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Ascertaining Whether Suicides Are Caused by Infections

Ascertaining Whether Suicides Are Caused by Infections Opinion EDITORIAL Lena C. Brundin, MD, PhD; Jamie Grit, BSc Mounting evidence points to an up-regulated inflammatory fluid, and brains of depressed and suicidal individuals. For ex- response in patients who experience suicidal ideation, at- ample, elevated levels of interleukin 6 (IL-6) and the inflam- tempt, or commit suicide. Translational and clinical studies are matory metabolite quinolinic acid have been found in the ce- 5,6 now disentangling the neurobiological mechanisms that gen- rebrospinal fluid of persons recently attempting suicide. A erate the symptoms in inflam- recent meta-analysis concluded that increased IL-6 and IL-1β mation-induced depression. levels are most robustly associated with increased suicidal- Related article page 912 But what are the actual causes ity. It is of particular interest to the study by Lund-Sørensen of the low-grade, long-term et al that messenger RNA and protein levels of Toll-like re- inflammation that is observed in the patients? The triggers and ceptors (TLRs) 3 and 4 are up-regulated in the prefrontal cor- root causes of this enigmatic inflammation are not yet well tex of individuals who died by suicide. Toll-like receptors have studied. In this issue of JAMA Psychiatry, Lund-Sørensen et a key role in the innate immune response to infections. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Ascertaining Whether Suicides Are Caused by Infections

Brundin, Lena C.; Grit, Jamie
JAMA Psychiatry , Volume 73 (9) – Sep 10, 2016
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References (15)

Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2016.1470
pmid
27533721
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Lena C. Brundin, MD, PhD; Jamie Grit, BSc Mounting evidence points to an up-regulated inflammatory fluid, and brains of depressed and suicidal individuals. For ex- response in patients who experience suicidal ideation, at- ample, elevated levels of interleukin 6 (IL-6) and the inflam- tempt, or commit suicide. Translational and clinical studies are matory metabolite quinolinic acid have been found in the ce- 5,6 now disentangling the neurobiological mechanisms that gen- rebrospinal fluid of persons recently attempting suicide. A erate the symptoms in inflam- recent meta-analysis concluded that increased IL-6 and IL-1β mation-induced depression. levels are most robustly associated with increased suicidal- Related article page 912 But what are the actual causes ity. It is of particular interest to the study by Lund-Sørensen of the low-grade, long-term et al that messenger RNA and protein levels of Toll-like re- inflammation that is observed in the patients? The triggers and ceptors (TLRs) 3 and 4 are up-regulated in the prefrontal cor- root causes of this enigmatic inflammation are not yet well tex of individuals who died by suicide. Toll-like receptors have studied. In this issue of JAMA Psychiatry, Lund-Sørensen et a key role in the innate immune response to infections.

Journal

JAMA Psychiatry – American Medical Association

Published: Sep 10, 2016

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