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Letters RESEARCH LETTER life among pregnancies conceived with ART persist into childhood and retain an incremental risk of developing car- Association Between Assisted Reproductive diac remodeling. On the basis of a prospective follow-up of a Technology and Cardiac Alteration at Age 5 Years historic national register–based cohort study, we designed Assisted reproductive technology (ART) has extensively an observational study to investigate cardiac development permitted thousands of childbirths per year for many infer- of children conceived with ART compared with those con- tile couples throughout the world. Although ART is gener- ceived spontaneously at age 5 years. ally considered safe, a growing body of evidence reveals the association of ART with increased risk for poorer perinatal Methods | Based on previous data, we expected a sample size outcomes and congenital malformations. Furthermore, of 100 participants per group to provide 80% power to detect preliminary studies have indicated the presence of cardio- an effect size of 0.35 with a 2-sided α of .05. The ART partici- vascular remodeling in fetuses and infants conceived with pants were recruited by a register-based sample from preg- ART potentially associated with fetal cardiovascular nancies conceived with in vitro fertilization in our center and 3,4 reprogramming.
JAMA Pediatrics – American Medical Association
Published: Jun 1, 2015
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