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Need for Further Analysis in Cognitive Outcomes of Children Born Preterm

Need for Further Analysis in Cognitive Outcomes of Children Born Preterm Letters et al and Davies et al and maintain that data-reporting im- cognitive impairment should be compared between 2 groups provement is a likely contributor to the trends we detected, as a categorical variable, and then pooled odds ratios can be but other factors may also be present. calculated by meta-analysis. The odds ratios directly indi- We strongly recommend that further methodologic and cated clinical significance. validation research should be conducted to provide evi- Second, when the authors conducted meta-regression dence to interpret and quantitatively adjust observed for associated risk factors, they found BPD was a significant increases in unintentional infant suffocation mortality, as covariate in the model and then concluded BPD was a crucial well as changes in mortality from other injuries or diseases factor for cognitive outcome. However, meta-regression in the United States. Data-reporting improvement may affect analysis is commonly used for investigating heterogeneity mortality reporting greatly, and accurate data allows us to between included studies. The meta-regression showed reasonably and validly interpret health-related trends or BPD explained 65% variance, which indicated the BPD was variations. If needed, data adjustments should be imple- an important source of heterogeneity, but did not indicate it mented prior to release http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Need for Further Analysis in Cognitive Outcomes of Children Born Preterm

Chen, Chengming; Li, Tian
JAMA Pediatrics , Volume 172 (9) – Sep 16, 2018
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References (8)

Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2018.1628
Publisher site
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Abstract

Letters et al and Davies et al and maintain that data-reporting im- cognitive impairment should be compared between 2 groups provement is a likely contributor to the trends we detected, as a categorical variable, and then pooled odds ratios can be but other factors may also be present. calculated by meta-analysis. The odds ratios directly indi- We strongly recommend that further methodologic and cated clinical significance. validation research should be conducted to provide evi- Second, when the authors conducted meta-regression dence to interpret and quantitatively adjust observed for associated risk factors, they found BPD was a significant increases in unintentional infant suffocation mortality, as covariate in the model and then concluded BPD was a crucial well as changes in mortality from other injuries or diseases factor for cognitive outcome. However, meta-regression in the United States. Data-reporting improvement may affect analysis is commonly used for investigating heterogeneity mortality reporting greatly, and accurate data allows us to between included studies. The meta-regression showed reasonably and validly interpret health-related trends or BPD explained 65% variance, which indicated the BPD was variations. If needed, data adjustments should be imple- an important source of heterogeneity, but did not indicate it mented prior to release

Journal

JAMA Pediatrics – American Medical Association

Published: Sep 16, 2018

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