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Association Between Assisted Reproductive Technology and Cardiac Alteration at Age 5 Years

Association Between Assisted Reproductive Technology and Cardiac Alteration at Age 5 Years Letters RESEARCH LETTER life among pregnancies conceived with ART persist into childhood and retain an incremental risk of developing car- Association Between Assisted Reproductive diac remodeling. On the basis of a prospective follow-up of a Technology and Cardiac Alteration at Age 5 Years historic national register–based cohort study, we designed Assisted reproductive technology (ART) has extensively an observational study to investigate cardiac development permitted thousands of childbirths per year for many infer- of children conceived with ART compared with those con- tile couples throughout the world. Although ART is gener- ceived spontaneously at age 5 years. ally considered safe, a growing body of evidence reveals the association of ART with increased risk for poorer perinatal Methods | Based on previous data, we expected a sample size outcomes and congenital malformations. Furthermore, of 100 participants per group to provide 80% power to detect preliminary studies have indicated the presence of cardio- an effect size of 0.35 with a 2-sided α of .05. The ART partici- vascular remodeling in fetuses and infants conceived with pants were recruited by a register-based sample from preg- ART potentially associated with fetal cardiovascular nancies conceived with in vitro fertilization in our center and 3,4 reprogramming. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Association Between Assisted Reproductive Technology and Cardiac Alteration at Age 5 Years

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References (6)

Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2015.0214
pmid
25915111
Publisher site
See Article on Publisher Site

Abstract

Letters RESEARCH LETTER life among pregnancies conceived with ART persist into childhood and retain an incremental risk of developing car- Association Between Assisted Reproductive diac remodeling. On the basis of a prospective follow-up of a Technology and Cardiac Alteration at Age 5 Years historic national register–based cohort study, we designed Assisted reproductive technology (ART) has extensively an observational study to investigate cardiac development permitted thousands of childbirths per year for many infer- of children conceived with ART compared with those con- tile couples throughout the world. Although ART is gener- ceived spontaneously at age 5 years. ally considered safe, a growing body of evidence reveals the association of ART with increased risk for poorer perinatal Methods | Based on previous data, we expected a sample size outcomes and congenital malformations. Furthermore, of 100 participants per group to provide 80% power to detect preliminary studies have indicated the presence of cardio- an effect size of 0.35 with a 2-sided α of .05. The ART partici- vascular remodeling in fetuses and infants conceived with pants were recruited by a register-based sample from preg- ART potentially associated with fetal cardiovascular nancies conceived with in vitro fertilization in our center and 3,4 reprogramming.

Journal

JAMA PediatricsAmerican Medical Association

Published: Jun 1, 2015

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