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Key PointsQuestionIs the outcome of first-line treatment of idiopathic sudden sensorineural hearing loss associated with how the corticosteroid is administered? FindingsThis systematic review and meta-analysis of 7 randomized clinical trials did not find evidence that recovery from moderate to severe hearing loss was different in patients for whom corticosteroids were administered intratympanically vs systemically. It also found no evidence that combining the 2 administration routes improved hearing recovery. MeaningFuture research and guidelines should determine which patient groups should be allocated to receive what administration (eg, systemic corticosteroids in elderly patients may be associated with increased risk of adverse effects, and so these patients should be treated intratympanically).
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: May 12, 2020
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