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Patterns of Care and Comparative Effectiveness of Intensified Adjuvant Therapy for Resected Oropharyngeal Squamous Cell Carcinoma in the Human Papillomavirus Era

Patterns of Care and Comparative Effectiveness of Intensified Adjuvant Therapy for Resected... Key PointsQuestionWhat are the recent patterns of care in the postoperative treatment of patients with oropharyngeal squamous cell carcinoma, and to what extent does intensified locoregional therapy affect survival? FindingsIn this analysis of patient data from the National Cancer Database, high-risk pathologic features, human papillomavirus negativity, and treatment at a nonacademic institution were associated with the use of chemoradiotherapy. Treatment with chemoradiotherapy and boost doses of radiotherapy did not improve overall survival. MeaningThe variation in care deserves further investigation to optimize outcomes in this population; these data support enrollment of the human papillomavirus–positive population into deintensification trials. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

Patterns of Care and Comparative Effectiveness of Intensified Adjuvant Therapy for Resected Oropharyngeal Squamous Cell Carcinoma in the Human Papillomavirus Era

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References (17)

Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/jamaoto.2016.1162
pmid
27368076
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat are the recent patterns of care in the postoperative treatment of patients with oropharyngeal squamous cell carcinoma, and to what extent does intensified locoregional therapy affect survival? FindingsIn this analysis of patient data from the National Cancer Database, high-risk pathologic features, human papillomavirus negativity, and treatment at a nonacademic institution were associated with the use of chemoradiotherapy. Treatment with chemoradiotherapy and boost doses of radiotherapy did not improve overall survival. MeaningThe variation in care deserves further investigation to optimize outcomes in this population; these data support enrollment of the human papillomavirus–positive population into deintensification trials.

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Aug 1, 2016

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