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Intratympanic vs Systemic Corticosteroids in First-line Treatment of Idiopathic Sudden Sensorineural Hearing Loss

Intratympanic vs Systemic Corticosteroids in First-line Treatment of Idiopathic Sudden... Key PointsQuestionIs the outcome of first-line treatment of idiopathic sudden sensorineural hearing loss associated with how the corticosteroid is administered? FindingsThis systematic review and meta-analysis of 7 randomized clinical trials did not find evidence that recovery from moderate to severe hearing loss was different in patients for whom corticosteroids were administered intratympanically vs systemically. It also found no evidence that combining the 2 administration routes improved hearing recovery. MeaningFuture research and guidelines should determine which patient groups should be allocated to receive what administration (eg, systemic corticosteroids in elderly patients may be associated with increased risk of adverse effects, and so these patients should be treated intratympanically). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

Intratympanic vs Systemic Corticosteroids in First-line Treatment of Idiopathic Sudden Sensorineural Hearing Loss

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References (38)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/jamaoto.2020.0047
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs the outcome of first-line treatment of idiopathic sudden sensorineural hearing loss associated with how the corticosteroid is administered? FindingsThis systematic review and meta-analysis of 7 randomized clinical trials did not find evidence that recovery from moderate to severe hearing loss was different in patients for whom corticosteroids were administered intratympanically vs systemically. It also found no evidence that combining the 2 administration routes improved hearing recovery. MeaningFuture research and guidelines should determine which patient groups should be allocated to receive what administration (eg, systemic corticosteroids in elderly patients may be associated with increased risk of adverse effects, and so these patients should be treated intratympanically).

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: May 12, 2020

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