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Higher Cortical Amyloid Burden and Loneliness in Older Adults Original Investigation Research in Alzheimer’s disease: current landscape, novel 61. Valla J, Yaari R, Wolf AB, et al. Reduced 63. Wang C, Wilson WA, Moore SD, et al. Human data, and future perspective. J Neurochem. 2015; posterior cingulate mitochondrial activity in expired apoE4-targeted replacement mice display synaptic 133(4):465-488. young adult carriers of the APOE ε4 allele, the deficits in the absence of neuropathology. major late-onset Alzheimer’s susceptibility gene. Neurobiol Dis. 2005;18(2):390-398. 60. Reiman EM, Chen K, Alexander GE, et al. J Alzheimers Dis. 2010;22(1):307-313. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. 62. Nathan BP, Bellosta S, Sanan DA, Weisgraber Proc Natl Acad SciUSA. 2004;101(1):284-289. KH, Mahley RW, Pitas RE. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science. 1994;264(5160):850-852. Invited Commentary Loneliness as a Marker of Brain Amyloid Burden and Preclinical Alzheimer Disease Paul B. Rosenberg, MD Treatment development in Alzheimer disease (AD) has been ciated with depression. Instead, the authors hypothesize that systematically moving to earlier stages of disease to target pro- loneliness may be a specific symptom or construct related to dromal and even preclinical stages of AD,
JAMA Psychiatry – American Medical Association
Published: Dec 2, 2016
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