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Toward Understanding the Functional Relevance of White Matter Deficits in Bipolar Disorder

Toward Understanding the Functional Relevance of White Matter Deficits in Bipolar Disorder Opinion Editorial adolescence. At the same time, because only that component using enrichment strategies, such as the clinical high-risk of the variation in test scores that is age related is included in the design, population-based studies have a unique contribu- metric, this approach may underestimate the differences be- tion in helping to establish the generalizability of such indi- tween the groups to the extent that factors other than age influ- cators to cases ascertained independently of psychiatric ence the distributions. An approach that would allow all of the treatment contacts. While the value of the Gur et al report sources of neurocognitive test performance to influence the dif- is primarily in relation to the generalizability issue at this ferences between TD and PS would be to standardize the test point, with longitudinal follow-up of the cohort, it will scores within each age band and plot the mean differences be- become possible to test whether early indicators, such as tween cases and control participants across age bands. neurocognitive dysfunction, predict and deteriorate in asso- The field of psychosis research is rapidly expanding. ciation with onset of full psychosis among those with sub- Although most research on early indicators has been http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Toward Understanding the Functional Relevance of White Matter Deficits in Bipolar Disorder

Cullen, Kathryn R.; Lim, Kelvin O.
JAMA Psychiatry , Volume 71 (4) – Apr 1, 2014
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References (9)

Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2013.4638
pmid
24522794
Publisher site
See Article on Publisher Site

Abstract

Opinion Editorial adolescence. At the same time, because only that component using enrichment strategies, such as the clinical high-risk of the variation in test scores that is age related is included in the design, population-based studies have a unique contribu- metric, this approach may underestimate the differences be- tion in helping to establish the generalizability of such indi- tween the groups to the extent that factors other than age influ- cators to cases ascertained independently of psychiatric ence the distributions. An approach that would allow all of the treatment contacts. While the value of the Gur et al report sources of neurocognitive test performance to influence the dif- is primarily in relation to the generalizability issue at this ferences between TD and PS would be to standardize the test point, with longitudinal follow-up of the cohort, it will scores within each age band and plot the mean differences be- become possible to test whether early indicators, such as tween cases and control participants across age bands. neurocognitive dysfunction, predict and deteriorate in asso- The field of psychosis research is rapidly expanding. ciation with onset of full psychosis among those with sub- Although most research on early indicators has been

Journal

JAMA Psychiatry – American Medical Association

Published: Apr 1, 2014

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