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Leveraging Molecular Genetic Approaches to Yield Insights Into Major Depression Etiology and Clinical Presentation

Leveraging Molecular Genetic Approaches to Yield Insights Into Major Depression Etiology and... Opinion EDITORIAL Leveraging Molecular Genetic Approaches to Yield Insights Into Major Depression Etiology and Clinical Presentation Roseann E. Peterson, PhD Major depressive disorder (MDD) is an important public MDD with obesity-related traits. Patients were stratified into 3 groups, according to their endorsement of the atypical de- health concern and is often comorbid with other serious medical conditions, such as obesity, cardiovascular disease, pression symptom of increased weight/appetite, decreased and type 2 diabetes. Notably, several symptoms of MDD are weight/appetite, and no change on weight/appetite. The re- related to energy balance, searchers applied 3 molecular genetic approaches to illus- including disturbances in trate differences in genetic risk profiles between these clini- Related article weight, appetite, and sleep. cal subgroups. These methods are reviewed in the context of Genetic factors have consistently been demonstrated to influ- the main findings of Milaneschi et al, and more generally with ence individual differences in MDD and body mass index respect to analytical approaches for parsing complex trait (BMI; calculated as weight in kilograms divided by height in heterogeneity. meters squared), with twin studies estimating heritabilities First, estimates of h are reported for MDD subgroups, using 2 2,3 (h ) on the order of 0.37 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Leveraging Molecular Genetic Approaches to Yield Insights Into Major Depression Etiology and Clinical Presentation

Peterson, Roseann E.
JAMA Psychiatry , Volume 74 (12) – Dec 18, 2017
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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2017.3017
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Leveraging Molecular Genetic Approaches to Yield Insights Into Major Depression Etiology and Clinical Presentation Roseann E. Peterson, PhD Major depressive disorder (MDD) is an important public MDD with obesity-related traits. Patients were stratified into 3 groups, according to their endorsement of the atypical de- health concern and is often comorbid with other serious medical conditions, such as obesity, cardiovascular disease, pression symptom of increased weight/appetite, decreased and type 2 diabetes. Notably, several symptoms of MDD are weight/appetite, and no change on weight/appetite. The re- related to energy balance, searchers applied 3 molecular genetic approaches to illus- including disturbances in trate differences in genetic risk profiles between these clini- Related article weight, appetite, and sleep. cal subgroups. These methods are reviewed in the context of Genetic factors have consistently been demonstrated to influ- the main findings of Milaneschi et al, and more generally with ence individual differences in MDD and body mass index respect to analytical approaches for parsing complex trait (BMI; calculated as weight in kilograms divided by height in heterogeneity. meters squared), with twin studies estimating heritabilities First, estimates of h are reported for MDD subgroups, using 2 2,3 (h ) on the order of 0.37

Journal

JAMA Psychiatry – American Medical Association

Published: Dec 18, 2017

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