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Jennifer Johnson, James Loyd, L. Wheat, J. Netterville (2010)
A case series and review of histoplasmosis infection in the neck.Archives of otolaryngology--head & neck surgery, 136 9
Elizabeth McGraw, J. Kane, M. Kleiman, L. Scherer (2002)
Cervical abscess and mediastinal adenopathy: an unusual presentation of childhood histoplasmosisPediatric Radiology, 32
P. Knight, A. Mulne, L. Vassy (1982)
When is lymph node biopsy indicated in children with enlarged peripheral nodes?Pediatrics, 69 4
C. Kauffman (2007)
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L. Goldani, C. Klock, A. Diehl, A. Monteiro, A. Maia (2000)
Histoplasmosis of the ThyroidJournal of Clinical Microbiology, 38
D. Kadaria, D. Archie, Ibrahim SultanAli, D. Weiman, A. Freire, M. Zaman (2013)
Dual Time Point Positron Emission Tomography/Computed Tomography Scan in Evaluation of Intrathoracic Lesions in an Area Endemic for Histoplasmosis and With High Prevalence of SarcoidosisThe American Journal of the Medical Sciences, 346
T. Fahey (2012)
Impact of Mutational Testing on the Diagnosis and Management of Patients with Cytologically Indeterminate Thyroid Nodules: A Prospective Analysis of 1056 FNA SamplesYearbook of Surgery, 2012
ImportanceBenign granulomatous disease may mimic malignant disease in the evaluation of mediastinal or pulmonary lesions. However, histoplasmosis as a cause of cervical lymphadenopathy is relatively rare. We report the first case of Histoplasma infection mimicking malignant adenopathy discovered during diagnostic thyroid lobectomy. ObservationsA 2.5-cm, calcified, right paratracheal lymph node intimately involving the recurrent laryngeal nerve was discovered during lobectomy for a follicular lesion of undetermined significance with a positive NRAS mutation. Although metastatic thyroid cancer was the most probable diagnosis, results of gross inspection of the bisected thyroid nodule suggested a benign process. Partial removal of the node, sparing the nerve, established the diagnosis of Histoplasma capsulatum infection. Conclusions and RelevanceHistoplasmosis is a rare cause of cervical adenopathy that should be considered in cases in which a discordance arises between the malignant gross appearance of the adenopathy and the benign gross appearance of an associated thyroid nodule.
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Jul 1, 2014
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