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R. Wilson, G. Hoganson, K. Rajan, L. Barnes, C. Leon, Denis Evans (2010)
Temporal course of depressive symptoms during the development of Alzheimer diseaseNeurology, 75
D. Bennett, J. Schneider, A. Buchman, L. Barnes, P. Boyle, R. Wilson (2012)
Overview and findings from the rush Memory and Aging Project.Current Alzheimer research, 9 6
Meng-Yang Zhu, V. Klimek, G. Dilley, J. Haycock, C. Stockmeier, J. Overholser, H. Meltzer, G. Ordway (1999)
Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depressionBiological Psychiatry, 46
R. Zweig, C. Ross, J. Hedreen, C. Steele, Joseptemberh Cardillo, P. Whitehouse, Marchshal Folstein, D. Price (1988)
The neuropathology of aminergic nuclei in Alzheimer's diseaseAnnals of Neurology, 24
M. Bruce, T. Seeman, S. Merrill, D. Blazer (1994)
The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging.American journal of public health, 84 11
A. Syed, Mark Chatfield, F. Matthews, P. Harrison, C. Brayne, M. Esiri (2005)
Depression in the elderly: pathological study of raphe and locus ceruleusNeuropathology and Applied Neurobiology, 31
H. Braak, K. Tredici, U. Rüb, R. Vos, Ernst Steur, E. Braak (2003)
Staging of brain pathology related to sporadic Parkinson’s diseaseNeurobiology of Aging, 24
R. Wilson, S. Arnold, T. Beck, J. Bienias, D. Bennett (2008)
Change in depressive symptoms during the prodromal phase of Alzheimer disease.Archives of general psychiatry, 65 4
G. Zubenko, J. Moossy (1988)
Major depression in primary dementia. Clinical and neuropathologic correlates.Archives of neurology, 45 11
Stuart Hameroff, Randall Cork, J. Weiss, B. Crago, Thomas Davis (1984)
Doxepin's effects on chronic pain and depression: a controlled study.The Journal of clinical psychiatry, 45 3 Pt 2
L. Tremblay, C. Naranjo, S. Graham, N. Herrmann, H. Mayberg, S. Hevenor, U. Busto (2005)
Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe.Archives of general psychiatry, 62 11
P. Barone, W. Poewe, S. Albrecht, C. Debieuvre, D. Massey, O. Rascol, E. Tolosa, D. Weintraub (2010)
Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trialThe Lancet Neurology, 9
A. Rush, M. Trivedi, S. Wisniewski, J. Stewart, A. Nierenberg, M. Thase, Louise Ritz, M. Biggs, D. Warden, J. Luther, K. Shores‐Wilson, G. Niederehe, M. Fava (2006)
Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.The New England journal of medicine, 354 12
A. Beekman, J. Copeland, M. Prince (1999)
Review of community prevalence of depression in later lifeBritish Journal of Psychiatry, 174
B. Baumann, H. Bielau, D. Krell, Marcus Agelink, S. Diekmann, C. Wurthmann, K. Trübner, H. Bernstein, P. Danos, B. Bogerts (2002)
Circumscribed numerical deficit of dorsal raphe neurons in mood disordersPsychological Medicine, 32
S. Ikemoto (2007)
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complexBrain Research Reviews, 56
J. Schneider, Jia-liang Li, Yan Li, R. Wilson, J. Kordower, David Bennett (2006)
Substantia nigra tangles are related to gait impairment in older personsAnnals of Neurology, 59
D. Bennett, K. Shannon, Laurel Beckett, C. Goetz, R. Wilson (1997)
Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating ScaleNeurology, 49
T. Gos, D. Krell, H. Bielau, R. Brisch, K. Trübner, J. Steiner, H. Bernstein, Z. Jankowski, B. Bogerts (2008)
Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patientsEuropean Archives of Psychiatry and Clinical Neuroscience, 258
R. Wilson, J. Schneider, J. Bienias, Denis Evans, D. Bennett (2003)
Parkinsonianlike signs and risk of incident Alzheimer disease in older persons.Archives of neurology, 60 4
JP Feighner, CH Merideth, JL Claghorn (1984)
Multicenter placebo-controlled evaluation of nomifensine treatment in depressed outpatients., 45
M. Underwood, Alfia Khaibulina, S. Ellis, Andrew Moran, P. Rice, J. Mann, V. Arango (1999)
Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victimsBiological Psychiatry, 46
S. Fahn, R. Elton, C. Marsden, D. Calne, M. Goldstein (1986)
Recent Developments in Parkinson's Disease
D. Aarsland, Sven Påhlhagen, C. Ballard, U. Ehrt, P. Svenningsson (2011)
Depression in Parkinson disease—epidemiology, mechanisms and managementNature Reviews Neurology, 8
D. Gilley, R. Wilson, D. Fleischman, D. Harrison, C. Goetz, C. Tanner (1995)
