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Letters 4. Alonso-Fernández A, Suquia AG, de la Peña M, et al. OSA is a risk factor for In Reply We thank Dr Alonso-Fernández and colleagues for their recurrent VTE. Chest. 2016;150(6):1291-1301. interest in our recently published study titled, “Association 5. Lippi G, Mattiuzzi C, Franchini M. Sleep apnea and venous thromboembolism. Between Hypercoagulability and Severe Obstructive Sleep a systematic review. Thromb Haemost. 2015;114(5):958-963. Apnea.” The comments raised by the readers can be summa- 6. Xie W, Zheng F, Song X. Obstructive sleep apnea and serious adverse rized in that a significant association exists between obstruc- outcomes in patients with cardiovascular or cerebrovascular disease: tive sleep apnea (OSA) and pulmonary embolism (PE), which a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2014;93(29):e336. can be another consequence of hypercoagulability in severe OSA. First, we fully agree with the relationship between OSA and PE. Obstructive sleep apnea has been identified as a signifi- Multidisciplinary Clinical Treatment cant independent risk factor of cardiovascular-related mor- of Head and Neck Cancer tality. Data from numerous studies propose that intermittent To the Editor We commend the authors on their adoption of a hypoxia, sympathetic activation, endothelial dysfunction, multidisciplinary clinic (MDC) for the treatment of head
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: May 15, 2018
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