jeff Boyd, Myrna Weissman, W. Thompson, Jerome Myers (1982)
Screening for depression in a community sample. Understanding the discrepancies between depression symptom and diagnostic scales.Archives of general psychiatry, 39 10
P. Schmidt, L. Nieman, M. Danaceau, M. Tobin, C. Roca, Jean Murphy, D. Rubinow (2000)
Estrogen replacement in perimenopause-related depression: a preliminary report.American journal of obstetrics and gynecology, 183 2
C. Soares, Helga Arsenio, H. Joffe, B. Bankier, P. Cassano, Laura Petrillo, L. Cohen (2006)
Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of lifeMenopause, 13
J. Leserman, D. Drossman, Zhiming Li (1995)
The reliability and validity of a sexual and physical abuse history questionnaire in female patients with gastrointestinal disorders.Behavioral medicine, 21 3
S. Harlow, Margery Gass, J. Hall, R. Lobo, P. Maki, R. Rebar, Sherry Sherman, P. Sluss, T. Villiers (2012)
Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive agingClimacteric, 15
LS Radloff (1977)
The CES-D scale a self-report depression scale for research in the general population, 1
N. Woods, K. Smith-Dijulio, D. Percival, E. Tao, A. Mariella, E. Mitchell (2008)
Depressed mood during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women's Health StudyMenopause, 15
C. Stuenkel, Margery Gass, J. Manson, R. Lobo, L. Pal, R. Rebar, J. Hall (2012)
A decade after the women's health initiative--the experts do agree.The Journal of clinical endocrinology and metabolism, 97 8
J. Gordon, S. Girdler, S. Meltzer-Brody, C. Stika, R. Thurston, C. Clark, B. Prairie, E. Moses-Kolko, H. Joffe, K. Wisner (2015)
Ovarian hormone fluctuation, neurosteroids, and HPA axis dysregulation in perimenopausal depression: a novel heuristic model.The American journal of psychiatry, 172 3
L. Cohen, C. Soares, A. Vitonis, M. Otto, B. Harlow (2006)
Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles.Archives of general psychiatry, 63 4
E. Freeman, M. Sammel, Li Liu, C. Gracia, D. Nelson, Lori Hollander (2004)
Hormones and menopausal status as predictors of depression in women in transition to menopause.Archives of general psychiatry, 61 1
J. Thomas, Glenn Jones, I. Scarinci, D. Mehan, P. Brantley (2001)
The Utility of the Ces-D as a Depression Screening Measure among Low-Income Women Attending Primary Care ClinicsThe International Journal of Psychiatry in Medicine, 31
N. Santoro, J. Randolph (2011)
Reproductive hormones and the menopause transition.Obstetrics and gynecology clinics of North America, 38 3
J. Leserman, Zhiming Li, D. Drossman, T. Toomey, G. Nachman, Louise Glogau (1997)
Impact of Sexual and Physical Abuse Dimensions on Health Status: Development of an Abuse Severity MeasurePsychosomatic Medicine, 59
G. Hale, H. Burger (2009)
Hormonal changes and biomarkers in late reproductive age, menopausal transition and menopause.Best practice & research. Clinical obstetrics & gynaecology, 23 1
J. Rossouw, G. Anderson, Ross Prentice, Andrea LaCroix, C. Kooperberg, M. Stefanick, R. Jackson, Shirley Beresford, Barbara Howard, Karen Johnson, J. Kotchen, Judith Ockene (2002)
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.JAMA, 288 3
J. Bromberger, K. Matthews, Laura Schott, Sarah Brockwell, N. Avis, H. Kravitz, Susan Everson‐Rose, E. Gold, M. Sowers, J. Randolph (2007)
Depressive symptoms during the menopausal transition: the Study of Women's Health Across the Nation (SWAN).Journal of affective disorders, 103 1-3
I. Sarason, James Johnson, J. Siegel (1978)
Assessing the impact of life changes: development of the Life Experiences Survey.Journal of consulting and clinical psychology, 46 5
G. Hale, C. Shufelt (2015)
Hormone therapy in menopause: An update on cardiovascular disease considerations.Trends in cardiovascular medicine, 25 6
J. Leserman, J. Petitto, H. Gu, B. Gaynes, J. Barroso, R. Golden, D. Perkins, J. Folds, Dwight Evans (2002)
Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictorsPsychological Medicine, 32
J. Leserman, D. Drossman, Zhiming Li, T. Toomey, G. Nachman, Louise Glogau (1996)
Sexual and Physical Abuse History in Gastroenterology Practice: How Types of Abuse Impact Health StatusPsychosomatic Medicine, 58
L. Radloff (1977)
The CES-D ScaleApplied Psychological Measurement, 1
S. Girdler, J. Leserman, R. Bunevic̆ius, Rebecca Klatzkin, C. Pedersen, K. Light (2007)
Persistent alterations in biological profiles in women with abuse histories: influence of premenstrual dysphoric disorder.Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 26 2
J. Leserman, J. Petitto, D. Perkins, J. Folds, R. Golden, Dwight Evans (1997)
Severe stress, depressive symptoms, and changes in lymphocyte subsets in human immunodeficiency virus-infected men. A 2-year follow-up study.Archives of general psychiatry, 54 3
N. Avis, D. Brambilla, S. Mckinlay, K. Vass (1994)
A longitudinal analysis of the association between menopause and depression. Results from the Massachusetts Women's Health Study.Annals of epidemiology, 4 3
P. Schmidt, Rivka Dor, P. Martinez, Gioia Guerrieri, Veronica Harsh, Karla Thompson, D. Koziol, L. Nieman, D. Rubinow (2015)
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.JAMA psychiatry, 72 7
J. Leserman, G. Ironson, C. O’Cleirigh, J. Fordiani, E. Balbin (2008)
Stressful life events and adherence in HIV.AIDS patient care and STDs, 22 5
H. Burger, G. Hale, D. Robertson, L. Dennerstein (2007)
A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women's Midlife Health Project.Human reproduction update, 13 6
Key PointsQuestionIs 12 months of transdermal estradiol and intermittent micronized progesterone more effective than placebo in preventing the development of depressive symptoms in the menopause transition and early postmenopausal period? FindingsIn this randomized clinical trial that included 172 perimenopausal and early postmenopausal women, 32.3% of women receiving placebo developed clinically significant depressive symptoms, while 17.3% of women taking transdermal estradiol and intermittent micronized progesterone did so. MeaningIf confirmed in future research, clinicians may consider prescribing hormone therapy to mitigate the increased risk of clinically significant depressive symptoms that accompany the menopause transition and early postmenopausal period.
JAMA Psychiatry – American Medical Association
Published: Feb 10, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.