Impact of Alzheimer's-type dementia and information source on the assessment of depressionPsychological Assessment, 7
Hans Förstl, A. Burns, P. Luthert, N. Cairns, P. Lantos, R. Levy (1992)
Clinical and neuropathological correlates of depression in Alzheimer's diseasePsychological Medicine, 22
D. Devanand, M. Sano, M. Tang, Stuart Taylor, B. Gurland, D. Wilder, Y. Stern, R. Mayeux (1996)
Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community.Archives of general psychiatry, 53 2
S. Fahn (1987)
Unified Parkinson's Disease Rating Scale, 2
B. Baumann, P. Danos, S. Diekmann, D. Krell, H. Bielau, C. Geretsegger, C. Wurthmann, H. Bernstein, B. Bogerts (1999)
Tyrosine hydroxylase immunoreactivity in the locus coeruleus is reduced in depressed non-suicidal patients but normal in depressed suicide patientsEuropean Archives of Psychiatry and Clinical Neuroscience, 249
F. Kohout, L. Berkman, Denis Evans, J. Cornoni-Huntley (1993)
Two Shorter Forms of the CES-D Depression Symptoms IndexJournal of Aging and Health, 5
G. Mckhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E. Stadlan (1984)
Clinical diagnosis of Alzheimer's diseaseNeurology, 34
K. Matthews, Christopher Chen, M. Esiri, J. Keene, S. Minger, P. Francis (2002)
Noradrenergic changes, aggressive behavior, and cognition in patients with dementiaBiological Psychiatry, 51
R. Wilson, S. Leurgans, P. Boyle, J. Schneider, David Bennett (2010)
Neurodegenerative basis of age-related cognitive declineNeurology, 75
D. Bennett, R. Wilson, J. Schneider, J. Bienias, S. Arnold (2004)
Cerebral infarctions and the relationship of depression symptoms to level of cognitive functioning in older persons.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 12 2
FJ Kohout, LF Berkman, DA Evans, J Cornoni-Huntley (1993)
Two shorter forms of the CES-D (Center for Epidemiological Studies Depression) depression symptoms index., 5
B. Schott, L. Minuzzi, R. Krebs, D. Elmenhorst, Markus Lang, O. Winz, C. Seidenbecher, H. Coenen, H. Heinze, K. Zilles, E. Düzel, A. Bauer (2008)
Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine ReleaseThe Journal of Neuroscience, 28
R. Wilson, L. Barnes, C. Leon, N. Aggarwal, J. Schneider, J. Bach, J. Piłat, Laurel Beckett, Laurel Beckett, S. Arnold, Denis Evans, D. Bennett (2002)
Depressive symptoms, cognitive decline, and risk of AD in older personsNeurology, 59
H. Manji, W. Drevets, D. Charney (2001)
The cellular neurobiology of depressionNature Medicine, 7
LS Radloff (1977)
The CES-D Scale: a self-report depression scale for research in the general population., 1
D. Bennett, R. Wilson, J. Schneider, Denis Evans, Laurel Beckett, N. Aggarwal, L. Barnes, J. Fox, J. Bach (2002)
Natural history of mild cognitive impairment in older personsNeurology, 59
R. Wilson, S. Nag, P. Boyle, L. Hizel, Lei Yu, A. Buchman, J. Schneider, D. Bennett (2013)
Neural reserve, neuronal density in the locus ceruleus, and cognitive declineNeurology, 80
D. Gilley, R. Wilson (1997)
Criterion-related validity of the Geriatric Depression Scale in Alzheimer's disease.Journal of clinical and experimental neuropsychology, 19 4
Christopher Chen, S. Eastwood, T. Hope, B. Mcdonald, P. Francis, M. Esiri (2000)
Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer’s disease prospectively assessed for behavioural changesNeuropathology and Applied Neurobiology, 26
R. Wilson, S. Arnold, J. Schneider, Yuxiao Tang, D. Bennett (2006)
The relationship between cerebral Alzheimer’s disease pathology and odour identification in old ageJournal of Neurology, Neurosurgery & Psychiatry, 78
W. Hoogendijk, I. Sommer, C. Pool, W. Kamphorst, M. Hofman, P. Eikelenboom, D. Swaab (1999)
Lack of association between depression and loss of neurons in the locus coeruleus in Alzheimer disease.Archives of general psychiatry, 56 1
R. Wilson, J. Schneider, J. Bienias, S. Arnold, Denis Evans, D. Bennett (2003)
Depressive symptoms, clinical AD, and cortical plaques and tangles in older personsNeurology, 61
M. Hendricksen, Alan Thomas, I. Ferrier, P. Ince, J. O'Brien (2004)
Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression.The American journal of psychiatry, 161 6
L. Radloff (1977)
The CES-D ScaleApplied Psychological Measurement, 1
G McKhann, D Drachman, M Folstein, R Katzman, D Price, EM Stadlan (1984)
Clinical diagnosis of Alzheimer?s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer?s Disease., 34
