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Extrapolation Pitfalls and Methodology Flaws in Curing Anemia via Parental Education and Counseling

Extrapolation Pitfalls and Methodology Flaws in Curing Anemia via Parental Education and Counseling Letters 1 2 quency of melatonin use were recorded in this study, a more disability. Hence, strategies to prevent anemia and mitigate its robust analysis on the possible dose-dependent association adverse effects are of major public importance. To fill this gap in with sleep problems is suggested. knowledge, Shet et al have proposed an effective strategy that Second, there is epidemiologic evidence suggesting the might guide policy makers and practitioners to enhance anemia complex interaction of age and sex in children sleep control at a population level. However, we are concerned about problems. The fact that this study involved children only result extrapolation and data management. aged 11 years renders that extrapolation of the conclusions First, although the cluster randomized design of this trial in this study to the entire school-aged children should be can reduce the likelihood of contamination between interven- done with caution. Additionally, given that sex composition tion and control arms, caution must be taken in the extrapo- differed significantly between the melatonin use and no lation of the findings by Shet et al to rural Indian children be- melatonin use groups, it is thereby of added interest to pro- cause in this trial, a total http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Extrapolation Pitfalls and Methodology Flaws in Curing Anemia via Parental Education and Counseling

Zhou, Bo; Niu, Wenquan
JAMA Pediatrics , Volume 174 (3) – Mar 13, 2020
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References (5)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2019.5051
Publisher site
See Article on Publisher Site

Abstract

Letters 1 2 quency of melatonin use were recorded in this study, a more disability. Hence, strategies to prevent anemia and mitigate its robust analysis on the possible dose-dependent association adverse effects are of major public importance. To fill this gap in with sleep problems is suggested. knowledge, Shet et al have proposed an effective strategy that Second, there is epidemiologic evidence suggesting the might guide policy makers and practitioners to enhance anemia complex interaction of age and sex in children sleep control at a population level. However, we are concerned about problems. The fact that this study involved children only result extrapolation and data management. aged 11 years renders that extrapolation of the conclusions First, although the cluster randomized design of this trial in this study to the entire school-aged children should be can reduce the likelihood of contamination between interven- done with caution. Additionally, given that sex composition tion and control arms, caution must be taken in the extrapo- differed significantly between the melatonin use and no lation of the findings by Shet et al to rural Indian children be- melatonin use groups, it is thereby of added interest to pro- cause in this trial, a total

Journal

JAMA Pediatrics – American Medical Association

Published: Mar 13, 2020

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