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J. Bernier, Christian Domenge, M. Ozsahin, K. Matuszewska, J. Lefebvre, R. Greiner, J. Giralt, P. Maingon, F. Rolland, M. Bolla, F. Cognetti, J. Bourhis, A. Kirkpatrick, M. Glabbeke (2004)
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Drafting of the manuscript: Sher, Nedzi, Koshy. Critical revision of the manuscript for important intellectual content: Sher
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Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck.The New England journal of medicine, 350 19
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Key PointsQuestionWhat are the recent patterns of care in the postoperative treatment of patients with oropharyngeal squamous cell carcinoma, and to what extent does intensified locoregional therapy affect survival? FindingsIn this analysis of patient data from the National Cancer Database, high-risk pathologic features, human papillomavirus negativity, and treatment at a nonacademic institution were associated with the use of chemoradiotherapy. Treatment with chemoradiotherapy and boost doses of radiotherapy did not improve overall survival. MeaningThe variation in care deserves further investigation to optimize outcomes in this population; these data support enrollment of the human papillomavirus–positive population into deintensification trials.
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Aug 1, 2016
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