C. Tsopelas, R. Stewart, G. Savva, C. Brayne, P. Ince, Alan Thomas, F. Matthews (2011)
Neuropathological correlates of late-life depression in older peopleBritish Journal of Psychiatry, 198
A. Buchman, S. Nag, J. Shulman, A. Lim, V. Vanderhorst, S. Leurgans, J. Schneider, David Bennett (2012)
Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's diseaseMovement Disorders, 27
V. Chan‐Palay, E. Asan, I. t, Sdat Pulmon, '. embolism, Embolism, O. It, Sdat Pneumonia (1989)
Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depressionJournal of Comparative Neurology, 287
S. Lammel, B. Lim, Chen Ran, Kee Huang, Michael Betley, K. Tye, K. Deisseroth, R. Malenka (2012)
Input-specific control of reward and aversion in the ventral tegmental areaNature, 491
K. Seppi, D. Weintraub, M. Coelho, S. Pérez-Lloret, S. Fox, R. Katzenschlager, E. Hametner, W. Poewe, O. Rascol, C. Goetz, C. Sampaio (2011)
The Movement Disorder Society Evidence‐Based Medicine Review Update: Treatments for the non‐motor symptoms of Parkinson's diseaseMovement Disorders, 26
H. Amièva, M. Goff, X. Millet, J. Orgogozo, K. Pérès, P. Barberger‐Gateau, H. Jacqmin-Gadda, J. Dartigues (2008)
Prodromal Alzheimer's disease: Successive emergence of the clinical symptomsAnnals of Neurology, 64
Alan Shafer (2006)
Meta-analysis of the factor structures of four depression questionnaires: Beck, CES-D, Hamilton, and Zung.Journal of clinical psychology, 62 1
K. Tye, J. Mirzabekov, M. Warden, E. Ferenczi, Hsing-Chen Tsai, Joel Finkelstein, Sung-Yon Kim, A. Adhikari, K. Thompson, A. Andalman, Lisa Gunaydin, Ilana Witten, K. Deisseroth (2012)
Dopamine neurons modulate neural encoding and expression of depression-related behaviourNature, 493
R. Wilson, J. Bienias, C. Leon, Denis Evans, D. Bennett (2003)
Negative affect and mortality in older persons.American journal of epidemiology, 158 9
D. Chaudhury, J. Walsh, Allyson Friedman, B. Juarez, Stacy Ku, J. Koo, D. Ferguson, Hsing-Chen Tsai, L. Pomeranz, Daniel Christoffel, Alexander Nectow, Mats Ekstrand, A. Domingos, Michelle Mazie-Robison, E. Mouzon, M. Lobo, R. Neve, J. Friedman, S. Russo, K. Deisseroth, E. Nestler, Ming-Hu Han (2012)
Rapid regulation of depression-related behaviors by control of midbrain dopamine neuronsNature, 493
ImportanceThe neurobiologic basis of late-life depressive symptoms is not well understood. ObjectiveTo test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depressive symptoms. Design, Setting, Participants, and ExposureLongitudinal clinicopathological cohort study at residences of participants in the Chicago, Illinois, metropolitan area. Participants included 124 older persons without dementia in the Rush Memory and Aging Project who had annual evaluations for a mean (SD) of 5.7 (2.8) years, died, and underwent a postmortem neuropathological examination that provided estimates of the densities of Lewy bodies, neurofibrillary tangles, and aminergic neurons in the locus ceruleus, dorsal raphe nucleus, substantia nigra, and ventral tegmental area. Main Outcomes and MeasuresThe number of depressive symptoms (mean [SD], 1.61 [1.48]; range, 0-6; skewness, 0.94) on the Center for Epidemiological Studies Depression Scale averaged across annual evaluations. ResultsBrainstem Lewy bodies were associated with depressive symptoms, and the association was attenuated in those taking antidepressant medication. Brainstem tangles were associated with more depressive symptoms in those without cognitive impairment but with fewer symptoms in those with mild cognitive impairment. Lower density of tyrosine hydroxylase–immunoreactive neurons in the ventral tegmental area was robustly associated with a higher level of depressive symptoms (mean [SE] estimate, −0.014 [0.003]; P < .001; 16.3% increase in adjusted R2). The association was not modified by medication use or cognitive impairment. Neither tyrosine hydroxlyase–immunoreactive neurons in the locus ceruleus nor tryptophan hydroxlyase–immunoreactive neurons in the dorsal raphe nucleus were related to depressive symptoms. Conclusions and RelevanceThe results suggest that the mesolimbic dopamine system, especially the ventral tegmental area, has an important role in late-life depressive symptoms.
JAMA Psychiatry – American Medical Association
Published: Dec 1, 2013
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